Experimental and real-world evidence supporting the computational repurposing of bumetanide for *APOE4*-related Alzheimer’s disease

[约瑟夫]

Starting this as a new thread as it gets buried

*Published: 11 October 2021

https://www.nature.com/articles/s43587-021-00122-7

And the Correction

https://www.nature.com/articles/s43587-021-00144-1

“If you wait until you are ready, it is almost certainly too late.”
~ Seth Godin

[约瑟夫]

Is it time to repurpose geroprotective diabetes medications for prevention of dementia?

For those looking, same review some doctor’s use

[DeStrider]

I think it’s important to read this as well.

Is it time to repurpose geroprotective diabetes medications for prevention of dementia?

It’s not a benign drug is the issue. It is a loop diuretic, I use it for patients with heart failure most commonly. Potassium needs monitoring and often needs supplementing, it can make your kidney function go off badly, you can get hypovolemic, have issues with postural hypotension, alkalosis, oto toxicity, pancreatitis, hepatic encephalopathy, immune reactions include lupus like illness - stevens-Johnson syndrome, increased Uric acid, hyponatremia, elevated blood sugar, photosensitivity …. On and on. As much as many drugs that have a lot of listed side effects have most people have none … this one - and yes it is dose dependent have a very significant rate of having multiple of those actually occur (usually on the electrolyte side of things). So grabbing this off the internet without having a thorough understanding of what would need to be done to safely monitor wouldn’t be the best move. There are other candidates - and also - are we simply adding a drug and no benefit and pote…

[BeatTheOdds]

Hi Joseph. I’m a 4/4 so I’m interested to learn what this means. Those articles are behind a paywall and I’m not schooled in reading scientific papers. I wonder if you could give a brief outline of what it’s all about?

[desertshores]

The problem is the risk-reward ratio is not as good as some of the drugs we discuss here.
It’s very problematic unless you feel you are at a high risk of getting Alzheimer’s.