FWIW, I took Tirzepatide for several weeks with no side effects.
It killed my appetite for months after I stopped taking it.
For me it was the opposite. I had severe side effects especially back pain to the point of walking crooked. I stopped Tirze and started Reta and the pain has started to get better. As far as appetite suppression, I thought they both had about same effect, they basically did what they were supposed to, but with RETA I would get the feeling of being full faster, and often times would leave food on the plate (never happens in real life).
Did you ever try semaglutide? Tirz feels better than sema. I almost jumped from sema to reta but I’m glad I chose tirz. I can always move to reta later, or maybe even add in 1mg of reta a week on top of what I’m already doing.
I’m a believer in tirzepatide. I’m effortlessly ripped and have immaculate blood test results.
If anything I should eat more food. I don’t need to lose weight anymore I can just maintain. It’s a weird feeling in a world full of people desperate to control their desires and lose weight, I have the luxury of the opposite.
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Well, everyone or most using GLP!'s is in the same boat as you, and no I didn’t try Sema. Started with Reta then switched to Tirze (over the concern that Reta is not FDA approved yet) and switched back to Reta, but do 3times @1.3 per week as opposed to once weekly. Very few sides and my back pain (which got worse on Tirze) has almost disappeared on Reta.
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adssx
#450
One more paper showing depression risk with Ozempic: Exploring potential associations between GLP-1RAs and depressive disorders: a pharmacovigilance study based on FAERS and VigiBase data 2025
Only semaglutide demonstrated statistically significant SDRs for depressive disorders in both databases (FAERS: ROR 1.26, 95% confidence interval (CI) 1.15–1.37; IC 0.33, 95% CI 0.20–0.45; VigiBase: ROR 1.38, 95% CI 1.27–1.49; IC 0.46, 95% CI 0.34–0.57), while liraglutide and tirzepatide showed no SDRs. Stratified analyses revealed increased disproportionality in females and healthcare professional reports. WSP analysis showed semaglutide-associated depression followed an early failure pattern, with no significant drug interactions identified with psychotropic medications.
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I think I felt a bit of depression on semaglutide compared to tirzepatide.
I theorized that semaglutide helping control cravings didn’t immediately overcome the emotional satiation giving into those cravings supplied. But if the information you’ve presented is true then perhaps my theory was not correct.
