If you want to learn from the experts on GLP’s and 12.5mg every other week is very high and many of us have started to transition to Retatrutide which is the next level of GLP’s than come over the the group at Jaycampbell.com . You can also see youtube videos of his partner Hunter Williams on youtube on GLP’s .
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PBJ
#22
No thanks, not interested in taking underground experimental drugs.
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cpk
#23
Do you wear a sleep tracker and have you noticed sleep disturbances with tirzepitide?
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Hmm as someone with a couple of years experience prescribing a fair bit of these, I’d not assess 12.5 mg of Tirzepatide every other week high dose (given that 15 mg/week is the maximum).
I have 2 comments/queries:
#1 Taking Tirzepatide which has a 6 day half life every other week will not be near as effective as doing weekly dosing. My suggestion is 5 mg/week would be as effective as 12.5 mg every other week.
#2 Is the reason for this dosing use of a fixed pen (Mounjaro) and cost? If so, my suggestion is to get your prescriber to issue 15 mg pens, split that into 3 x 5 mg doses and do that weekly. You’ll likely have the same efficacy and a smoother serum level, and you’ve just saved 50% off your costs as 1 pen now will give 3 weeks of meds rather than 2.
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KarlT
#25
Who are the “many of us”?
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If you go to Jaycampbell.com we have a community of people including many doctors who use GLP’s. Jay has been using peptides since 2005.
Here’s how you can join the ONLY coaching group on the internet helping both MEN and WOMEN biohack their way to the best shape of your life. I am only sharing this group because i belong to it. I am not selling anything. It’s where you can get answers from other knowledgeable sources. Just sharing ! And every Tuesday there is a a zoom call where you can ask Jay and Hunter any direct questions you want.
https://www.fullyoptimizedhealth.com/start-here
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PBJ
#27
Haha, nice spamming. That website is a clown show.
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It’s not spamming and i’m sorry if you don’t see the value.
Yikes. So much disinformation on that site. Anyone purporting to claim to be in possession of Retatrutide are being disingenuous at best. Retatrutide is in clinical with Eli Lilly and has been for over a year. If your ‘source’ is claiming to have Retatrutide it is a compounded adjacent peptide that’s been wholly untested and is not the same Retatrutide being investigated currently.
I’m all for peptides and bioregulators but you can see for yourself, using the wayback machine that your buddies spam site was setup for sale of the peptide within a few days of the Retatrutide information being shared by Eli Lilly.
What are you actually injecting?
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Davin8r
#30
What do you mean by “compounded adjacent peptide”?
I mean that in the sense that Retatrutide is a research chemical. However, the Retatrutide being run in clinical trials is almost CERTAINLY different than the one being pimped by the shady poster above. Eli Lilly owns the specific formulation and clinical application being trialed.
A compounding pharmacy may have a similar compound they’re actively marketing as Retatrutide. It’s not.
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Davin8r
#32
A molecule is a molecule, but trusting the source in the “Wild West” of peptide research can definitely be a gamble.
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KarlT
#33
I would suspect many compounding pharmacies are making legitimate copies of GLP1 drugs, but if they are making Retatrutide, it would be illegal.
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Congratulations on a great result.
What you have achieved requires a huge amount of drive in addition to the medications listed.
Just one point to consider: I feel that the 40mg testosterone cypionate every second day might be considered to be a regular dose of TRT, but at about 140mg per week it can come with problems and at a lighter dose you will probably get very similar results but remove the risk of these SEs.
I would do blood tests for estrodiol, FSH, LH and also a full blood count to show your MCV (haematocrit).
If the FSH and LH are down to levels of 0.5 or less then it suggests you may be overdoing the testosterone and will get equivalent results at a lower dose.
If the estradiol is raised (>80 pmol/L) then you are converting too much testosterone into Estrogen which will cause weight gain amongst other issues.
If your MCV is greater than 0.49 then the testosterone is stimulating your bone marrow to thicken your blood which can worsen your clotting risk.
In our clinic we have moved away from the regular doses of TRT and have developed a protocol of what we call ‘micro-dosed testosterone replacement’ and found it to be both safe and beneficial.
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Yes, but the work around is occurring at all of the peptide companies with “not for human use” - yet, groups like peptidesciences have Retatrutide. They seemed to have pulled their Tirzepatide - not sure why and have Semaglutide. I have easy accessibility to quality PharmD produced Semaglutide and Tirzepatide from groups like Empower or Olympia.
https://www.peptidesciences.com/retatrutide-6mg
Interestingly groups like Peptide Sciences must be making huge profits as it seems like 60 mg of Tirzepatide probably costs less than $20 for pharma to produce - yet my compounders will give me 34 mg for $300 or 68 mg for $575. It’s still way cheaper than buying from the online “not for human use” outfits.
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Empower is a 503B also and has a lot more stuff than Olympia.
Their 17 mg/mL Tirzepatide 2 mL delivered cold with needles ends up being ~$325 … I use Empower a lot more - I find Olympia has a good deal on a 15 mg vial of Semaglutide but is more expensive on Tirzepatide. Yes on the BUD I don’t get that excited … and just make sure good cleaning of vial and sterile technique on drawing up - but yes - 30 days post first puncture is the rule.
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I’m not too excited with the idea of taking another unhealthy medication (different if you have had a previous heart attack or stroke) to “cancel” out the negative effects of the first. It seems overly optimistic (see my other comment just above)
Jacob_F
#40
The current Mounjaro pens are single dose. They cannot be split up the way Ozempic pens can be.
I think the every other week strategy is pretty good given the shortages. I go 8 to 9 days on Mounjaro doses so that I can stretch it out and have a pen or two on reserve to wait out the shortages.
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Umm I have patients who split the doses, primarily in California as getting compounded stuff sent to CA is challenge.
Magnified glasses on. 1 mL syringe with plunger fully pulled out, facing upwards. Mounjaro autoinjector, unlock, cap off, with Mounjaro autoinjector facing down, very carefully put opening of 1 mL syringe over the needle, and press the button on the autoinjector.
Your 1 mL syringe now contains just over 0.5 mL (50 units on an insulin syringe).
So if you are using the 15 mg/0.5 mL Mounjaro pen, and you need 5 mg, then 0.16-0.17 mL per dose which is 16-17 units on an insulin syringe. So you have your 3 insulin syringes - wait 2-3 minutes for the foam to go down in the 1 mL syringe then carefully advance the plunger until the mounjaro solution is need the tip of the syringe and stepwise, pull a little into the insulin syringe, then advance the plunger, repeat until you have 16-17 units, do likewise with insulin syringe 2 and 3 …
In this fashion - 3 x 5 mg doses from a 15 mg autoinjector. Naturally, just like Mounjaro - keep the insulin syringes in the fridge.
Anyway - have patients who have been doing this for a long time … it’s quick and easy - but need to take care that plunger is pulled down to 1 mL on the 1 mL syringe to the syringe to accept the solution, and that the needle is in the 1 mL syringe from the autoinjector. I’ve had people mess up these steps and end up simply spraying the Mounjaro onto the surface …
Hope that helps … but it is easy once you’ve done it one time.
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