JuanDaw
#123
Read about this in the book “The Oldest Cure”.
The summary is found below:
Here we present a 3-year follow-up report of a case that was originally published in BMJ Case Reports in December 2015.1 Briefly, a 42-year-old woman presented to her primary physician with a palpable mass in her right inguinal region and was subsequently diagnosed with stage IIIa, grade 1 follicular lymphoma (FL). In November 2014, the patient arrived to TrueNorth Health Center (TNHC) and elected to undergo a 21-day medically supervised, water-only fast, after which she refed on an exclusively whole plant food diet free of added salt, oil and sugar (SOS-free), including refined carbohydrates, for 10 days. Over the course of treatment, her enlarged lymph nodes became impalpable. Follow-up CT scans confirmed reduction in size. She did not undergo standard cancer treatment, maintained the SOS-free diet, and was symptom-free at 3-month and 6-month follow-up visits.
1 Like
AnUser
#124
Honestly, to me it looks like most people here have no clue what they’re talking about when it comes to this subject. There is no real expertise, at best we have some doctors using their medical school knowledge, and some people citing one paper at a time. It’s possible to know, it would take a lot of time and effort it looks like to me.
Rapamycin and heart diease - 1 week
Rapamycin and cancer - ??? weeks
4 Likes
If anyone had a clue about cancer, we would have figured out how to stop it by now. Yes, there are isolated causes and types of cancer that have been mostly figured out (everyone knows smoking can cause lung cancer), but those are the exceptions. Even within that example, why do non-smokers still develop lung cancer? Why don’t all smokers develop lung cancer at some point? This whole thread is devolving into people assuming they know more than anyone on earth about how cancer is initiated and progresses. Add in the variable of rapamycin on the completely unknowable problem that is cancer and see the trail of confusion left in this thread.
6 Likes
IMHO, this is the best hope in the fight for cancer. It completely eradicates the cancer, but unfortunately it only works on 5-10% of cancers, but in that 5-10% it is 100% effective.
I hope Dr. B is in that 5-10%
BTW, I am guessing that Mr. Tippens (who was using a checkpoint inhibitor Keytruda) was the lucky guy who matched and got the 100% cure. That’s what checkpoint inhibitors do.
Not dog de-wormers.
Here’s another story of hope. It might have worked for Dr. Seghal. It has a 100% success rate for rectal cancer if the genes match.
If you have cancer, this is where I would start:
1 Like
As someone who is Plant Based for 15 years now and taking daily 20g of ground flex seeds … I can tell you it doesn’t help boldness, at least in my case.
Just an anecdotal input here 
4 Likes
Do you have any concrete ideas or are you just speculating?
I think @rivasp12 has concrete ideas since he’s an experienced medical doctor.
There are scientific papers that show it can prevent cancer. However, like other things that may prevent cancer (antioxidants, NMN, etc…) Once you have cancer, it may make it worse.
May is the operative word here in that we really don’t know if Rapa will make cancer worse. However, since mice almost always die of cancer, and they live longer on Rapa (along with every other model organism) we can make a leap of faith. However, what works on mice doesn’t always work on humans.
It’s a sticky wicket. But here’s some encouraging reading:
And combined with Metformin:
5 Likes
Arhu
#130
Sirolimus/ everolimus are given as treatment options for certain kinds of cancers (kidney, certain breast cancers iirc)
3 Likes
LaraPo
#131
This is the most updated information from Twitter.
3 Likes
gpaiao
#132
T Cells are matured in the thymus (the very reason why they are called T cells).
That’s why thymus rejuvenation will be necessary/important.
2 Likes
Yes, as destrider has pointed out, antioxidants and B vitamins can both prevent and promote.
More specifically, rapamycin and its effects on autophagy.
From the very knowledgeable Agingdoc
At some low doses rapa can be neuro protective , but the opposite at high doses, all dependent on degrees of autophagy.
There was a post on this thread showing the same problem with cancer.
Do I know that rapamycin can promote metastasis? Absolutely not! But I’m now considering the possibility enough to rethink the whole matter and reread the pertinent literature.
It’s certainly supporting my decision to remain at low dosing for the past 6 years.
8 Likes
Well, as a doctor I’ve been an ardent supporter of Blagosklonny and rapamycin over the years,much to the derision faced by other doctors ,but this has caused me to stop and rethink. It’s reason to re-examine the evidence regarding rapamycin and cancer prevention. It would certainly be nice to have some decent human studies.
I’ve openly admitted that we don’t yet know the exact details, so I’m more than willing to change my view once the details emerge. After all, I’ve been on the drug uninterrupted for 6 years.
We need to be moved by whatever evidence is available at the moment. This isn’t a cult of personality. We should always remember Feynman when he essentially said:
Do not fool yourself- and you’re the easiest person for you to fool.
13 Likes
I don’t think of the Soviet Union as a place that made a lot of effort to contain toxins.
3 Likes
I see the added benefits of metformin as both an mTORC1 and AKT inhibitor
1 Like
Yes, but the meta analysis done several years later on over 20 RCT’s showed that the decrease in cancer incidence was primarily the rather benign non melanoma skin cancers, and even that may have been attributable to just substituting for cyclosporine. No effect on other cancer types.
4 Likes
Im pretty sure I read in the past that the lifespan of Russians is lower then many other countries. Might have something to do with their love of Vodka. LOL Did find this: Life expectancy is the average age of death in each country. The global average is 72.8 years. Russia’s life expectancy is 69 against a global average is 72.8 years . Fairly sure its higher in US but since Covid the US age has dropped some. High Obesity in this country isn’t helping extend lives.
2 Likes
Hello everyone, I’m new to the forum and have been lurking for a few months.
I’m not a physician but to me it looks like there are a lot of issues with this meta analysis. It would take me a significant amount of time to go through all the data but here are my biggest concerns:
- Most RCTs used in the meta analysis have extremely short maximum followups which is not good for cancer incidence tracking.
- RCTs that had longer than 2 year maximum followup are a mess (only 2 5). It’s really hard to ascertain anything regarding the efficacy of sirolimus. The longest RCT was 5 years by Lebranchu (2012) participants were taking cyclosporin + mycophenolate mofenil (MMF) for 12 weeks before either opting to continue taking it or to switch to sirolimus + MMF. The problem there is that you are continuing to take an immunosuppresant.
- The best observational study tracks for 14 years (Yanik, 2015). If we dig further into that observational study, there is some solid information that points to cancer incidence reduction. There is a clear 22% lower chance of getting all cancers (more so in lung, kidney and breast) excluding prostate cancer. The most surprising thing in this observational study was that a calcineurin inhibitor (CNI) was used by 72% of participants in the sirolimus-exposed group and 89% by the sirolimus-unexposed group. That is very telling by itself.
- It would be interesting to go over the dosage regimens to determine how much sirolimus participants were taking compared to their immunosuppresants. If whole blood trough levels of sirolimus were available that would also be interesting to go over.
- Participants involved in the RCTs and observational studies are all over (different sizes among groups). Some RCTs also have very small groups.
- Were participants taking sirolimus taking enough to inhibit mTORC2?
- Could combining other immunosuppresant drugs with sirolimus further inhibit mTORC2?
That meta analysis basically reveals nothing due to the large number of unknown variables. I’m still going through all the data. I’d also like to look at more recent and ongoing studies. However, it does seem that sirolimus may have anti-cancer and anti-proliferative properties that helped patients reduce cancer incidence while on immunosupressants.
16 Likes
Thx. for more in depth look. I was just reading the study and had exactly the same questions and it is good to read your view.
I also understand that rapamycin MAY promote cancer. But using the word may in is too broad for a serious discussion on the matter of rapamycin IMO as it is remaining really speculative. It is the same as saying regular exercise may be bad for longevity. @rivasp12 and @DeStrider it would be good not to just speculate but discuss the possible mechanism that could promote or make cancer worse, more aggressive etc. without this we are just staying in the field of fear and feeling of threat maybe even paranoia. I understand that doctors need to act by “first do no harm” principle and caution is part of medical thinking and that using rapamycin on patients for preventative reasons poses ethical questions that can’t be answered unambiguously ATM or probably any moment.
3 Likes
The best way, IMHO, to put this worry to bed is by talking to Dr. Green. He has a large cohort of patients on Rapa and could best gauge any increase in the cancer rate among his patients compared to the general population.
5 Likes
This is my best guess as to why Rapamycin may promote cancer growth.
Rapamycin increases blood sugar levels. Higher blood sugar levels help cancer grow. Large doses of Rapamycin causes very high levels of blood sugar and IGF1. Cancer would love this. ITP results seem to support this with mice on Rapa and glucose control living longest. Remember mice mostly die from cancer.
Solution - Keep blood sugars in check with Acarbose, Canagliflozin and Metformin. Especially when taking Rapamycin. And probably avoid large doses of Rapamycin.
Russia has a lower than normal cancer rate. But this is deceptive as many Russians die of cardio events before they can develop cancer. You will find the countries with the lowest cancer rates also have the lowest life expectancy. But a Russian male should have a life expectancy just over 71. Dr. B drew the short stick and being an early Rapa adopter doesn’t seem to have helped him. 
8 Likes
