#82
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#83

Thanks for this. Personally I do eat a lot of chia seeds which I think have similarities to flax seeds, but I have never seen anything relating to hair loss about them.

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#84

Vlasko, That is an interesting read. One paragraph (not specifically related to the title of this topic) noting oral vs. intraperitoneal administration got my attention:

“A number of studies on rapamycin, testing its effect in aging mice, showed they are prone to develop multiple spontaneous tumors and metastatic-like nodules in the lungs.[31] In these studies rapamycin was fed orally, while in our present study, the rapamycin was administered intraperitoneally (ip). Rapamycin has been shown to extend the life span through delay of cancer in some previous studies,[32] whereas in our present study test mice died earlier via tumor metastasis. This apparent contradiction may be due to the fact that rapamycin administered intraperitoneally may confer a drastically different effect on the metastases than rapamycin administered orally, presumably because rapamycin might be metabolized differently, resulting in different metabolic products of the drug. Interestingly, a recent study [33] showed a quite similar result as seen in our present study, instead of Shikonin-treated tumor cell lysates, they employed sunitinib to offset the metastasis-promotive effect of rapamycin. Importantly, in their study rapamycin was also given via ip injection. Therefore future study is needed to distinguish the possible differential in vivo effect of rapamycin when delivered orally vs. intraperitoneally.”

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#85

This publication states Rapamycin inhibits the growth and metastasis of lung cancer.

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#86

Four years? Below is a blog post with anecdotal evidence of cancer remission.

https://mycancerstory.rocks/the-blog/

Joe Tippens was given three months in Jan 2017.

The good news was that the chemo and radiation had done their job in my Left Lung (which was amazing considering the size of the tumor there). The bad news was that my PET lit up like a Christmas Tree from head to toe. The cancer had spread to my neck, my Right Lung, my stomach, my liver, my bladder, my pancreas and my tail bone. Dozens of tumors.

So he didn’t have to tell me what it meant, I cited the statistics to him as he nodded approval with a grim face. The numbers are simple. <1% survivability and a median/mean life expectancy of 3 months. He confirmed that my numbers were correct.

He is still alive. He took, and is still taking fenbendazole (a dog dewormer). He takes it three days a week.

Bottom of the blog has a Q and A with Joe Tippens and Dr. Deanna Windham on January 18, 2023.

Dr. Windham attended medical school at Oklahoma State University College of Osteopathic Medicine in Tulsa, OK. She did her Internship at Brooklyn Hospital then left New York to do her Residency training at Chino Valley Medical Center in Chino, CA. She has continued her training as a Fellow in Anti-Aging and Regenerative Medicine through the American Academy of Anti-Aging Medicine and the University of Florida.

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#87
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#88

That’s a good point but it seems that in most human studies the decrease in cancer incidence is due primarily to non melanoma skin cancers. This seems to be the predominant effect.

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#89

For what it’s worth, I reached out to a friend who knows a great deal about cellular biology and has read all of Blagosklonny’ s papers. He claims that mTOR is much higher in mice than in humans, and so it takes a much smaller dose for rapamycin to be effective in us.
He still very much believes in low dose cancer prevention, but also that high doses are probably cancer metastasis promoting. So maybe more is definitely not better.

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#91

Is that due to immune suppression?
Interestingly quite recently Bryan Johnson is trying to rejuvenate his thymus, I didn’t understand why that would be so important, but for cancer it seems to be.

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#92

What would be a high dose in his opinion?

Yes, I am starting to agree that a lower dose may be optimal.

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#93

This is nonsense. There are many studies that demonstrate saturated fat is far healthier than vegetable oils.

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#94

It’s certainly difficult to identify the sweet spot. I remember when I first started, both AG and Blagosklonny were on about 5 mg per week. The relative lack of side effects along with the thinking that more might be better, at least in terms of longevity, lead to a shift in dosing. I’ve never increased my dose beyond 5 mg due to the lack of human studies.

I realize that this is an anecdotal case of one, but Blagosklonny has been very influential for most of us, including AG, and he’s written profusely on the value of rapamycin for cancer prevention. For that very person to develop a very aggressive cancer himself, at a relatively young age, is upsetting on many levels.

But there’s much that we don’t know about his situation, and I’m sure he’ll be very forthcoming in the near future.

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#95

Exactly, and Blagosklonny also took high doses of rapamycin recently, more so than what was commonly thought to be safe.

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#96

I will be reducing my weekly dosing to 2 mg + GFJ + EVOO down from 3 mg. Equivalent to about 6-7 mg vs 9-10 mg currently.

Now I wonder if 1 mg + GFJ + EVOO would be better. That would be 3-4 mg equivalent.

This news has shaken me.

Now if Dr. B can survive 5 years, then that would be a positive for Rapamycin.

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#97

I’m not trying to cause trouble here, and I’m going to the field for the rest of the day, but people should keep in mind that he was probably forced to take the jab.

He got a stroke, then a strange cancer. My oldest daughter got a very rare cancer 5 months after her booster. People write about this, but most don’t read it.

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#98

Well luckily we have massive clinical trials that can rule that out.

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#99

I am sorry to hear this and I hope that your daughter will recover quickly.

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#100

I saw that. The first paper you cited talks about “fake info”, immediately assuming that the info was fake. But Joe Tippens was talking about his experience, backed up by PET scans. There is nothing fake there.

The second paper you cited states:

Misleading : The claim is based on the anecdotal evidence of a cancer patient who underwent remission after taking fenbendazole. What’s often not mentioned is the fact that the patient was receiving conventional cancer treatments at the same time, which could also have contributed to the remission.

Tippens did not mislead. He did talk about his chemo. As I quoted above, he said:

The good news was that the chemo and radiation had done their job in my Left Lung (which was amazing considering the size of the tumor there). The bad news was that my PET lit up like a Christmas Tree from head to toe. The cancer had spread to my neck, my Right Lung, my stomach, my liver, my bladder, my pancreas and my tail bone. Dozens of tumors.

The oncologist the article cites is not as dismissive as the Korean gov authors.

Wojciechowski stated that fenbendazole is “a very interesting drug”, but that it’s not recommended to take it “until we have the studies in human beings and we know if it really works or if it’s safe”. He also added that “we do have chemo drugs that are out now that target the microtubules just as fenbendazole seems to do. So if a patient asked me about it I would probably go in that direction”.

Other Korean scientists are not that dismissive. They want to evaluate before concluding. Due process. Listen to both sides before you judge…

Overall, our study suggested a possibility that fenbendazole could be applied for anti-cancer therapy by targeting cell cycle arrest.

These Koreans are even recommending rapamycin with fenbendazole for ovarian cancer:

A certain Tapas Mukhopadhyay commented on Tippens’ blog as follows:

Our earlier work in 2002 on Mebendazole (an anthelmintic drug for pinworm infection approved for use in humans) revealed its potential application as an anti-cancer agent while I was working at the department of Thoracic Surgery in MD Anderson Cancer Center.

A search confirms the claim of .Tapas Mukhopadhyay

Maybe it will lead to nothing. Studies may also prove the effectivity of related drugs - Tapas’ mebendazole. I prefer not to dismiss until studies confirm either way.

The same conclusion in the title of your first article, applies to rapamycin as well -

Lack of clinical evidence for the claim that [dog dewormer fenbendazole] rapamaycin cures cancer.

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#101

The facts are people write about this are discounted, marginalized and ostracized.

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#102

JuanDaw, I agree with you. I read the Joe Tippens blog several times a few years ago and I’m convinced that he did the necessary research and developed his formula of supplements based on his research. And, I’m convinced that he believes his formula works. The best I can tell is that he gets no financial benefit from telling his story which helps reinforce my opinion.

He mentions other people and events in his story which I tried to verify. Everything seemed to be true.

Was it the Fenbendazole or the M D Anderson treatments which included Keytruda? I don’t know, but I don’t dismiss his story just because there is no clinical research. Besides, it does not seem likely that a drug company would fund the bill for research and I can’t see any medical institution taking a stab at it either. From my reading a while back the Fenbendazole story took hold with a vengeance in Korea. So, I can see why it would be a topic of interest there. For example this article:

How cancer patients get fake cancer information: From TV to YouTube, a qualitative study focusing on fenbendazole scandle

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