It’s possible that it would have reached significance. Possible.
Here’s a nice overview , and essentially postulates what I’ve already mentioned, that low dose rapa may have benefits related to CD8+ T cells as well as diminished programmed death cells. This could have cancer implications as we age.
We need some kind of human study looking at 5 mg per week of rapa in a healthy population and cancer rates. Use the general population as a control arm. We need to move from theory to clinical evidence in humans.
Immunologic and dose dependent effects of rapamycin and its evolving role in chemoprevention - ScienceDirect
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I personally like Dr. Luongo’s fast mimicking diet. I’m not a fan of “real” fasting, and wouldn’t be doing it at all without his diet. But to each his own.
Those battling cancer may find useful this recent publication by Paul Merik on the use of repurposed generics to fight cancer. As with Rapamycin, there is little incentive for the medical establishment to promote low-cost effective generic treatments. Particularly when the standard chemo/radiation treatments for cancer are so profitable.
https://covid19criticalcare.com/reviews-and-monographs/cancer-care/
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In my opinion, it’s the 5 days of fasting combined with chemo that gets his results. The small amount of food that he recommends (sells) is just a crutch to complete the 5 day session.
Sure it’s a crutch (ie it can’t be any better for your health than a real 5-day water only fast), but it’s still a useful crutch for many who wouldn’t do a fast otherwise.
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A few years ago, I did the 5 day fast for 3 consecutive months, which he recommends in his book. I didn’t use his food, just had a protein bar each day.
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zazim
#334
I am a fan also. I still have three packages left.
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GregE
#335
Dr. GREEN (rapamycintherapy.com) would agree and told me with my prostate cancer (non aggressive) that R will likely slow the spread but neither cure nor stop it. Because it’s use reduces senescent cell conversion by ~30%, it likely is something of a preventative to delay the onset and premature development of cancer.
Having been a smoker, any thing to delay is a win.
Review Dr. SARAH Hallberg’s interview with Dr. PETER Attie on You Tube about how to manage a cancer diagnosis… so not be as she said, ‘a sitting duck’ one you’ve completed your initial cancer treatment!
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Paul
#336
Here is my N=1 data. Was diagnosed with Prostate cancer 3/2014
Rather than get surgery, I researched and settled on metformin and diet. About 4 years ago I added rapamycin.
MRI’s and testing had shown no progression and a Galleri test last month couldn’t detect any cancer.
Even my PSA is at its lowest levels in 11 years.
I take 10 mg every 10 days. Stopped metformin about a year ago and switched to Jardiance 25 mg
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@Paul question for you on managing the 10 day rapa dosing schedule. How do you do it? I’m having a devil of a time shifting my schedule every week. Workouts, meal schedules, etc. Any secrets? Perhaps you don’t worry about those details.
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Paul
#338
I have a large spreadsheet - record about 20 biometrics every morning
so I record when I take rapamycin and its easy to see 10 day increment
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JuanDaw
#339
Periactin for cancer? N = 1.
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The Beatles were heavy smokers. George Harrison died of lung cancer. Paul & Ringo are doing great.
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Exactly. When he stopped taking rapamycin, the tumors came back quickly
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LaraPo
#342
Do we know for sure that he stopped taking rapamycin?
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UCS
#343
This is as per the statements of his son Ajai Sehgal. See comments # 43 and 53 in this thread above.
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zazim
#345
Yes, that’s definitely what he said. The odds are extraordinarily high that they would’ve come back just the same had he never stop taking rapamycin.
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Jin
#346
Love you reasoning. This is where I’m at too. Until absolutely necessary I’ll stick with my exercise-diet-supplement-rest routine and have as much fun as I can. Rapa would be difficult and costly for me to get at the moment, so it’s still pending.
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