I wasn’t referring to the food that Longo’s organization sells. It’s overpriced but it helps to fund his work. The food also helps with patient compliance. I was referring to Longo’s method.
Longo has had excellent documented results combining an extreme low calorie diet with chemo treatment and it looks like Blagosklonny has gone or will go that route along with his own input.
Do you feel the cancer formed while on Rapamycin?
It depended on the vicissitudes of central planning. They banned plasticizers in water bottles decades before the collapse, but they spread heavy metals and radiation over people without warning.
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AnUser
#250
The table is cropped, you can find the entire table in the study, with the p-value in a column.
That makes me feel a bit better about a moderate dose (~6 mg) not impacting tumor progression. Thanks.
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LaraPo
#257
What is bad luck? Random mutations? Karma? If to go that direction, one should admit that no drug can save anybody from “bad luck”. Is it really so?
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I think “bad luck” for cancer is random mutations that occur in DNA replications. That’s why the older a person is, the higher the probability of developing cancer because random mutations accumulate over time. So every person will develop cancer eventually if they live long enough and don’t die from something else first.
To save us from “bad luck,” we can look to nature for answers. There are animals, such as elephants, whales, naked mole rats, and etc., that have strategies to reduce the incidence of cancer.
We should learn from these animals and see if we can apply their strategies to humans. However, this will require advanced technologies that will likely take a long time to develop.
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It’s interesting that NMR’s have a ton of DNA damage but virtually never get cancer. They have an amazing ability to repair the damage and not get affected by it. They have truly figured out cancer.
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We reporters—or this one, at any rate—often fail to anticipate which stories will grip readers and which will quickly fade into oblivion. Given that, perhaps I shouldn’t have been surprised that a story I saw off to the printing press in the lull between Christmas and New Year’s engendered more comments than any other I’ve written.
The piece, which appeared online with the headline “The simple math that explains why you may (or may not) get cancer” (and in the magazine’s News section with the headline “The bad luck of cancer”), described a paper published in the 2 January issue of Science. As I and many other journalists explained, the study suggested that simple “bad luck”—random mutations accumulating in healthy stem cells—could explain about two-thirds of cancers, exceeding the risk conferred by environmental and genetic factors combined. One message was that some cancers could not be prevented and that detecting them early was key to combating them.
Readers wasted little time in skewering the authors, mathematician Cristian Tomasetti and cancer geneticist Bert Vogelstein of Johns Hopkins University in Baltimore, Maryland. Their statistics were faulty, some argued; they included many rare cancers and left out several common ones. Earlier today, the International Agency for Research on Cancer, the cancer arm of the World Health Organization, put out an unusual press release stating it “strongly disagrees” with the report. The agency said that “nearly half of all cancer cases worldwide can be prevented.” It charged that the authors’ push for early detection “if misinterpreted … could have serious negative consequences from both cancer research and public health perspectives.”
https://www.science.org/content/article/bad-luck-and-cancer-science-reporter-s-reflections-controversial-story
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GregE
#261
No, my PSA had been escalating for the two years prior… and it was that inexorable escalation that I graphed that got the doctors attention. I’m quite fortunate that my adenocarcinoma is not aggressive, not tied to my Testosterone (for osteoporosis) use, and not tied to my bph, and my psa has dropped from 6 to 2. 6 and now to 2.1 very recently… while I’ve escalated my R from 6mg/weekly to about 10mg/week.
No side effects and on reality i started taking it to address severe hand pain that only anti inflammatory meds helped with. Diagnosed about 6 years ago as arthritis. Low dose R, 1-2mg a week generally have me relief about 5 years ago. I cycled on and off R to be sure it was the active variable and it has been of great relief! Now it takes 3-6mg/week. And recently Dr. Alan Green encouraged me to get up to 8-10mg/week due to the prostate cancer. But he had been very realistic in emphasizing that it digress not prevent cancer but only is thought to greatly delay it. For me a distinction without a difference. I know that in all tested species it reduces the senescent cell load by ~30% which is closely tied to many disease processes. I should note i take my R with tadalafil and GFJuice on that one day a week to ‘deepen’ the potential up take of the Sirolimus. I take 500mg metformin ER every am and pm as it’s synergistic on the ampk pathway in offsetting the lipid and bloodsugar issues that R is known to affect. And its notable that R + Metformin achieved the greatest score in the ITP.
Does it all directly translate to what a longditudinal human study will eventually show… is it 90% as effective in mice, c-elgans, Kaberlins big- dog population, small primates? I cannot know but equating R’s chronic/ daily use combined with cyclosporin immunology suppresive dosing and concomitant increase in cancer is a less than careless abuse of deductive logic.
Read the list of ~64 studies Blagasklony listed! And see if there isn’t an overwhelming preponderance of data that shows manipulating mTOR1 downwards is detrimental to growth, even uncontrolled neoplastic cancerous growth.
Should you have any real doubts take the time to fully review rapamycintherapy.com Unless you doubt the biological access to the drivers of cellular aging skip the thesis on evolution. However it might be useful to conceptualize M. BLAGASKLONY’s seminal theory of hypertrophic driven aging. Absolutely brilliant and right before our eyes! We are eternally indebted.
It’s like the discovery of R was like finding early nails at an archeological site and not just deducing a hammer but how the early hominids swung it. Was it not a great observation that the beginning of civilization can be marked to finding the earliest healed broken leg and the cascade of presumptions that it implies?
There are many many discoveries of which we have yet to fathom… this, medically speaking for geroscience is a great leap forward unraveling the nutrition switches connection to aging.
Regrettably, not much mention of limiting A.G.E. foods that offset R in this blog.
Please review Dr. GREEN’s web site, naturally it is not the shallow end of the pool but arming yourself with the best information will lead to a consistently wiser path… having taken R since 2017 and having been a long time patient of Dr. Green (2018, his 38th patient) has provided me an unparalleled access.
I’m a late comer though having cancer already, former smoker, bad diet, a ‘big- dog’ at 6’5" 220lbs with arthritis and an indolent desk worker… and likely not to live as long as even my farmer/ teacher type relatives that pioneered the US northwest.
Just keeping the sharp arthritic thumb pains in abeyance, making my hands much more mobile, suppressing the chronic sterile inflammation without daily steroids (the viox, the rest of it!) has R in the win column for me. It’s unrealistic to expect to see 80s but if I can delay or shorten the chronic debilitating effects of metabolic diseases, then a huge win on the quality of luff score card.
Being an experimental off label application of an FDA approved drug, go in with open eyes, consider the itchiness of doing nothing. At the advent of old age, having tended to cancer ridden parents that suffered strokes and cardiovascular disease anything that can bend that arc of decline outward deserves serious consideration given the horrendous 5% cancer survival progress made in the last 50 years.
As a parting couple of thoughts, find the podcasts of Dr. PETER Attia with 1) a radiologist/math genius on the control of vast moth populations and the implications it has on our failed state of the art methods of cancer treatment 2) Dr. ATTIA’s discussion with Dr. Sarah Halberg and her revised and informed approach to her Stage 4 brain/ lung cancer… it can be found on YouTube broken out from the longer podcast with Dr. Attia and should put into context the moth population control discussion. “DON’T BE A SITTING Duck!”, Sarah. If AFTER reading/hearing BOTH and you are on your early stage cancer treatments and are hopefully just entering remission please reach out to me and I’ll hopefully clarify the lessons Dr. Halberg lived and died teaching.
Gratitude to Dr. Attia for the moth discussion which underlined the problem in cancer treatments.
Thanks all for the venue and your time.
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Great post and I agree with you. Do you take 6 mg a week + GFJ? That would be an 18-21 mg dose equivalent! That’s quite high!
I am currently taking 2 mg + GFJ (6 mg dose equivalent) + EVOO. I also take Metformin the day of dosing (1 g) and the day after (500 mg). Plus I take 100 mg Acarbose at every meal. (See topic Destrider’s Rapa Protocol)
I agree that Rapa + Metformin + Acarbose is a winning combination.
However, I am still uncertain as to the effect on cancer. I do believe that Rapa does not pose a risk of getting cancer, but I am unsure about its effect on metastasis. It is probably different for different cancers. I think it may be helpful with prostate cancer but harmful with lung cancer. I am unsure at this point.
I believe there is a lot of anecdotal data from humans and M. Kaberlein’s dog project that it seems to be helping extend healthspan and lifespan.
For me, it comes down to dosing. What is the correct dose? Is it a U-shaped curve or L- shaped? Hopefully the latter.
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We are so lucky to have this forum with so many interested parties from all walks of life.
I am trained in network and information systems, I hold no medical related degrees. Some days, I’m sorry for that because I’ve worked for a biotech and the work was interesting.
My take on 06/30/2023, with everything that I’ve read is that if I were to be diagnosed with cancer in any way I would get on rapamycin to save my life. The fact that I am 63 and cancer strikes people 70+ very hard, I may just get on it NOW to prolong my life. Better to be safe than sorry.
I am not on rapa now. I was due to start taking it at the beginning of May 2023, but wanted to learn more. I would probably take it 1x/week or 1x every 2 weeks if I started right now. Dosage is yet to be determined, but maybe 10mg or more at a time. I think rapa is beneficial, especially for slowing down cancer. I do not think it has the ability to prevent cancer, but benefit those who may develop it. If I had cancer and beat it into remission, I’d take rapa too.
That’s my take on everything that I’ve read.
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Welcome… 6mg to 10 mg weekly is my plan… healthy to a fault at 65 years. On rapamycin almost 3 years.
I do believe that higher dosing 36mg to 38mg…negates some of the reduction in age and benefits based on my biological tests over the past two years of experimenting with dose. Feel free to private message me for those results.
Jump in… the rapa’s fine!
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GregE
#265
Well said. Read in detail rapamycintherapy.com… Be sure to get an FDA approved maker of generic sirolimus, Zydus, Dr. Reddy etc from a regular pharmacy to insure you get the full bang for your buck. Understand M Blagosklony’s full recommendation.
Consider a consult with Dr. Alan Green who has the oldest medical practice based on Rapamycin. Let him know Greg Edwards patient #38 referred you.
You may wish to start with 3mg/week and build from there AFTER you get basic blood work done…especially IR which is the lead indicator of metabolic syndrome, the root of most diseases of aging. Consider also picking up Metformin 500mg twice a day as it appears to be synergistic with R. And the ITP showed R + Metformin gave the highest longevity results…better than R alone.
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GregE, I enjoy reading your posts.
You have quite the tale to tell. You’ve been there and done it with Rapa and are fighting the Big C. You make me a believer!
All the best to you.
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