I’ve been very surprised by the doses that some people have decided to take on this forum. I guess we all have different appetites for risk. But I understand that without any solid data it’s impossible to make an educated decision. I’m very aware that taking Rapa comes with some inherent risks and many unknowns. Biology is complex and finally balanced. I don’t think it would be a surprise if it were found that Rapamycin prevented AND caused cancer. Very often biological process work optimally in a Goldilocks zone. Some of the recent research on senescent cells is now showing that they have a positive function in wound healing. The more I research the more I’m realizing that the only way to have any control over your biology is by testing frequently and tracking changes over time.
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Of course, I don’t think Rapamycin caused the cancer that was probably done by the smoking. Rapa may have helped it metastasize though. As I am in the heart of cancer alley (ages 41-70) this causes me some concern and caution.
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That’s generally good advice but the Prenuvo MRI is pretty unique and has both a high sensitivity and specificity. I had a few very small things that it determined to be benign. Part of it also has to do with the skill of the radiologist. The one who invented Prenuvo is very impressive. Maybe check it out.
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This is on my list. I’m curious about the process. Did you consult with their doctors or take the results to your own?
Also, mouse models of human diseases are often are often just that, models that only approximate the human disease… So “Alzheimer’s”-type dementia in a mouse is very likely mechanistically different than the actual disease. Therefore what interferes with that disease process in a mouse may be (and sadly usually is) of no effect in humans.
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约瑟夫
#190
“Whole body scan” , yes is a good idea, the issue most people would not have $2,500 or more for this.
And insurance will not pay for a “Preventative MRI scan”
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The human body is a complex system, and we should all maintain a sense of awe and respect for life. Especially when it comes to using rapamycin to extend lifespan, there is currently a lack of substantial evidence from human experiments. Therefore, everyone is taking a significant gamble. There have been cases showing cancer recurrence and metastasis, indicating that rapamycin may not prevent cancer progression and could potentially even accelerate it. It is crucial for us to acknowledge this possible reality and not avoid discussing this particular case, don’t you think? I hope everyone realizes this!
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There are lots of uncertainties. I have things in my protocol which I believe have an anti-cancer effect, but it is not clear how broad the effect is.
In the end there is a certainty of the outcome without taking actions to prevent cellular deterioration. There is no certainty as to what can be achieved, but it is worth trying to improve cellular health. Hence one needs to consider all the evidence.
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scta123
#193
25% of lung cancers do present with brain metastases at diagnosis and 50% spread to brain.
So it is really common for lung cancer to spread to brain and using brain metastases as predictor of rapamycin effectiveness is not really useful.
IMO if rapamycin is really protective agains cancer it must be that slowing new growth and vascularization of new growth and enhancing immune response might the key for its effectiveness in preventing cancer. Autophagy might be another channel. ATM I find evidence that it may help with cancer more compelling than that it would worsen cancer, but I will certainly keep my eyes open for new evidence. I don’t think rapamycin is a miracle cure all drug, a lot needs to be done besides rapamycin…
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Thank you @scta123 . I think we all need to keep our eyes open for anything regarding a link between Rapamycin and cancer.
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约瑟夫
#195
FWIW
This is just my thoughts and what I would do to “treat myself” if I was diagnosed with the same. As there are not many choices, the end point is the same, you expire prematurely.
Do nothing. - not for me
Follow “recommend/standard of care” - NO
Treat myself with my own method/methods.- what I would
Starting with increasing rapamycin in brain area/tissue.
This has been discussed{delivery methods] in other threads, my choice to start rapamycin DMSO solution via intranasal. This simple method will increase rapamycin levels inside the brain area/tissue.
Would also be doing many other self treatment very few would be “standard of care”.
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Well, the deal with lung, similar to pancreatic, is that we didn’t have a decent screening tool until lately. So by the time we recognize these cancers they’ve been growing for a long time to the point, sadly, of metastasizing. That doesn’t mean that they’re quick to metastasize.
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I reviewed the results on my own and searched for any red flags.
I initially found out about this from an article years ago by Peter Attia. He evaluated it, tried it out, and recommended it. I took a look myself and was very impressed. Especially since I’m not in love at present with the more traditional screening tools. Even colonoscopy is coming under some fire of late.
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KFISH
#198
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Again kidney transplant patients are already sick and taking a much more immune-suppressing dose than the people in this forum. IMO the leading cause of the association between increased cancer rates among kidney transplant patients is the prolonged suppression of the immune system.
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LaraPo
#200
Why to increase rapamycin if it’s suspected in contributing to metastases? Could you explain?
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I think these kind of scans makes perfect sense. I had a CAC score a few years ago and while my score was zero I found out that I have a small aortic aneurysm, which my father also had and was recently operated on for. It turns out that it’s genetic, but at now I’m able to track it.
Personally, I believe these type of scans should be the standard of care for anyone over 40. While false positives are a concern, it seems like a weak argument for not getting one. An undiscovered positive that leads to something catastrophic sounds a lot worse to me.
I just wish that it wasn’t so expensive. Hopefully, these scans will find their way into our healthcare system soon.
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KFISH
#202
Then this written by Dr B not sure which way to turn we simply don’t know-
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CTStan
#203
In support of your explanation:
Renal cell carcinoma (RCC), also known as renal cell cancer or renal cell adenocarcinoma , is the most common type of kidney cancer.
Usually, RCC primarily metastasizes to lymph nodes, lungs, liver, and bones, while metastasis to other sites is rare.
Rare metastatic sites of renal cell carcinoma: a case series
Sobering stuff. The most common, lung and prostate, go up, whereas the less commonly seen, kidney and sarcoma go down. The one we care least about, nmsc, also down. Lymphoma, nasty, also up.
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