you understand this is probably chatGPT hallucination
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约瑟夫
#67
The real fact is there is no known dosing of rapamycin for human longevity.
As I have post several times, we are all PFA* dosing for longevity use in humans.
*Plucked From Air
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Mikhail V. Blagosklonny
@Blagosklonny
No inhibition of mTOR2 in humans/. It needs 100-500 nM Rapamycin, not achievable
2:25 PM · May 7, 2023
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blsm
#70
@scta123, that’s super confusing. If he ever clarifies please let me know!
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I will. It is super confusing. Seems he is suggesting daily dosing?
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blsm
#72
Yes, that’s the way I read it too. Was that posted on twitter by chance? If so I might have to reactivate my account. 
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约瑟夫
#74
Do not take this the wrong way.
Why do you not just ask him?
Mikhail V. Blagosklonny
Contact information
推特@Blagosklonny
https://www.roswellpark.org/mikhail-blagosklonny
Mikhail V. Blagosklonny, email: mikhail.blagosklonny@roswellpark.org
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LaraPo
#75
In other word, nobody knows for sure what is the right dose. It’s a matter of trial and error. Pulsed high doses of Rapa could be even harmful per Blagosklonny. What about low 0.5 mg on a daily basis, for a long time? It’s the same as organ transplant patient have been taking for years now. Why not to study such patients to see if there’s a longevity benefit in it. I’ve been on it for 13 years, but there are ppl who take it for 20 years. 20 years could be enough to come to a conclusion if it helps with longevity. Are there such studies? I didn’t see any.
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blsm
#76
I was thinking I’d have to switch to 0.5mg if I were going to take it daily and that might even be too much. I’m currently only doing 2-3mg weekly as it is for a weight of 106 pounds!
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Please remember that as we get older, MTOR is activated more often as our body senses decline and tries to overcome this through MTOR activation. This is why we take Rapamycin, to shutdown MTOR and activate AMPK so that we can recycle and clean up our dysfunctional cells through autophagy. Those of us who are 70 or older and not taking Rapamycin probably have MTOR on constant activation.
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Sorry if the text is not fully understood, my language is not English and this is a translation.
In 2015 ITP carried out tests with intermittent, continuous doses and dosing for three months, even so, all the interventions showed increases in median life span.
There does not seem to be a phenomenon of mtor compensation or mtor resistance.
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LaraPo
#79
Pfizer makes 0.5 mg Rapamune. I already switched to it from 1mg. Want to try how it works without breaks for a month of continuous use. My weight is 110lb.
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blsm
#80
Awesome! Please let me know how it goes. I might try 1mg every other day for now… I have a lot of 1mg on hand to use (with the help of my husband and dog).
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I know what you have stated is true and has been measured; the over-activation of mTOR in aged muscles for example. Do you know, or have a theory as to how the body senses this decline? It seems like it would be very worthwhile to figure out what feedback mechanism is responsible for ramping up mTOR in old age.
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I think you may find most of the information you are looking for here:
It’s a paper published this week by two of the foremost mTOR researchers.
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Reduction of hyperactive mTOR in aging tissues
One reason that mTOR inhibition may have health benefits in older organisms is because mTOR activity may become inappropriately high with age. Higher mTORC1–S6K activity in muscle of older mice, rats and humans is associated with sarcopenia97,98,99,100,101 and, in the brain, is associated with Alzheimer’s disease101,102,103,104,105. Altered mTORC1 signaling with age has also been reported in other tissues of mice, with most studies reporting increased mTORC1 activity with age39,97,106,107,108. The ability of rapamycin to promote longevity is consistent with the idea that mTOR activity is an example of antagonistic pleiotropy, with high mTOR signaling being beneficial for development and reproduction but harmful during a post-reproductive old age109. Under such a model, the benefits of mTOR inhibition may arise less from specific benefits on processes such as translation and more from avoiding negative effects of hyperactive mTOR on processes such as cellular senescence. Indeed, rapamycin has been shown to inhibit the accumulation of senescent cells in mice as well as to suppress the senescence-associated secretory phenotype110.
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Defiantly going to read this entire article in the morning. Thank you for providing it.
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jimo3
#85
You’re right. A lesson learned on ‘hallucinations’… But my point remains as per Blagosklonny’s point in his recent blog post (which wasn’t taken from gptchat).
Thanks for pointing out the hallucination risk!
