#41

How does everyone find their dosage ?

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#42

Hey Lisa… a bit of trial and error.

Being an early adapter at 3.5 years, there was not as much information available on dosing when I started. Consistently 5-6 mg weekly showed up in articles… and as a safe start.

Some noted researchers like Mikhail Blagosklonny said go high as possible without side effects. But… side effects can be silent pathology. I went as high as 38 mg weekly for 7 months and saw a reduction on gains from my lower dose. Not good.

So now 3.5 years in… 6 to 12 mg weekly seems to be my sweet spot in dosing. Will do biological tests next month and see what is happening. Research seems to show women can get by with a little less rapamycin then men and get equal benefits. Good journey.

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#43

Test different levels, do blood testing to track key biomarkers. If you haven’t read these threads, I encourage you to check them out:

  1. What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity?
  2. What blood tests are people taking?, Any rapamycin specific ones?
#44

Bryan Johnson appears to have upped his Rapamycin dosage. His Blueprint protocol (https://protocol.bryanjohnson.com/) is now showing:

Rapamycin (Rx)
wk 1: 13 mg
wk 2: 9 mg
wk 3: 13 mg
wk 4: 9 mg

Most recently he alternated weekly between 6 mg and 13mg…

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#45

That’s somewhat similar to the protocol that I am using. I do the following

wk 1: 4 mg + GFJ (14 mg equiv.)
wk2: 4 mg + GFJ (14 mg equiv.)
wk3: rest

Rinse and repeat. I figure I want to give my body a recovery period where MTOR and activators such as taurine have a chance to do something beneficial.

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#46

Do you take with acarbose?

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#47

I had some side effects like vertigo with 2mg per week, then I dropped to 1mg per week, the vertigo is gone, I feel good. I am especially getting a good response with Rapamune 1mg produced by Pfizer.

#48

Yes…I take acarbose… creatine and taurine daily.
I take my rapamycin at night weekly.

I haven’t had any issues taking them together… :⁰

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