#140

@lurexlu You might try melatonin. @John_Hemming mentioned getting a lot of benefit from putting melatonin on his gums.

#141

Do you have an opinion about what is a safe proportion of transcutol for oral preparations?

#142

Its been a few years since I researched this, but transcutol is a very safe product from what I’ve read. Its regularly used in oral medication formulations. As a toothpaste or flossing paste, I use a small amount - under 5% of the total formulation, and of course most of it I spit out after brushing or flossing.

the estimated oral Permissible Daily Exposure Level of 10 mg/kg/day

Source: A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient - PubMed

related

Info from the manufacturer:

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#143

I’m sorry to say I used it for a couple of weeks and then stopped- not for any specific reason, just no instant gratification…

#144

@Rapadmin Thanks so much for this. i am late to the party and just finding out about Rapa for teeth and gums! I have done quite a bit of reading about it and understand that rapa doesnt go into the bloodstream when used with a body lotion or toothpaste. Can i ask what the benefit would be of also taking a rapa tablet orally along with the toothpaste? Or is there one? I read about how it turns off the mTor so shouldnt be used daily, but instead maybe weekly only. Wanted to know if taking a weekly 1-5 mg. tablet orally would help with the tooth and gum also or would i experience something more I havent learned about yet. Thank you again for posting this! Have been looking for exactly this for awhile now!

#145

The short answer is we don’t know for sure (in humans). In mice it was the oral rapamycin that triggered the interest in seeing if the topical rapamycin would be helpful for dental applications. See this story: New Study: Rapamycin Rejuvenates Oral Health in Aging Mice , and Rapamycin's Impact on Oral Health & its Relationship to Aging (Optispan)

So - in theory it could be an additive benefit to combine the topical/oral toothpaste with the orally taken rapamycin tablet; but we really have no human data yet.

In terms of schedule - we don’t really know and have no good data. In the topical skin cream formulation study they used rapamycin cream on the skin every day, without problems. Rapamycin May Slow Skin Aging (Drexel U. Study)

So, I’ve just used my rapamycin toothpaste as I use my regular toothpaste.

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#146

Thank you so much for the fast reply! May i ask if you have noticed and remineralization on your teeth or, more importantly at least to me, have you experienced any regrowth of your gums? I see this thread started a couple of years back so would be interested to learn any results. Thanks again!

#147

@RapAdmin Absolutely love this and thanks for posting! Question tho…Can you weigh in on whether or not powdered rapa could be used instead of tabets that need to be crushed? It seems like the powder would be alot simpler to use. Thanks!

#148

Yes, absolutely. Either way is fine. I do think powder is easier, but most people already have the tablets on hand.

#149

Wonderful and thanks! Just would have to be able to figure out the correct dose with powder.

#150

You’ll need to get a mg (typically jewelry oriented) scale off Amazon, and then there are examples of the calculations in the DIY rapamycin hand cream thread here: DIY Rapamycin skin cream

#151

Oh thank you! Thats awesome!

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#152

In your ingredients list you posted Zydus Sirolimus. Is Zydus the place you ordered from? I am new to ordering overseas so am trying to learn as much as i can about it. And is Zydus a place you trust and have had good success with? Thanks much!

#153

Zydus is a manufacturer

#154

Thank you for the reply! I know there is a list of resources for ordering Rapa somewhere here on this forum. Would Zydus be there and would you recommend them? Or do you have someone you recommend to order rapa? i have never ordered overseas so not sure what i am doing. Thanks again!

#155

It depends where you live to some extent. Rules on importing molecules vary by country. Zydus wont sell directly you need an online retailer. See the other threads for details.

#156

Thanks! Think I will spend the evening reading through this forum. So glad to have found it! :slight_smile:

#157

See this list of resources regarding sourcing of rapamycin: How to Get Rapamycin, Where to get a Prescription

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#158

So grateful for this post! We found a good source for our rapamycin and are waiting for its arrival so now we are focused on gathering the other necessary ingredients for our toothpaste. Can i ask did you add the transcutol as a way to enhance the rapa absorption? After reading the transcutol safety background article in your post (thanks for that BTW:)
I also read one of your above posts that said-

is it possible to mix a tooth powder with powder rapa? Has anyone tried using it dry?
[/quote]

No - you need something to help the rapamycin get absorbed by the skin & tissue in the mouth - like Transcutol.

sirolimus is an extremely hydrophobic compound and sensitive to temperature, light and pH. Its poor aqueous solubility results in a slow dissolution rate and consequential low oral bioavailability.

May i ask if you have a preferred source to buy it from? Thanks again for all the great information!

#159

Yes, you definitely want the transcutol for increased absorption (IMHO), or some similar agent. I think I used LabAlley.com for getting the transcutol, but its available from many places. All the instructions are very similar to the Skin Cream DIY instructions, we just use toothpaste to replace the skin cream: DIY Rapamycin skin cream

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