#83

Personally I definitely feel a difference, same for husband and brother. Improved cognition & more introspective thoughts. Edit : from PC I mean

#84

I ordered it yesterday and received today. Will use it for a week and maybe write a review. It is really expensive for a simple technology and some nice packaging. I managed to secure some additional discount for testing the device and reporting results with some back and forth with their slowish customer support.

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#85

I can’t wait for Bryan Johnson’s Kernel. Weird that I knew about him before blueprint. Will revolutionize mental health and high positive valence state for sure because of the massive amount of channels for high precision deep brain signal localization EEG. That will zap the default mode network critter, though probably affect memory functions as well. And allow neurofeedback to higher Jhana states etc, though DMN might be helpful for jhana as well.

#86

Cost is perhaps driven by them investing in so much clinical trial stuff?

#87

That + marketing. Otherwise tVNS devices cost less than €50 on Amazon.

I keep following the literature on tVNS and it’s not great. So my Nurosym stays in its box…

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#88

Hope you are right. That some goes into research and not just advertising. I hope to see some results. I used it yesterday for 30 minutes (they recommend 60 minutes a day) and it is really easy to use and intuitively designed.

It is a really expensive device. Without discounts it is 700 EUR (it was 600 EUR before BJ became such a press sensation). I hope it is better than alternatives but probably it is not. I researched some and since some on this forum bough Pulsetto and were not really impressed by the device and app I looked some more and found this two, but were in similar price range. The Vagus.net has currently promotion -200 EUR, but since I got a small research grant I splurged on the Nurosym.

And much cheaper alternative is to use TENS device with ear clip and used at tVNS setting (that is what most studies on vagus nerve stimulator used) pulse width: 250–500 μs, frequency: 10–25 Hz delivered at an individualized constant current (<5 mA), 8mm diameter round metal electrode, conductive paste. This should cost about 50 EUR.

Such alternative would be https://tens7000.com with an ear clip from amazon

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#89

Is he actually still working on that? It seems like he’s completely focused Blueprint now. I thought he gave up on Kernel as I haven’t heard anything new about that in years.

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#90

It seems that Kernel remains quite active in scientific research, with many ongoing studies. Bryan is still heavily involved, as evidenced by his daily visits to the Kernel office implied in his videos. Not all of Bryan’s life revolves around Blueprint. Blueprint seems to be more of his personal project, while he remains active and involved in other aspects of his life and work.

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#91

:grimacing: Have you used it? I haven’t delved deeply into the literature, but a colleague at work is currently conducting a small study on MDP and GAD with tVNS. She seems optimistic and has provided me with some solid evidence. Maybe I should have done more research beforehand. Due diligence!

#92

Yes see the middle part of my post here: Depression and mental health: what do you use? - #16 by adssx

1 Like
#93

What were your goals? Did you use any metrics to evaluate it (like HRV, sleep quality, duration)?

#94

I didn’t test it “properly”. I was anxious and depressed when I tried it so I hoped to see improvements in mood and sleep but didn’t see any. I think I used it daily (or a few times per week?) for 1 to 2 months.

Meditation, CBT-I and low-dose lithium seemed to be more effective for me. (I also feel like dapagliflozin has positive effects on my mood, but it could be placebo…)

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#95

My goals are to achieve deeper and possibly longer sleep. Currently, my average sleep is around 7 hours, but I often need an extra hour in the morning to feel fully awake. Despite this, I still feel tired. I suspect my low blood pressure upon waking (usually around 99/60) may be a contributing factor, as I feel more alert when it rises to 110-115/65. Additionally, having a husband who works as a surgeon and wakes up in the middle of the night doesn’t help.

I’m also aiming to increase my heart rate variability (HRV). It initially improved from 38 (average over a few months) to 45 with a consistent exercise routine. When combined with rapamycin, it increased further to 54. However, following a surgery in January, it has dropped back to around 45. I plan to try Nurosym for 30 days, and if I don’t see any meaningful improvement, I’ll return it.

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#96

I have used my Pulsetto everyday since I received it several months ago. It has an amazing effect on my HRV. I am very happy with it.

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#97

What protocol are you using for the Pulsetto now?

1 Like
#98

I do 12 minutes (the max allowed for a single session) on the SLEEP setting at level 9 (max) right before bed. I simultaneously do deep breathing while I do HRV biofeedback.

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#99

Gyertyán István just answered:

first, I apologize for not responding so long; your first letter actually sank in a stack of unread e-mails. Sorry for that.
Regarding deprenyl, the work is going on with it even after the death of professor Knoll (see 10.1016/j.ejphar.2019.172793;10.3390/ijms22062853;10.1016/j.neuint.2022.105404;10.3390/ijms23158543;10.3390/ijms241713334).
The longevity studies offered by the NIA ITP have already been done with the compound, not only in rodents but other species as well. We also referred them in our paper. A human study would bear a significant value, however, we think, it is currently unfeasible.

The papers he cites are:

Three of them were published by the International Journal of Molecular Sciences, considered predatory/low quality: List of all MDPI predatory journals (*Updated)

Others don’t reproduce the amazing previous life extension claims.

In any case, I don’t understand his point “The longevity studies offered by the NIA ITP have already been done with the compound, not only in rodents but other species as well.”

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How Selegiline ((-)-Deprenyl) Slows Brain Aging
#100

In 1999 / 2000 I started to have mental health problems. I would not have labeled the once in a rare moment “crazy ideas” as hallucinations or dementia, but… by 2003 I had really bad depression. I lost my job in Silicon Valley(Dir of Bioinformatics killed a VP, after being terminated for stealing corporate data) and with it my bride to be and quite a bit of money. Talk about a tailspin! I hit rock bottom pretty hard.

In any case, I muddled on until 2006 where I had full blown psychosis. I’d like to think that the shock to my system of the events in 2002/2003 led me to where I was in life in 2006. Psychiatrists and therapists don’t pull out the diagnostic manual and go, “There you are!” There is a lot that goes into a diagnosis…and after 6 to 12 months of guessing and discussions, we arrived at schizoaffective disorder type 1, depressive.

I take 2.5mg of haldol and sertraline. If I take the full 5mg of haldol I start to have problems with the dose after 3 to 5 days. “Anxieties.” I’ve tried a number of drugs(geodon, respiradol, …) and the best for me is the combination of haldol and sertraline. The other medications are impossible, and overmedicated me to the point of not being able to function at all. I do not like sleeping all day.

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#101

Even though I’ve never been depressed, I take 10 mg of tranylcypromine and 0.5 mg of roflumilast daily.

#102

PDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosis | Translational Psychiatry.