Thiago
#142
Hey @约瑟夫_拉维尔 h. What are your thoughts about this subject after one year? I am still not convinced by any data that flattening is the best. A lot of our physiology has peaks, like blood pressure while exercising, extracellular potassium levels, also while exercising, hormones…"
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@Thiago I just got a free CGM so I may change my mind with new info but my going in position is that cycles are the way of life. A flat blood glucose (and permanently low insulin) all the time would probably be unhealthy and possibly fatal when the lion comes for me.
My problem has long been that my blood glucose is a bit too high based on HbA1c. My fasting blood glucose and insulin are always good, so I’ve been willing to wonder if my blood cell half life is a bit longer than average resulting in a higher hba1c.
I’ll see if I get crazy glucose excursions but I doubt it. I’ll have to eat some stuff that I usually don’t eat just to see what happens.
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The cells at issue in the rodent inulin study are eosinophils, and CRP is not among the cytokines they release. CRP is a good marker for inflammation related to infection and acute inflammation (in the high range) and atherosclerosis and possibly type 2 diabetes (in the low range), but not as a general marker for all forms of inflammation.
According to Colleen Cutcliffe, the CEO of Pendulum, culturing Akkermansia requires extremely rigorous exclusion of oxygen that can’t be achieved with conventional industrial probiotic bioreactors: they had to custom-build their machines from the ground up, starting from pilot systems used in the lab and progressively scaled with much trial and error. Accordingly (she says) most Akk on the market is misbranded. I believe her on this.
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LukeMV
#146
A year after this thread was made, I still haven’t seen any “disturbing information” about combining longevity supplements.
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The liver produces CRP caused by IL-6.
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Yes: not the eosiniophils, as in the study at issue.
So the Eosiniophils produce IL-6 and the liver as a result produces CRP.
I think the original post should disturb anyone who combines different drugs and supplements for longevity:
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But lots of things cause the liver to produce CRP. That’s not useful if you’re querying this specific issue.
That’s why I think it is worth having multiple measurements in order to work out a background baseline.
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This is why I think it is best to have some mechanistic hypothesis for aging. That enables looking at combinations of interventions as to whether they should be cycled separately or used potentially additively at the same time.
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Ulf
#154
Is there a good general marker for all forms of inflammation?
LukeMV
#155
I disagree. He wasn’t a specific at all and didn’t name any supplements or anything. It’s just his opinion as far as I’m concerned. Most supplements and drug combinations have been shown to be synergistic and not antagonistic. The fear mongering isn’t warranted until someone can point out a specific combination that cancels itself out.
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It’s certainly not just his opinion. Brian Kennedy is a widely-published geroscientist who has tested many dozens of compounds over his lifetime and is one of the co-discoverers of the effect of reduced mTOR signaling on lifespan. In context in the video, he’s clearly saying that this is his experience from empirically testing different compounds.
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Here is one common combination that doesn’t work out. It’s better to NOT take these two together. I’ll be cutting my Omega-3 dose in half based on this to 1 g a day down from 2 g.
According to ConsumerLab, it appears that taking fish oil with a statin doesn’t convey any lower risk of CVD. In fact, it provides detriments in a doubling of the risk of Afib. So, you may want to cut back on that fish oil if you’re already taking statins. The 1,800 mg of EPA is equivalent to about 4 g of fish oil which has shown to be correlated to increased Afib in other studies. It seems that the statin provides the benefits and the Omega-3 can’t do anything else for CVD on top of the statin. A 1-2 g dose of Omega-3 daily should be fine though.
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LukeMV
#158
I see all these biohackers measuring their age with all kinds of biological clocks, which I don’t really believe in but they’re consistently seeing positive results by those metrics and many of them are on a whole assortment of supplements and drugs. I’m just not concerned with interactions unless I see something credible enough to convince me. If Brian Kennedy came out and elaborated with specifics, then I’d be open to changing my mind.
Well, no reduction in CVD events by adding EPA in addition to the statins (instead, increased AFIB).
Fair enough. But some of us take EPA/DHA less for CV health, than brain health, dementia prevention.
What would be interesting to see, is ACM for the statin+EPA combo. Because it isn’t super surprising to see no CVD benefit from the combo, considering the statin is what does the heavy lifting wrt. CVD, so the EPA might indeed not bring anything extra. Meanwhile, statins and the brain is a whole other can of worms, and there it might actually be interesting to see if the addition of EPA+/-DHA might move the needle vs just the statin. But again ultimately all cause mortality is where it’s at.
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mccoy
#161
Yes, but unfortunately he’s not specific about the favourable, neutral and unfavourable combinations. I presume those observations have been made during the Ponce De Leon experiments on mice and so it’s proprietary info. Regretfully, not being able to disclose that info is no help at all to the public.
Also, he should be specific about whether his observations apply to animals or humans, or both totally or partially.
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Pat25
#162
Years ago around the time Rejuvant started selling Ca-Akg, I mean to remember Kennedy mentioned in an interview Berberine counteracted some of the benefits of Ca-Akg. But I haven’t been able to find it back.
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