#22

Back to the Subject

A PDF copy of the basics;

Cyclodextrins_An_Overview_of_Fundamentals_Types_an.pdf (943.2 KB)

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#23
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#24

I used to use HP-β-CD at work for oral dosing of compounds, this was over 15 years ago. The premise at the time was that they weren’t orally absorbed and were just a drug delivery vehicle for otherwise poorly soluble compounds. We used to use quite high concentrations of HP-β-CD, I think it was something like 45%.

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#25

I’m part way through my 3rd box, so it’s not that uncomfortable, but it’s a lot of work for me. I usually use it at 8:00 pm and maybe make it through the night half the time. It is uncomfortable, 3 hours isn’t too bad. The vial contains 8 grams and in 30 minutes you absorb 1, they don’t say what happens if you wait longer so maybe nothing more or maybe 6 grams. No information.

I’m kind of sold on it and am trying to give it a fair try. I think it works or I would have quit long ago. Having said that I will probably never know because I did a chelation challenge and discovered I have a problem with lead, so am using an oral chelator (DMSA) and getting rid of it. This seems to really be helping and I had previously tried to see if I had a problem and this is the only way I found out. I do recommend it too. I think heavy metals should be cleared out as they are a huge problem.

I don’t think you get enough with this delivery system to ever have a problem with deafness.

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#26

remchol
remchol1920×2560 266 KB

Ok, just for the heck of it I will give some instructions that will actually work. I used to just twist the top off, sometimes you get a shard of plastic and that is obviously bad, so I would use my nail then to blunt it down. Then I noticed they have essentially put blades on the bottom of the plug. Over an embarrassingly long time I figured out that you should push down on the plug and twist the blades around a little then pull it out. It works perfect that way and it was obviously designed that way. No place does it say to do it that way.

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#28

You get an “A” for effort, for trying this delivery system. Please let us know if you feel you are getting any side effects, and if you see any measurable and positive results!

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#29

FWIW

“The US FDA lists 2-hydroxypropyl-b-cyclodextrin as an approved inert material (excipient), and suited for oral and IV administration”

Have an IV solution made by compounding pharmacy and infusion by IV.

Quoting Dr.James C. Roberts MD FACC FAARFM
A Cardiologist who uses IV cyclodextrin{CD] on himself.

“CD can be administered IV (6 gm. infused over 30 minutes; I receive this during our lunch break), or rectally, 2 gm/dose, taken over 30-90 days. I first learned about CD in 7 /22 (from a patient, as usual). Intrigued, I read every basic science paper I could find (as far back as 1992), and I made contact with the CavadexÔ team, in the US and in Australia (they call you “mate”). The first person treated was myself (I can’t tell that the IV CD is even going in), and then we began rectal CD therapy in a group of patients with prior heart attack and persistent angina on the basis of failed revascularization (their backs were “up against the wall”). These long-standing angina patients reported symptomatic Zbenefit in 2-4 weeks. Thus, 2-3 months of CD makes sense for all of our patients with symptomatic atherosclerotic vascular insufficiency.”

“This positive early experience, mirroring the effect of CD in animal models, has led to my recommendation that all of you with moderate plaque buildup consider a 1–2-month CD program. You won’t feel better, but your plaque volume and plaque inflammation will fall, a preemptive attack on atherosclerosis that developed in the past and which may advance despite out best preventive efforts. Indeed, risk factor control is problematic for many of you (you can’t tolerate lipid-lowering therapy or there are cost constraints). CD is well tolerated, totally safe, and cost is not excessive (in a sense CD is the universal antidote for atherosclerosis). My thinking here is that 1-2 months of CD every year will “make up” for any imperfections in our risk factor control efforts.”

People trying to get involved{and they Do NOT even used the compound] with “cyclodextrin”
To have the FDA stop allowing.

You Lost before you started;

All interested in Cyclodextrin Review

https://heartfixer.com/Cyclodextrin.htm

I have NO interest in the above link.

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#30

It’s illegal for supplement companies to make health claims of supplements to make it seem like they can treat or prevent a disease. Because it causes harm to consumers by using ineffective treatments and delaying proper medical care. Basically health fraud.

Without the FDA people would be smoking menthol cigarettes for asthma.

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#31
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#32

Think!

“Can I use Cyclodextrin to improve the solubility of a compound?”

https://www.researchgate.net/post/Can_I_use_Cyclodextrin_to_improve_the_solubility_of_a_compound

#33

The more I look into this, the more I am interested in an IV solution.

“Cyclodextrin-based delivery systems in parenteral formulations: A critical update review”

https://www.sciencedirect.com/science/article/pii/S093964112200145X

Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and advanced products

https://www.sciencedirect.com/science/article/pii/S0144861723009657

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#34

I want to share my experience with Cavadex, which was recommended to me by Dr. Roberts from Ohio (who I was referred to by my longevity doc in Floriday.) In May, 2023 I experienced some tightness in my chest, and Dr. Roberts gave me a protocol that included Cholrem Cavadex, which was his best suggestion.

At that time, I had a CAC score done, total score was 223 (84%) comprised of Left Main = 0, LAD=141, CRX/LCX=10 RCA=72.3 with the comment that there was a suspected high grade obstruction in the proximal to mid segment of the circumflex.

So at Dr. Roberts suggested I started Cavadex among a few other things which included K-2. He suggested also phospholipids, but I still have that in my fridge. So starting in May 2023, I did 90 doses of Cavadex 8 grams over a period of about 4.5 months. Then in January 2024 I started a course of the 16 gram product and finished 45 doses before getting a new CAC store in May 2024.

My May 2024 results are as follows:
Total score was 212.2 (a decrease of a bit under 5%, however the new score seems to include PDA with RCA which the original did not, so I’m not sure I am comparing apples to apples–it seems that the decrease in total score may be higher than the numbers suggest because the new report includes PDA, where the original did not. Values in May 2024 are Left Main=0, LAD=113, CRX/LCX=7.8, RCA+PDA=91.4.

So, overall, it seems to have reduced my overall calcium score, but how meaningful is this considering the cost of the product and discomfort involved? (Not THAT bad, but it seems like it would take many years to reduce my calcium score by a meaningful amount.

So, there is my n=1 attempt to reduce calcium. I still have about 45 doses of the 16g, so I’ll probably finish it but my hopes are somewhat dashed. Incidentally, I also take a Vitamin C by Natures’ Essentials which combines the Vitamin C with cyclodextrin and then encapsolates that in a liposome, which you may know helps it to pass through the digestive tract. For those of you who are taking Cyclodextrin orally, you are wasting your time, as it is destroyed in the digestion process. FWIW, there are instructions out there and on YouTube that show you how to make a liposomal product in your kitchen with grain alcohol, lecithin and an ultrasonic cleaner device. (I’ve done this, very easy…probably can make a good Cyclodextrin phospholipid for oral use which could be helpful over time. But for cyclodextrin, the best way to take it is IV (which is how Dr. Roberts took it), and good luck with that. Anyway, hope this helps.

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#35

That seems within the margin of error.

Are you treating apoB and have you measured Lp(a)?

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#36

I use it and don’t expect it to reduce the calcium score at all. It should certainly slow the rise of the calcium score. It should reduce inflammation.

If you want to reduce the calcium score, then DMSA is the best way I have found. I’m not sure you need to or should. I’m not a doctor.

Chelation therapy for heart disease

#37

Another false statement from you.

It is not possible to reduce or reverse heart calcification, measured on CAC.
https://x.com/MohammedAlo/status/1737484542053662972

#38

Two things. 1. I had done previous CAC scores and it has been steadily rising for about 5ish years. I believe had I done nothing, it would have increased. And as noted, the second score includes another measurement not included in previous ones, and the total still decreased. It’s something, and with that, it seems to be beyond the margin of error 2. After the score in 2023, I started rosuvastatin and zetia. Lp(a) is high, around 223. I am going to see if my Lipidologist can help me get my insurance to cover PCSK9s next week. If not, I will either pay out of pocket or wait for CETP inhibitors to be approved in a few years.

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#39

It is within the margin of error, it is 10 points from a 220 point score.

If you started at the same time rosuvastatin and zetia that is an obvious confounder in making your CAC score not progress further. The important thing with all of these therapies is that they are proven to reduce your risk of events and stabilize plaque. I would try to reduce Lp(a), too, like you’re doing, that’s high. Good work either way so far.

#40

Is there a way to PM you? I’d like your opinion on something. This isn’t the topic for it, and I don’t see how to PM you or tag you in a new thread.

#41

You can tag me like this @AnUser in a new thread.
Either way, I have enabled PM’s so now it should be possible.

#42

Well one thing to consider is that although your calcium score did not go down significantly, that doesn’t mean that your soft plaque (which really is the issue) wasn’t significantly reduced. The only way to know that is with a CLEERLY test (CT angiogram with AI analysis, https://cleerlyhealth.com).

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