#21

How did you determine those categories though? Did that not reply on some form looking at data and understanding more broadly/in totality?

#22
  1. Yes. 2. Depends on definition of meaningful, but yes. 3. Yes.

Large observational studies, replicated over and over with adjustments for a bunch of confounding factors, cohort designs, etc.

The data for evidence within each category is more sparse.

#23

The hosting is probably under Invision Power Board, I’ve emailed them to ask if they still might have them/not permanently delete boards that have lapsed for 7 days (they manage forums so I hope they’re better than linode in not perma-deleting content that lapses for even one day…)

#25

@AnUser I’ll give it some thought and share some reflections. What are you thinking re exercise protocols?

#27

@AnUser Still owe you some thoughts. I’m the meanwhile you may like this new paper in Nature Aging out today

@AlexKChen @约瑟夫_拉维尔 and @RapAdmin may like to take a look too:

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#28

After nutrition, exercise, sleep, supplements/medications and lifestyle in general are covered, there’s only gene/hormone therapy left.

#29

Gene therapy like follistatin? Why would hormone therapy help with longevity or healthspan?

#30

TRT could help with building and maintaining muscle mass.

#31

Ok, here are some thoughts. High level I would consider

  • Getting amazing sleep, optimal exercise, some degree of CRON (see also new paper out total and my reply to Joe L on that chain), some form of fasting on some schedule and trying to optimize nutrition at the same order of magnitude level of importance as the things in your category 1.

  • I would also add bucket high up in importance, perhaps around #2 on “find your individual risks” & “assess that nothing already is wrong. By this/these categories I means doing an as rich family medical history as possible, understand at least your main genetic risks factors, do a lot of base testing, this means somewhat regulator broad and deep blood works across health categories, as you can afford at some point begin using imaging modalities like brain and whole body MRI, at a certain age (before guidelines) start screening for main cancers in a broad way, etc. This is where your plan becomes customized to you and not just one size fits all.

  • Lastly, I think you are 100% right in wanting to prioritize and create a hiarchy of value of evidence. Where I think you decrease the power of decision making is if you in areas where the higher categories of evidence are not available simplify say - ok, then I will not have an option and will not make any decision. That in itself is making a decision - but one that ignores the evidence that is available. In those areas I often use a risk reward framework. If the risks is low, upside is meaningful, I will make a decision to do something even if evidence is limited. If risks is high and benefit not low, I’ll pick the conservative path until there potentially is very strong evidence of positive expected value, but even then may stay conservative. Where it is trickiest is where reward and risks are high…

  • Actually lastly, and your age and even mine if think we any to try and skate to where the puck will be (and not to where it is now). By this I mean forming some form of sense on what are likely and what massively impactful scenarios of how science, technology and medicine will evolve over the next decades and how do those scenarios play into how to think about todays decisions. If seen you do this when you for instance say that you’ll do statins now while planning to lower them and add PCSK9i and/or BA as those come down in price. That type of thinking on an even bigger scale. What aspects of health will might with a meaningful probability be solved in the coming decades (for me with many decades until I probabilistically become frail, I’m less worried about sarkopenia (I work on keeping an excellent body composition) but I’m more worried about cancers not being curable (and hence don’t over muscle and do Peter Attia level of protein). Similarly, I prioritize more things that are more pro longevity than pro current/medium term health when there is a trade-off when I can choose (not seeking high IGF-1, high testosterone, low SHBG, protein/certain aminos driven higher mTOR, etc) since I think that increases probability of reaching longevity escape velocity or at least the probability of being able to intercept new therapies, technology and knowledge that can add healthy decades to my life.

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#32

In some cases maybe. In many cases it could decrease longevity by putting body in a constant growth mode instead of longevity/protect/ration/recycle mode.

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#33

Yes. It’s a concern. Natural testosterone is pulsatile and varies naturally over time. One of the potential issues with TRT is losing out on this variation. This is one of the reasons I am chasing a boost in my natural T production instead of direct supplementation. And I’m not chasing free T as bioavailable T includes T bound to albumin.

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#34

Ok looks like they might be able to (slowly) figure out how to transfer accounts. Maybe Invisionboard doesn’t seem to delete forums when their payments lapse.

the cached links don’t work anymore today

  • What if I let my license expire?

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Please keep your license active to remain in good standing and protect your community.

#35

Have you spoken with anyone at the CR society to find out why they are having site problems?

#36

yes, prev webmaster died, the treasurer died, they have to figure out how to transfer ownership for account payment

#37

Fuck, they may delete after 1 month (there is no definite time), URGENT CAN SOMEONE FIND Timothy J Calmeyn’S OLD EMAIL? [that’s what they need to trace waht forum it was associated with][

this is the person who died: https://www.legacy.com/obituaries/name/timothy-calmeyn-obituary?pid=203904754

here is the last remaining google cache

#38

Call with a phone, whichever company hosted the forums.

#39

there is no phone number…

#40

Ok, FOR NOW there is a GoDaddy DNS issue for the crsociety.org domain to point at the InvisionForum servers that the forums were hosted [the forums were still in good standing with InvisionForum as of last month, though new admins would still have to be added to the InvisionForum account]… [The thing is, we really need to contact GoDaddy to be able to log into the account of the deceased person and figure out how to get access, or at minimum, to not let it expire]…

#41

ech Email: Select Contact Domain Holder link at https://www.godaddy.com/whois/results.aspx?domain=CRSOCIETY.ORG

Name Server: NS1.FABRICATIONSPECIALTIES.COM

Name Server: NS2.FABRICATIONSPECIALTIES.COM

DNSSEC: unsigned

you missed an important few lines here. The nameservers should be switched to GoDaddy rather than fabricationspecialties

#42

Call here:

1 Like