I wonder myself if a shorter half life would be better for humans. The difficulty really is that there are lots of questions
a) How effectively does it inhibit mTOR
b) What else does it do
Hence that leads to any questions of side effects. Much of what Rapamycin does both positively and negatively comes from inhibiting mTOR.
It may be that it doesnt have any other major mechanisms.
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It is sad that we don’t have answers to these basic questions. My guess which I more and more lean towards is that individualized protocols is most likely the best approach. I have tried to lift this up in some of the talks and interviews I have been giving. Because what is best depends on many factors and by creating some kind of way to find the sweet spot here in an easier way I think is the thing that will give the best effect. In some situations we don’t want to inhibit mTOR like after a surgery. So here it would be really great if we could have some kind of overall metrics which could give guidance. If I have started sketching on one and I’m working on an updated version. Will try to publish it soon. My guess is that if we would also use a similar overall metric in for example mice lifespan studies, but of course adapted to that species, then we would be able to extend lifespan even more than we do today with rapamycin. Because I don’t think for example that it’s optimal to take high doses of rapamycin when the mice are close to dying. It’s like a weak human is lying in a sick bed and that person doesn’t have a long time to live but despite that we continue to give rapamycin to that person. I’m skeptical if that is the right approach. If we are in a weak state then activating powerful catabolic processes is most likely not the best way to go. But this is just my guess and it would be very interesting to test this hypothesis out.
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I think the hard question is working out when you need to ensure mTOR is not inhibited. You are welcome to republish my results published on this forum from a single high dose.
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I’m in!
I am having a devil of a time getting a prescription so I am hoping I can generate some good karma in order to start taking it!!!
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@John_Hemming Can you provide a link to that post?
@Dreamdoc Really big thanks for the support! Have you looked at this page with different physicians around the world who prescribes rapamycin? Rapamycin Prescription, Doctors that Prescribe It
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Yes, I found it after my post.
I am a bit put off by the high costs charged by so many antiaging docs. It feels predatory.
But… I found 2 new sources to share.
Agelessrx.com is offering a simple and affordable monthly fee model for sirolimus among others.
And mobilecarehealth.com - a telemedicine company that I initially used for GLP1 meds, is preparing a sirolimus protocol. Their pricing seemed a bit high for the GLP.1s so I will be curious to see what they charge.
If they are doing a compounded version of rapamycin I would avoid it. There have been many problems with bioavailability of the compounded rapamycin efforts.
FYI they also offer generic sirolimus for $85 per month. They do require labs.
AgelessRx offers both the compounded and non-compounded (generic) forms.
Compounded form is more economical. We account for the reduced absorption by increasing the total dose.
I personally take compounded, 15 mg per week. My sirolimus levels are comparable to somebody taking 4 to 6mg of the generic.
I found that the generic 6MG per week was too strong for me caused side effects such as fatigue and canker sores. Probably because I’m taking other things like metformin, and I’m still in my 40s.
Clinically, I don’t have a strong preference on which one patients take. The generic form is more expensive, but is “tried and true”. But I’m confident enough in the compounding version that I take it myself
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Yes - sorry, I wasn’t clear there. I was referring to the other vendor that @Dreamdoc mentioned: MobileHealthcare.
Interesting paper on mTOR inhibitors as tested in c.elegans:
Characterization of Effects of mTOR Inhibitors on Aging in Caenorhabditis elegans
Pharmacological inhibition of the mechanistic target of rapamycin (mTOR) signaling pathway with rapamycin can extend lifespan in several organisms. Although this includes the nematode Caenorhabditis elegans , effects in this species are relatively weak and sometimes difficult to reproduce. Here we test effects of drug dosage and timing of delivery to establish the upper limits of its capacity to extend life, and investigate drug effects on age-related pathology and causes of mortality. Liposome-mediated rapamycin treatment throughout adulthood showed a dose-dependent effect, causing a maximal 21.9% increase in mean lifespan, but shortening of lifespan at the highest dose, suggesting drug toxicity. Rapamycin treatment of larvae delayed development, weakly reduced fertility and modestly extended lifespan. By contrast, treatment initiated later in life robustly increased lifespan, even from Day 16 (or ~70 years in human terms). The rapalog temsirolimus extended lifespan similarly to rapamycin, but effects of everolimus were weaker. As in mouse, rapamycin had mixed effects on age-related pathologies, inhibiting one (uterine tumor growth) but not several others, suggesting a segmental antigeroid effect. These findings should usefully inform future experimental studies with rapamycin and rapalogs in C. elegans .
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Karel1
#22
https://spotify.localizer.co/uploads/default/original/3X/2/6/26245078ffb07fd4dc54bcbe1364148c0eacfa86.png
@Krister_Kauppi can you explain why sirolimus shows a negative effect on both healthspan and lifespan in this table. My guess dose way too high???
Thanks
Started with Mobile today - after the lab work was done they sent along the scrip and I was able to order Rapacan from the Amazon pharmacy.
I start today. 
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Karel1
#24
Crowdfunding seems great if it is to test substances that are well known and not patentable.
The product/diet etc. should be affordable for at least 80% of the population.
This seems to be relatively news substances based on chemical modifications of known substances which will result in high cost patented drugs and extreme profits for the discoverers.
Why not issue shares and let everyone who invests benefit instead of just the persons that run a farm of C. Elegans worms on a disc. Some persons in this forum can easily spend 25 or 100K without even notice it… I want longer healthspan and lifespan for the masses!
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@Karel1 I have been in contact with different labs around that in some labs they see good benefits of rapamycin and in other ones none. The latest person I talked to this week was with the researcher David Gem and they have had challenges with getting rapamycin to work in worms. Also the ITP for worms CIPT had this issue. The company Epiterna and also other labs. In this clip Mitchell Lee, the CEO of Ora Biomedical, talks about why Rapamycin and other rapalogs are not working as expected. The problem is due to problems with crystallization on higher doses but I think there might be some way to get rapamycin to work. This is why I’m trying to figure out some way for it and talk to different labs.
It’s good that you lift up the investment opportunities and I have started to think more and more around this. One big problem with making this project an investment project is that there would not be any good incentives to make this data public. I feel it’s very important that we provide this basic data to the public. It can not be hidden. But one potential way that I may add as a bonus to this project is that depending on the amount people sponsor the bigger pre-investing amount they will have around these compounds when Rapamycin Longevity Lab starts to develop cocktails around these. For example, let’s say you sponsor 1000$ then you will be able to pre-invest $1000 before everyone else on each new cocktail that the Rapamycin Longevity Lab develops based on these compounds. What do you think about that?
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amuser
#26
The below leads one to believe all 600 are funded by 50K, when in fact it covers only a bit over half the cost.
Suggest updating that 601 to 300.
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Beth
#28
FYI, the link shows the target $ has been met and no more donations are accepted. I guess this is great news!
