Dr. Brad weighs in on longevity benefits of caffeine and coffee.

U-shaped curve for coffee intake

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LOTS OF Trigonelline - Wikipedia (cf mike lustgarten)

Only just come across. I was using glycine in my coffee but what a brilliant idea :bulb: about hydrolyzed collagen peptides instead of milk/cream.

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Yes, Chris’ super coffee :coffee: has been an inspiration. I currently use collagen, trehalose and cocoa powder in my coffee. Will slowly expand the formulation as I get time and enthusiasm…

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Trehalose:

Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans

https://www.pnas.org/doi/10.1073/pnas.1714178115

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Yes, and Fighting Alzheimer’s with Increased Autophagy via Rapamycin + Trehalose

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For convenience and to save expense, don’t bother with glycine capsules and opening them up. Just buy pure glycine powder and add a level teaspoon (about 4-5 g).

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I am a long term coffee drinker 2 cups a day for decades. I put my Taurine, Collagen, AKG and Glycine in it. Easiest way to take these supplements.

Now muscle protection and prevention of sarcopenia.

Molecule in Coffee… Trigonelline helps aging muscles link:

Nice.

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A little weekend rant:
Why has nature gifted me with a taste for things that are not good for me?
Why do I like candy, cake, ice cream, pie, etc.? Is it just the sugar?
Now, I really don’t eat much of these things, but I would love to do so.

I really appreciate that Dr. Fraser is a forum member and provides many health insights.

I visited Dr. Fraser’s website today and read his blog on coffee.
Now I have learned once again what my taste buds prefer is not as good for me.
Of course, I like the coffee that has the least benefits, Arabica dark roasts, while the lighter roasted Robusta coffee has the most benefits.

“Moreover, it has been demonstrated that caffeoylquinic acid
derivatives also exert neuroprotective effects (Hur et al., 2001;
Soh et al., 2003). In detail, it is reported that 3,5-diCQA exhibited
neuroprotective properties against neuronal cell death; this can
be useful for brain protection, as well as in the treatment of
neurodegenerative diseases such as Alzheimer’s disease,
Parkinson’s disease and ischemia (Kim et al., 2005)”

“The contents of caffeine did not vary, but trigonelline decreased with burning up intensity. Chlorogenic acids also decreased with increasing roasting time. The 5-O-caffeoylquinic acid prevailed in Arabica and Robusta beverages, but the isomers of dicaffeoylquinic and feruolilquínic acids remained higher in Robusta”

https://sci-hub.se/10.3109/09637486.2011.588594

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Yeah - I recently realized the “good stuff” is found in greater quantities in the lesser roasts. So I am mixing my dark roast beans with medium roast beans before grinding. I’ll see how low I can go roast wise.

And definitely agree with your shout-out to @DrFraser The insights and rationales he gives when treating his patients are invaluable. I hope he is celebrating the holiday with loved ones and Dimmies!

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I understand the lighter roasts have more caffeine too. That’s enough reason for me.

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@desertshores @RapAdmin
Thank you so much!
I do my best to positively contribute. I’m really grateful to RapAdmin for making this possible.
I’ve learned a lot more than I’ve contributed. It is an amazing group of people on this board, and has led me to investigate things I would not have otherwise.
Learning from patients is among the most valuable lessons - and the group here is like a group of super smart patients who poke and prod at everything - and challenge everything.
Again - a great group, and just a huge benefit to me! Maybe a year from now I’ll be at a level where I can contribute more than I learn.

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Respect brother… I thought you were slightly joking on glycine’s comparability to sugar, but damn if it doesn’t taste good/close to the same! And healthy. I’m someone who needed decent amounts of sugar with my coffee, but this is much better

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Switching from coffee to green tea will reduce this key factor by up to 87%.

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I am one of the unfortunate few who can’t drink coffee. A small cup will spike my BP by 20-30 points.

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Left alone I would go to town on coffee. 450-500 mg worth of coffee caffeine in the morning. With the U-shape figure on some of the graphs I guess (?) its better to hit around 200 mg? I’ve been cutting back.though not sure of the facts

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The future of Coffee and the Cafe?

https://www.cafexapp.com/locations

Source: x.com

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I love robots, but will miss the casual (hopefully) caring interaction with another human being. And paper or plastic cups? Suboptimal.

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image

Drink more coffee. :slight_smile:

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Research on the topic is, generally, pro-coffee. People who drink coffee in moderation may reap longevity benefits like reduced risk of type 2 diabetes, dementia, and all-cause mortality, according to Johns Hopkins. And a 2018 study that followed 500,000 participants’ daily coffee habits found that drinking a few cups of decaf or caffeinated coffee each day greatly reduced the risk of death.

Hone Health shares the exact brews that longevity experts opt for.

Peter Attia: French Press Coffee

Top longevity doctor and Outlive author Peter Attia, M.D., has changed his mind on several of his protocols like intermittent fasting and heat therapy. But there’s one thing he won’t budge on: his daily French press coffee.

Research suggests that compounds like kahweol and cafestol exist only in unfiltered varieties of coffee, like French press coffee and espresso. These compounds may have neuroprotective benefits against conditions like dementia and Parkinson’s.

“Animal studies comparing coffee to caffeine indicate that caffeine in isolation cannot replicate all of the neurological benefits of the whole beverage,” Attia writes in a blog. “Many of these compounds demonstrate anti-inflammatory, antioxidant, antifibrotic, and antimicrobial properties, each of which may contribute to enhancing neurocognitive function.”

David Sinclair: Sugar-Free Coffee

While biologist and Lifespan podcast host David Sinclair, Ph.D., is a big fan of matcha green tea, he still opts for a daily morning sugar-free black coffee to boost his energy.

Sinclair eschews sweeteners, but adds a splash of milk to his brew. Some research suggests this may increase the anti-inflammatory properties in coffee because the amino acids in milk improve the bioavailability of coffee’s polyphenols.

Mark Hyman: Dalgona Coffee

Got a major sweet tooth? Unlike Sinclair, longevity doctor Mark Hyman, M.D., doesn’t skimp on the sugar. Instead, he enjoys his own healthier rendition of frothy, Dalgona coffee (a milk-based beverage topped with coffee foam) every morning.

He uses Four Sigmatic’s Instant Coffee with Lion’s Mane, a mushroom which a study in the Biomedical Journal of Scientific & Technical Research suggests may support cognitive function and mental clarity.

“I love that the combination of coffee and lion’s mane gives me energy that is much longer-lasting, along with a better sense of focus and calm,” Hyman writes in a blog. “Instead of that jittery feeling and without the late-morning caffeine crash.”

Hyman’s Dalgona Coffee Recipe:

  • 2 packets Four Sigmatic Instant Coffee with Lion’s Mane
  • 1 tablespoon monk fruit sweetener
  • 1 tablespoon hot or cold water
  • 6 to 8 ounces non-dairy milk

Use a mixer to whip together coffee, sweetener, and water until frothy. Pour milk into a glass, and dollop the froth on top. Mix and enjoy.

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