https://sinclair.hms.harvard.edu/people/thomas-dixon-mcdougall
More generally, shared across 2c and 7c treatments was an upregulation in the phosphorylation of mitochondrial proteins (Figure 5A). In addition, for 2c-treated fibroblasts, proteins involved in lipolysis and constructing muscle were also increasingly phosphorylated. Although 7c treatment reduced splicing damage (Figure 2E), we observed no statistically significant changes in the phosphorylation of proteins required for mRNA splicing. Overall, we determined that 2c and 7c treatment share a common mechanism in upregulating OXPHOS activity by phosphorylating mitochondrial proteins, with 7c having a stronger effect relative to 2c. We also observed that 2c treatment activated additional pathways (lipolysis and muscle contraction) compared to 7c.
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