#1564

Unfortunately, it’s mg/dL, that’s all the lab UCLA uses does.

1 Like
#1565

Thank you for your earlier response. Did you ever measure how statins affected your Lp(a) levels? Generally, they tend to increase.

#1566

Alas, I did not. I hadn’t ever measured Lp(a) until a couple of years ago, when I convinced my PCP to do a detailed lipid panel that looks at ApoB etc. At that point I was already on a statin, so I have nothing to compare it to.

1 Like
#1567

See this:

1 Like
#1568

I taken Atorvastatin since 2008 at various doses (10-80mg). Have a strong family history of ASCVD and Lp(a) finally measured in 2022 was 195, 190 in 2023. I get no side effects.

Recent remeasure of Lp(a) was 185 on Ator of 40mg. Still high but on a level.
If only Id been able to test in in 2008 pre-statin :thinking:

2 Likes
#1569

Lp(a) in which unit? mg/dl or nmol/L ?

#1570

nmol/l which seems the standard units in the UK. Im in the ‘moderate’ risk category but our NHS doesn’t do primary prevention yet.

Im hoping that the ACCLAIM trial of Lepodisiran reports soon so Lilly can make it available

1 Like
#1571

Have you tried b cyclodextrin it’s supposed to be more effective than the alpha one.

#1572

Yes, I’ve gone through just over 4 boxes of those. Works best to use it just before bed. Still an unfortunate method of application.

Also unfortunate is the possibility of going deaf. I’m really looking forward to the much better cyclarity which is in trials now in australia and could soon be available. I can wait a couple years yet. Should be no emergency here.

#1573

I’m thinking of making liposomal b cyclodextrin.
What dose will be safer in your opinion.

#1574

Isnt there a risk of hearing loss reported in mouse models with CD?

#1575

The Cavidex I’m using is 8ml/day. I doubt very much that you will absorb it all liposomal. I’m sure these guys thought of it. It’s probably safe, but I’d be surprised if it works as well as Cavidex.

#1576

Question for the hive mind:

If one already has a history of heart disease, is there any reason to continue testing additional markers beyond just ApoB during routine lab work? (triglycerides, LDL, etc)

TY!

#1577

I am concerned about the hearing loss too with high dose was thinking of trying a lower 500 mg dose first. Are you getting Cavidex online. Maybe that is the safer route I’ll try that too if they ship to Canada.

#1578

Comes from Australia

#1579

Thanks I’ll try this first.

#1580

Less aggressive than Dayspring and others, but still lower than current standards in many areas:

Open access paper:

Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal

The normal low-density lipoprotein (LDL) cholesterol range is 50 to 70 mg/dl for native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals (all of whom do not develop atherosclerosis). Randomized trial data suggest atherosclerosis progression and coronary heart disease events are minimized when LDLis lowered to <70 mg/dl. No major safety concerns have surfaced in studies that lowered LDL to this range of 50 to 70 mg/dl. The current guidelines setting the target LDL at 100 to 115 mg/dl may lead to substantial undertreatment in high-risk individuals.

https://www.sciencedirect.com/science/article/pii/S0735109704007168

7 Likes
#1581

That’s a really old paper (2004), so surprising to see it here now, I read it about 9 or 10 years ago when I started to learn about this. Old but good.

2 Likes
#1582

Ah, my bad. I saw it today on Twitter and assumed it was a new paper.

#1583

It’s actually more aggressive than what Dayspring recommends to most people: Cardiovascular Health - #1436 by adssx

1 Like