#1009

I don’t know how you could selectively reduce ApoB without reducing LDL, since LDL contains ApoB. You’d have to find other targets on “bad” lipoproteins that aren’t shared with LDL (but that also have ApoB) and go after them separately.

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#1010

Do you have a link to the full article?

#1011

FYI, if anyone is interested in cholesterol levels of children (TC, LDL, HDL, Triglycerides), here’s an excellent paper.

Children up to 12 years old have a very low blood cholesterol level in general.

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#1012

Maybe it’s something about size / volume of cholesterol per particle….

I know the detailed NMR (or what they are called) cholesterol reports and Boston Heart reports have a lot of focus on that

#1013

I read the values, they should be verified by other databases since could be shifted upwards in that population from India. My son who is 21 has a TC= 115 and an LDL = 61 mg/dL, notwithstanding being overweight. Another overweight friend of him has a TC of 113, same age.

Anyways. the article illustrates well the rising trend of cholesterol with increasing age.
Newborns with 24±11 mg/dL is pretty eloquent, in a timespan when brain development his highly accelerated.

Philosophically, it’s interesting to remark that this is one of the body control systems which appears to break down pretty quickly.

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#1014

Colchicine by itself can cause myopathy in humans (hopefully dose-dependent?), but this appears to be exacerbated by rapamycin and simvastatin.

Came across this today when doing an AI-assisted search for effects of colchicine on adaptations to exercise:

Hopefully the low dose used for CVD event reduction will minimize the risk. I’m not currently taking rapamycin or a statin, but those of you who are might want to tread carefully.

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#1015

That is scary. I’ve been taking one day off of colchicine when I do Rapa but only because of the GFJ. Still have noticed nothing in the way of a side effect except that my tinnitus is nearly gone. I’ll extend it to 3 days off (every two weeks), thanks.

#1016

“serious drug–drug interactions are rare and no more frequent than placebo, including in patients taking statin therapy”

That’s good to see. I imagine if there’s a real-world effect of combining with pulsatile rapamycin (and/or with rapa + statin) we’ll start hearing about it soon, since colchicine will likely become a lot more popular in the coming months.

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#1017

Did this become mitigated when you started colchicine, or something else (or other combination)?

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#1018

I think the colchicine helped. I do a lot of stuff, but this (high pitch screaming) has been a serious problem for me off and on. A couple weeks after starting colchicine it got noticeably better.

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#1019

I could do with some noticeable tinnitus improvement myself. About how much was the improvement? >50%?

#1020

I wish I could give you a definitive answer. Some days it’s worse than others and since the explosion it’s been really bad. Colchicine brought it back to low levels. Also maybe it will delay my stroke. My favorite uncle had a stroke a year or so ago and is still trying to die over in the nursing home. I would prefer a more dignified exit.

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#1021

Explosion?? What did I miss?

#1022

Oh, it was my own fault. I spent a day burning piles of logs, using a jug of diesel with just a touch of gas to start the piles. I was tired and didn’t realize that as the mix went out, oxygen from the air went in. The jug was near empty and I got too close and it actually exploded. Not a whoosh but a boom and it soaked my sweatshirt with traces of diesel such that I was stuck with taking a burning sweatshirt off over my head. Lost half my hair and 2nd degree up my arm and neck.

It wasn’t bad for awhile, then the body figures out what’s going on and starts a kind of revolt from the inside. The medical people know what I’m talking about. Don’t let this happen to you. It happened around thanksgiving last year and still my ears are still ringing.

Before people say what I should have done, I’ll just leave you with the wise words of Mike Tyson who in this case knows what he’s talking about. “Everybody has a great plan until they get hit in the face”

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#1023

Wow. Sorry man. Did your hair come back? Any scarring?

#1024

No, no problem. Nothing permanent but the ringing in my ears and it was there before. Live and learn.

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#1025

1600×1190 232 KB

Heart of the Matter: Higher LDL on Keto Does NOT Mean More Plaque

https://www.jacc.org/doi/10.1016/j.jacadv.2024.101109

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#1026

Thank you. Had been preparing a long post but was hesitating because clearly it will get the cackling jackals all worked up. And it takes hours for them to settle down again. Even hours later you will hear them snorting and cursing over in the corner. Muttering “Dayspring…Dayspring” as they drift off into a fitful sleep.

I have tinnitus, too. But it only sounds like high pitch screaming when my wife is in the room.

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#1027

I shouldn’t be upset about people posting nonsense, it’s a private town square and people can say what they want as long as they follow the rules. Why care if someone holds up a sign?

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#1028

Exactly!

5271ce48ad341

That was at the Occupy LDL Movement Protest in NYC.

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