#86

Since the causal inference (internal validity) is good, the generalizability (external validity) is so as well, it is not called ‘extrapolating’. Do you think the causal inference is bad, or are you just being a skeptic for the sake of being a skeptic? Where do you draw the line? Do you not take any drug that hasn’t been studied in a clone army of yourself? As your personal genetics, gut microbiome, etc, surely plays a factor as well.

Why do you take rapamycin, why do you think you can generalize that result to humans, or yourself? It is even worse since its based on animal studies.

I linked RCT’s in humans, that also is consistent with other RCT’s with other conditions, health status when it comes to the causal inference between LDL and events.

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#87

There are just too many cardiologists that say you need to have a low LDL and ApoB to ignore.

If people want to believe otherwise so be it.

I take rapamycin but refuse to ignore increases in lipid levels and I treat them accordingly

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#88

Everybody is different, I guess. Though anecdotal, the best evidence i can provide is my own experience, 57 never been to a doctor and feel same as when I was in my 20’s. Btw I do splurge on anything i like at times, but eat mainly proteins (steak my preferred) and fat, mostly organic. And no I’m not a medical practitioner. Considering that most you guys have ailments in one form or the other, and I have none (including I never get colds, or flu) then I must be doing things right, don’t you things so?

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#89

A total of 181 RCTs with 220 treatment arms (14,505 participants: 7348 cases and 7157 controls) were included. There was a significant reduction in LDL cholesterol (MD: −8.28 mg/dL, 95% CI: −11.38, −5.18), total cholesterol (TC) (MD: −10.82 mg/dL, 95% CI: −12.98, −8.67), TGs (MD: −5.55 mg/dL, 95% CI: −10.31, −0.79), and apolipoprotein B (Apo-B) (MD: −44.99 mg/L, 95% CI: −62.87, −27.12) after soluble fiber supplementation in the overall analysis. Each 5 g/d increase in soluble fiber supplementation had a significant reduction in TC (MD: −6.11 mg/dL, 95% CI: −7.61, −4.61) and LDL cholesterol (MD: −5.57 mg/dl, 95% CI: −7.44, −3.69). In a large meta-analysis of RCTs, results suggest that soluble fiber supplementation could contribute to the management of dyslipidemia and the reduction of cardiovascular disease risk.

HT Lustgarten

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#90

well if rapa increases bad cholesterol, as some are saying why would anyone do rapa. There has been so many substances that supposedly increased life span in mice and fruit flies etc… but none have been proven to be effective in humans, at least up to now. Rapa i thing is the same, just a fad like resveratrol etc…For me i have gotten best results (anecdotal of course) from the following:
Fasting- three-five days every couple months, dry fasting is best if you can, if not drinking water is ok
VitC and L-lysine- for colds and cardivascular help, have a family history of heart problems, i hav been just fine
Niacin- the flushing time is one of the best supplements out there for many ailments especially joint and muscle pain
Niacinamide- great for skin and hair and to protect against sun exposure
Wild cod liver oil- Good for brain energy and heart
Heavy exercise, but only 15 minutes per day, very good in tricking your brain to signal the right hormones, i.e. helping stay agile and healthy.
_used to do vit d3 but stopped because it was giving muscle cramps, which i read it to mean it is depleted micronutrients in the muscle
that is it for now, and i mainly eat proteins and only eat 1-2 big meals per day, try to stay organic ,ost of time

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#91

Can you provide some bit more color on this?

#92

Maybe this study can give some color on that. It is in no regard a definite proof, but it is opening perspective that short burst of exercise might be better for longevity than MICT…
It also makes sense from evolution perspective, people, hunter gatherers, were moving slowly, hunting or gathering plants. This is like walking, stretching, yoga poses :sweat_smile: and then suddenly you are in danger by some random animal and you need to give your best to escape or you must give your best to run to catch it… :wink:

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#93

Surprising that decrease in apoB is almost 2 standard deviations but LDL is quite weak.
Anyone know any soluble fiber sources/supplements that’s good?

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#94

Psyllium husks? Metamucil? Inulin?

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#95

Crap study, IMO, because the control group was also exercising. So we are probably comparing healthy people to healthy people and the result was not statistically different.
I am still alive and well at 82. My current exercise program consists of weight training followed by a sprint on a rowing machine that gets my heart rate up close to maximum.

“All cause mortality did not differ between the control group and combined MICT and HIIT group”

“This study suggests that combined MICT and HIIT has no effect on all cause mortality compared with recommended physical activity levels. However, we observed a lower all cause mortality trend after HIIT compared with controls and MICT.”

This study had a plethora :smile: of responses and critical analyses by other PhDs and MDs. If you are so inclined here is a reference for the responses.

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#96

Thx. for references. I was in no way saying that I feel this is the study that proofs anything, just wanted to say where this thinking of short intensive exercises being better for longevity might originate. And my evolutionary addition was half joking half serious I guess.

And I agree with you on the muscle building part, having strength and muscle mass in old age is the most important thing. I remember when my friends mother who is 86 had covid, a pretty mild case, but was bedridden for few weeks afterwards since she fell on her first day of covid and sprained her back and needed almost a year of physical therapy to be back in shape.

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#97

My mother, 90, also fell and fractured her pelvic bone in 2 places. Doctors told us that she would never walk again. Amazingly, her rehabilitation lasted only 4 weeks, she completely recovered, can walk now without support and even climb stairs and go shopping… The only thing she gave up was driving. She’s on Rapa though (and many other supplements) and it could have contributed to her recovery.

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#99

That is amazing that your mom recovered so fast at that age. How long has she been doing Rapa?

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#100

The contrary opinion of this cardiologist is worth listening to, even if you do not agree.

Dr. Nadir Ali - ‘Why LDL cholesterol goes up with low carb diet and is it bad for health?’

Dr. Nadir Ali is an interventional cardiologist with over 25 years of experience. He is also the chairman of the Department of Cardiology at Clear Lake Regional Medical Center. Before working as a cardiologist, he served as an assistant professor of medicine for eight years at Baylor College of Medicine in Houston, where he also received his medical training.

Dr. Ali has championed many aspects of the science and practice of a low-carb lifestyle in the local Clear Lake area since 2013. He organises a monthly nutritional seminar in the Searcy Auditorium of the Clear Lake Hospital that receives more than 100 visitors every month from the local community. Dr Ali’s focus is on managing heart disease, obesity, metabolic syndrome and diabetes.

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#101

This is a very complex subject but as i age (and hopefully get wiser, hasn’t happed yet lol) i kind of look to find a purpose (so to speak) to everything and anything. I happened to believe (obviously it’s not scientific) that the creator (whoever that was, God, Darwin/Carl Marx for some, Cow for some, or nature or whoever) made us as the apex of all creatures and as such designed within us the ability to find answers (or cures if you like) to everything and anything. The only problem is the road to getting those answers can be quite long and difficult. Basically, they way we are programed is such that we are born, we grow up, we have babies (because the species has to survive) and then we get old and die. But everything that we have been given is for survival purposes only, and not for pleasure, or comfort. therefore, when you exercise your brain thinks that you are carrying the much-needed food to your tribe therefore your brain activates all signals to all organs to produce all the needed hormones to help you, or when you run very as fast as you can, the brain thinks that a lion is chasing you as such the brain triggers all the organs to produce the best and highest hormones possible to help you survive. But if you just walk or jog, your brain thinks you are doing it for fun, and basically says screw you, you are on your own and you don’t get nowhere near the benefits that you would get from intensive heavy exercises at short intervals.
Also, if you overdo it your brain says you know what this guy is really suffering, therefore let just get his misery over and you most likely will drop dead. I.e. there was a dude doing like 12 miles of daily running and he dropped dead at about 55. So, much better to sprint 250 yards all you can per day than to run 5 miles as an example.
I can go on for ages but i hope you get the just of it.

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#102

“I really don’t care either way”…proceeds to lecture on how wonderful his regime is.

Look; you enjoy good health and that’s great. You may have inherited a good set of genes.
If you look at Supercentenarians (the best examples of successful aging we have), there are vegetarians, there are meat-eaters, there are smokers and non-smokers. There are drinkers and teetotallers. There are active ones and there are slobs. What it really means is that “genes trump lifestyle.”

I, also, enjoyed great health until I was 59. Then suddenly I caught pneumonia (hadn’t had a sniffle for 11 years prior), which precipitated atrial fibrillation. Then I got Jumper’s Knee and Plantar Fasciitis in the same leg. One after the other. Hopefully all fixed now.

If you believe that your lifestyle has given you good health; good for you. But trust me; the wheels can fall off very quickly!

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#103

3 years on Rapa, 2mg week.

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#104

What genes dude, my mom passed away at 59 from a stroke, my dad had severe angina, my grandfather died at 57 and my grandma passed away of a heart attack at 55.
You say:
"If you look at Supercentenarians (the best examples of successful aging we have), there are vegetarians, there are meat-eaters, there are smokers and non-smokers. There are drinkers and teetotallers. There are active ones and there are slobs. What it really means is that “genes trump lifestyle.”
I disagree 100% with your reasoning. The main reason why these people are living this long is because their lifestyle (whatever it is) has actually fooled their internal clock (without them even doing it intentionally) and as such they enjoy long life. The genes play a very small portion the rest is up to you/me/us. And the main think you need is adversity, being very heavy exercise (short period), fasting or swimming in the ocean when temp is 35 degrees Fahrenheit (i do that sometime btw) and this triggers the survival mechanisms’ within ourselves and all the protective solders are mobilized as such all your ills are fixed. This is because your brain thinks that you are doing it for survival reasons and you have much more to live, you are nowhere near the end of your cycle/life therefore it triggers all the good juices within your body to start flowing. I can literally see myself being 110 years old and still driving my own car. To an outsider it sound nuts, or probably you would just ignore it as nonsense that anyone can say it now since who knows what ill happen in the future, but trust me i say it because something inside me is telling me that is totally possible. I’m a total loss at how resistant and strong i am. I used to think that when I’ll be in my late 50’s I’ll just take it easy and travel and semi retire etc, but i have way more energy than when i was 30, it is totally nuts. And. I’m not eve doing very extreme things like some people do. I just try so many things (supplements, food, heavy exercise, fasting etc) and stick with what i see as working for me, and i just can’t believe it myself that a 57 year old person can be in such health. As an example there is a 27 year old dude that works in my place and he is really ripped and bench presses like 300lbs or who the hell knows (stays hours in gym,), so I joke the other day and tell him lets arm wrestle, he goes ok, he didn’t fucking last more than 15 seconds, he kept looking at me weirdly, and feeling my arms and muscles (which are just normal btw, he is a huge mother fucker) and couldn’t believe it . Again, I’m totally lost for words myself, and also find it so weird but i think that the more adversity you introduce in your life style the better, plus if you take the right supplements, that should help also.

#105

But in summary, anything you do and you see it working for you, never overdo it especially never exercise for long hours, 15 minutes of heavy exercise, sprint or whatever you feel is good enough. also, always take a rest, i.e couple days per week don’t take any supplements and don’t exercise at all as an example.

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#106

I totally agree and concur this. Everything good in excess becomes bad. There is this fine balancing that is important in life in every sense.

I had all my grandparents live well into their 90ies and have been watching them. They were active all life, but knew that rest is important too. They were eating well, but not in excess. They all enjoyed life and kept working and had active social life almost until the last days. At the end also accepting ones own mortality makes for a less anxious life. You live more, you are happier and maybe have a chance to live longer.

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