Absolutely, the ER Doctors are aligned on these 2 statements!
Furthermore, I don’t think resveretrol taken orally does anything. I think Dr. Stanfield has a decent review as does Matt Kaeberlein.
It’s not on my list for anything.

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Aiui Resveratrol is an HDAC and cox-1 inhibitor. I don’t like inhibiting cox-1.

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I am a work in progress, lol. I never want to take Medicine but natural stuff? Gimme gimme gimme! I was doing some more reading about rosuvaststin and may just go back on it. Only stopped it about 3 months ago and I was only taking 5mg for precautionary reasons. My ldl cholesterol pre my heart attacks in 2020 and then even last year has always been in the 40s so I’m not sure my switching to reservastol is a factor in the big jump to 123 LDL last week. Sigh. I appreciate all the knowledge and carefully worded advice around here in this group. :slight_smile:

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It’s interesting how people have different perspectives. For example mine happens to be the exact opposite - “I never want to take any ‘natural’ supplement, but medicine, gimme, gimme, gimme”.

“Natural” is a strange concept. Arsenic is “natural”, so is snake venom and any number of plant poisons. And many of the “natural” supplements are extracts of substances in plants or massively concentrated select ingredients that would never occur in nature at those doses - highly “unnatural”.

Apart from marketing, “natural” really means very little - and the little that it does mean, is all very, very, very bad. When I see “natural”, I immediately distrust it - here is why…

“Natural” supplements, means these are some poorly characterized, poorly studied molecules that occur in random amounts in a plant, that you really don’t know what they are doing. A plant extract is often just a collection of thousands of different chemicals which have never been studied. You are taking it on faith that somehow this random collection is going to have a good health effect. Often that is not the case, as thousands of cases of all kinds of negative outcomes and even deaths, liver failure, organ failure, poisonings and overdoses all come from “natural” supplements, which - alert - are not cleared or regulated by the FDA. You are playing russian roulette with your health. “Natural” supplements to me are mystery pills in a bottle.

Here is a fact - the vast majority of these have never been properly studied. At best, there are some small trials, often by the seller or interested parties, often poorly designed studies that form the basis of various health claims - which must then, to keep it legal, have a disclaimer that they are not designed to treat any condition… which somehow gets ignored by the consumer, SMH.

Now contrast that with medications. A medication, before it gets approved by the FDA or any health regulatory agency in the developed world, must undergo extensive trials with multiple stages - phases designed to prove that the medication is SAFE for humans - which a “natural” supplement doesn’t do, or is required to do. Pharma companies spend billions developing a drug. A “natural” supplement can be some guy stuffing god knows what into pill boxes in his garage. Next, it must be determined that there is a positive health outcome - so not an equivalent of a sugar pill or “natural” supplement where you have to take it on faith that it works. Then there are clinical trials with large numbers of subjects which tell us the real world effects of the medication. The medications are all under scrutiny from medical researchers, from doctors in practice and from patients - there are databases where side effects are reported and followed for years. None of this is true for “natural” supplements - all you hear are “testimonials” often paid for, anecdotal tales and then they can make the news when someone tragically dies or is severely injured… just no controls at all. And medications must list in great detail all the possible side effects, even the very rare ones. Not true of “natural” supplements. And when the medication is manufactured, it is manufactured to exacting specifications and under the scrutiny of the appropriate regulatory agency, the FDA. When you get the medication, you are assured that you are getting exactly what is says on the packaging, at the dose specified. Meanwhile, none of this is true for “natural” supplements, and in fact repeated investigations have shown that often the vast majority of what is sold in supplements has either none of the claimed ingredient, a harmful ingredient or an ingredient at some random dose. It’s absolute Wild West, completely unregulated - the regulatory agencies only get involved when people start dying.

Does this mean that all medication is safe? Nope. There’s always a risk. But at least we have a mechanism for control. You have no idea what it is that’s in your “natural” supplement. I like medications because I have a certain amount of assureance that I know what I am getting. And I can carefully read extensive studies of these medications and then make my decision. I have none of these tools with “natural” supplements.

To me, the analogy is between buying alcohol from a well-known and regulated and subject to the law manufacturer in a legal store. That’s medication. It might be good or bad for me, but I know what I am getting. Meanwhile, someone tells me, “nah, I avoid those stores and manufacturers, I prefer that one guy in a dark alley who can hook me up with a homebrew moonshine made somewhere that no regulatory agency has access to, but it’s good, trust me bro”. I have no faith that the hooch from the dodgy guy won’t leave me blind. I know what I’m getting from Seagram or Johnny Walker bought at the supermarket. Both want to make money, but only one is held accountable, and consequently has to maintain standards and safety. Do you see why when I hear “natural” - I flee as fast as legs can carry me, and meanwhile, I will carefuly consider medication from an established provider?

My point is not to say that my approach is better than your approach. It is to simply present a case of why having the opposite approach has its own logic. I’m not trying to convince you of anything, just provide another way of looking at things, the final choice is always up to the individual. YMMV.

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Ah well nevermind. xx

Have you made any changes in your diet or drug regimen in the past month?
Are you taking rapamycin right now? Higher dosing, or more frequent dosing, can raise blood lipid levels.

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Hi! The only change I had made was swapping the 5mg statin for 120mg reservastol.
I have been taking a hair vitamin called Nutrafol for a few months, too.

I took one 1mg sirolumis pill last Friday and have been monitoring my bp daily.

Tonight I started back on the 5mg statin…

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One other thing, I take 240mg diltiazem which I just learned reacts with the sirolimus… it increases the Siro dosage like double…

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Given you’re currently dosing at 1mg, its not a big deal (if the effective dose is 2mg) - but something to be careful about if you move to higher doses of rapamycin / sirolimus.

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Although I have sympathy with your analysis I am concerned about safety. Hence if there is a herbal medicine that has been used in varying doses over centuries I think we would be aware of cases where people had been harmed by it.

Which we do with Ashwaghanda (number of liver problems) and other herbal substances which have some case reports.

Similarly we know with Rapamycin what has happened.

I am not really otherwise bothered about whether something is “natural” or not. On the other hand I don’t want to inhibit cycoloxgenase (1 or 2) and I concentrate on the route towards mRNA transcription via efficient mitochondria. Otherwise I am not inclined to inhibit or activate anything.

I do, however, try to ensure a good coverage of nutrients in which I include things like boron and lithium.

Hence at the moment I only take Rapamycin that would otherwise require a prescription and realistically should. 25OHD and Melatonin do require prescriptions in the UK, but IMO should not.

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I’m personally glad to read you started your statin again. I realize many of us would rather tackle our health issues naturally, but genetics are not fair, and one can do everything perfectly and still need medication….says the WFPB person with heart disease.

Here’s to your health!

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Rapamycin only has preclinical evidence.

Since you’re restarting the rosuvastatin, I would add in 10 mg ezetimibe and a PCSK9 inhibitor like 150 mg Praluent one time a month, if you want to kick the can down the road (until you can do it forever). Both of those further lower rate of events. If your doctors approve, of course.

“Natural supplement” seems like a bit of an oxymoron. Where in nature do you find a super concentrated amount of an isolated compound?

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DrFraser, just curious your supplement/pharmaceutical stack for longevity?

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It’s long.

Dapagliflozin 10 mg daily
Telmisartan 80 mg daily
Amlodipine 5 mg daily
Bempedoic Acid 180 mg daily
Ezetimibe 10 mg daily
Tirzepatide 2.5 mg weekly
Sirolimus 12 mg every 2 weeks
Vascanox HP 1 daily
NT Lipid power 1/8th tsp in water daily
Methylene blue 12 mg twice daily
NAC Ethyl Ester 100 mg daily
Glycine 1000 mg daily
Astaxanthin 12 mg daily
Lithium Orotate 10 mg daily
Taurine 6 grams daily
Coffee Cherry 1 daily
Black Cumin Seed Oil
Spermidine 10 mg daily
Vitamin D 5,000 IU + K2 MK7 200 mcg daily
Vitamin B12 500 mcg 4x/week
Omega 3 Fatty Acids, mix of DHA/EPA ~1.5 grams daily

This is from memory, I’m sure I missed a couple.

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This is great!

It reminds me to ask you and the group what the current thinking is on baby aspirin if you have known risk (high CAC score for me).

Years ago my cardiologist told me to take baby aspirin EOD.
Last week, my sister’s cardiologist told her to take it daily.

Thoughts?

Also, if one is on baby aspirin, would that make black cumin seed redundant or, in your opinion, are both fine together?

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For most individuals daily aspirin is not felt to be sensible on a risk/benefit. However, most of the complications are excess GI bleeding. Now there may be benefits with aspirin in addition to cardiac disease and stroke, such as reduction of colon, esophagus, stomach, and prostate cancer, and it also seems to have a small decrease in risk of forming deep venous thrombosis and pulmonary embolism.

USPSTF has a sensible guideline on this topic here.

On the Black Cumin Seed Oil, I think there are a number of health benefits with this. On this question with aspirin, I think Vera-Health.ai did a fair job as I’m pasting below. I don’t see any major contraindication to taking both of these together in most circumstances.

Black cumin seed oil, derived from Nigella sativa, is recognized for its potential health benefits, particularly due to its main bioactive component, thymoquinone (TQ). It has been shown to possess anti-inflammatory, antioxidant, and immunomodulatory properties. These effects are beneficial in managing conditions like cardiovascular diseases, diabetes, and chronic inflammatory diseases 24, 5.

Interactions with Aspirin: Aspirin, a nonsteroidal anti-inflammatory drug (NSAID), works by inhibiting prostaglandin synthesis and platelet aggregation (ASHP). While both black cumin seed oil and aspirin have anti-inflammatory properties, their mechanisms differ. Black cumin seed oil’s anti-inflammatory effects are largely attributed to TQ, which inhibits leukotriene synthesis and reduces oxidative stress 8.

Hmm crossing over the Dementia side of things, this study is very interesting, albeit it is data mined from the UK BioBank, but still seems a compelling association of decreased Alzheimer’s Disease in individuals on long term low dose aspirin.

Potential interactions between black cumin seed oil and aspirin could arise from their overlapping anti-inflammatory effects, which might enhance the overall anti-inflammatory response. However, this could also increase the risk of side effects such as gastrointestinal irritation or bleeding, a known risk with aspirin use (ASHP). Additionally, black cumin seed oil may affect the metabolism of other drugs, potentially altering aspirin’s efficacy or safety profile 2.

Given these considerations, it is crucial for patients to consult healthcare providers before combining black cumin seed oil with aspirin, especially if they are on other medications or have underlying health conditions. This ensures that any potential interactions are carefully managed, and the benefits of both treatments are maximized while minimizing risks.

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Speaking entirely personally I don’t like the idea of inhibiting cycloxygenase-1 (which inhibits the creation of prostaglandins). I have seen reports where this is not good for long term health. Obviously for some people it is useful given other problems, but I don’t see aspirin and other NSAIDs as being without negatives.

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If I am understand you and @DrFraser correctly, and I’m probably not!, you are both saying that for most people, a daily aspirin is probably not a great idea.

For people with known risk, like me, are you then thinking at that point it’s probably worth the risk, but maybe stick to EOD, or 3 days per week, but not daily?

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That’s really one for @DrFraser to advise on. There is definitely an argument for aspirin people with known risks, but I don’t personally know what the thresholds are for this.

I have experimented with Aspirin and I find it interesting to see how its effects fade over I think a 40 hours period, but I find it reduces melatonin production and I don’t personally like that.

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