#964

What has been your typical exercise regimen during the time you’ve been taking the medications?

#965

Body by science, which is one strength training day a week. The program believes one set to failure can maximize growth.

I’ve been on it for the past 4 years though, no change. And there has been no change in diet. I’m getting older of course, about to be 46. I guess growth can slow with age?

One difference is I’ve been taking glycine on/off which should actually help with growth I believe

The loss has been IMO slow but accumulative. I wasn’t sure at first, but its gotten to the point where its a bit noticeable

#966

If you’re worried about muscle loss and only strength training one day a week, most training literature would suggest that optimal strength training frequency would be at least 2-3 days per week.

That would be a decent place to start if you’re concerned about keeping a healthy amount of muscle as you get older.

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#967

Latest research says 10-20 sets per muscle per week ( higher volume causes even more gains but diminished returns and harder to recover from), only going to failure in the final set (otherwise “close to failure” for the other sets). Rep ranges from 5-30, even higher is ok but much more painful. Compound movements like the bench press count as 1 set for chest and 1/2 set for triceps, for instance. I follow Wolf Coaching on YouTube. He’s an actual PhD researcher who is actively publishing studies.

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#968

Sunshine4 refers to a training regime supported by the likes of Mike Mentzer and Dorian Yates, presently by a few trainers, where muscle hypertrophy is stimulated by providing an intermittent signal of maximum intensity, but low frequency, to allow for recovery.

Dorian Yates won 6 Mr Olympia with this method, whose drawback in my opinion is that it may overstress tendons, ligaments and joints and not be ideal at older ages. Injuries can be a real threat.

However, it has been shown to trigger hypertrophy, if executed correctly.

#969

The effect of SGLT2 inhibition on prostate cancer: Mendelian randomization and observational analysis using electronic healthcare and cohort data

Using Mendelian randomization, we found that genetically proxied SGLT2 inhibition reduced the risk of overall (odds ratio = 0.56, 95% confidence interval [CI] = 0.38 to 0.82; 79,148 prostate cancer cases and 61,106 controls), advanced, and early-onset prostate cancer. Using electronic healthcare data (nSGLT2i = 24,155; nDPP4i = 24,155), we found that the use of SGLT2 inhibitors was associated with a 23% reduced risk of prostate cancer (hazard ratio = 0.77, 95% CI = 0.61 to 0.99) in men with diabetes.

Powerful finding combining Mendelian randomization and longitudinal data: quite convincing. I wonder if we have animal models + potential mechanistic pathway as well.

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#970

I may have misunderstood the original poster, but Dorian Yates worked out 4 days per week, not just one. Only 1 day per week of strength training will very likely not be enough to maintain adequate muscle as we age.

1 Like
#971

sluggerT80, yes yesterday I listened to Dorian Yates’ podcast interviewing Peter Attia, he says he trained about that amount but one hour per session. Compared to other Olympians, that’s a tiny amount.
I also searched Hi-intensity workouts when I started training again 7 years ago.
What follows is OT but maybe clarifies some concepts.
The rationale is to train at extremely high intensity, few sets and then rest to recover. Good for busy people. I read Mike Mentzer, I read other trainers, but I gave up searching soon after I realized that hi intensity means just that, lifting the highest loads to yield the highest growth signal, then resting no matter how long it takes.
This is not what the eminent authors in this field, like Brad Schoenfeld, suggest. Also, I think it’s not at all suited to more aged people. Dorian Yates underwent several injuries.
One of the bodybuilders who aged best is maybe Lee Haney, who would lift relatively moderate loads.
Presently, I follow a highly individualized scheme, lifting many sets to failure, but only the loads which do not cause any pain, ache or inflammations to my muscles and tendons.
I wish I could lift heavy weights for hours and recover expeditiously but at 64, having undergone 25 years of inactivity and an existing hernia I understood I must cool down substantially.

#972

I wouldn’t follow the personal training advice of professional bodybuilders on anabolic steroids unless perhaps you’re also taking anabolic steroids. I’d follow the research that is actually published in peer-reviewed scientific journals on subjects who aren’t taking steroids. See my post above for summary of the very latest.

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#973

I agree and my best suggestion for a reading is Brad Schoenfeld’s book. I don’t know Wolf coaching but he says just about the same things written in the book (I have the 1st edition).

image

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#974

Yep Schoenfeld is pretty much THE guru of hypertrophy training and I have both editions of his book. Wolf knows him and has interviewed him, but Wolf also is carrying the torch and publishing new stuff.

1 Like
#975

I intend to get on empagliflozin, as my blood glucose numbers are steadily getting worse despite my best diet/lifestyle efforts. My numbers right now are prediabetic, moving toward diabetic, FBG in the 110-115 range in the morning, A1c 5.9; this has been going on for 5 years or so, every year getting worse. At one point I was on metformin 500mg/day, which did absolutely nothing. I stopped the metformin, because I don’t like what the alleged effect is on exercise. I’m a 66 y/o caucasian male, and I intend to get on acarbose first, which I anticipate will do very little for my glucose control, and once I establish that after another A1c test 90 days later, I will get on 10mg/day empagliflozin. I anticipate that will happen next year soon after I turn 67.

In case empagliflozin is well tolerated by me, and has a favorable effect on my FSB and/or A1c, I was wondering how people use it - in particular, is there any indication as to how LONG TERM use works, and do people take breaks from use, or what. FWIW, I don’t have any medical conditions, only my lipid, BG, BP numbers are all moving in the wrong direction, so I want to nip it in the bud. TYIA!

#976

New study fresh off the press showing that tirzepatide virtually eliminated progression from pre-diabetes to diabetes (by 94%!!!). Also reduced blood pressure and average weight loss was 20%

Of course, it’s also a lot more expensive than dapagliflozin and requires a weekly injection.

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#977

Thanks, Davin8r. Unfortunately, while it looks like a great drug, it has the same practical obstacles like PCSK9i, too expensive for out of pocket, not approved for me by insurance, and not available through Indian pharmacies (and being an injectable, tricky in mail delivery).

So for now, SGLT2i it is, especially that there is some support based on ITP results.

3 Likes
#978

SGLT2 inhibitors for patients with type 2 diabetes mellitus after myocardial infarction: a nationwide observation registry study from SWEDEHEART

The primary outcome measure was a composite of death and first hospitalisation for heart failure after one year analysed using an adjusted Cox regression.
SGLT2 inhibitor use was associated with lower rates of the composite outcome (hazard ratio (HR) of 0.70 (95% confidence interval (CI) 0.59–0.82).

Also, more and more papers suggest that metformin should be abandoned as a first-line treatment for diabetes and replaced with SGLT2i and/or GLP-1RA: [Drug therapy of type-2-diabetes-is metformin dispensable now?] - PubMed

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#979

I was reading with interest but weight loss to me would be a major drawback, since I struggle not to go catabolic.

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#980

It will be interesting to see more research on the GLP/SGLT2 drugs and body composition. I’ve been doing low dose tirzepatide to lose body fat, and it’s worked extremely well (hello 6-pack!) BUT I do think I’ve lost some lean mass despite my best efforts of protein intake and resistance training. I’m getting a DEXA body comp scan Tuesday to find out exactly what the changes have been.

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#981

Let us know the results, I’m very interested in this.

Regarding SGLT2, apparently they reduce muscle mass but they lower fat more so the fat % improves: Effect of SGLT-2 inhibitors on body composition in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials 2022

18 studies with 1430 participants were eligible for the meta-analysis. SGLT-2 inhibitors significantly reduced body weight(WMD:-2. 73kg, 95%CI: -3. 32 to -2. 13, p<0. 00001), body mass index(WMD:-1. 13kg/m2, 95%CI: -1. 77 to -0. 50, p = 0. 0005), waist circumference(WMD:-2. 20cm, 95%CI: -3. 81 to -0. 58, p = 0. 008), visceral fat area(MD:-14. 79cm2, 95%CI: -24. 65 to -4. 93, p = 0. 003), subcutaneous fat area(WMD:-23. 27cm2, 95% CI:-46. 44 to -0. 11, P = 0. 05), fat mass(WMD:-1. 16kg, 95%CI: -2. 01 to -0. 31, p = 0. 008), percentage body fat(WMD:-1. 50%, 95%CI:-2. 12 to -0. 87, P<0. 00001), lean mass(WMD:-0. 76kg, 95%CI:-1. 53 to 0. 01, P = 0. 05) and skeletal muscle mass(WMD:-1. 01kg, 95%CI:-1. 91 to -0. 11, P = 0. 03).

See also: Effect of sodium-glucose transporter 2 inhibitors on sarcopenia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

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Parkinson's disease
#982

When you’re on negative calories, you almost always lose a bit of lean muscle. Unless you are using anabolics/testosterone or have just started gym training. Experienced natural ”bodybuilders” always lose a little muscle mass with diet.

So could this be largely due to the caloric deficit?

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#983

Hopefully! I was just hoping I could hold onto all the good stuff :grin:. I’m sure the pro bodybuilders are experimenting with GLPs during their cutting phases to make them less miserable, so I wonder what their experience has been?