Almost every drug tested in NIA ITP works via mTorC1 inhibition or mTorC2 activation
- Rapamycin increases lifespan in mice because it inhibits mTorC1 in both sexes
- 17 alfa estradiol increases lifespan in male mice only and it inhibits mTorC1 (but it doesn’t inhibit mTorC1 in female mice)
- Canagliflozin increased lifespan in male mice only and it inhibits mTorC1 in male mice only
- Acarbose: activates mTorC2 and inhibits mTorC1 (more strongly in male mice)
Do we have any way to measure levels of mTorC1 and mTorC2 expression in humans?
约瑟夫
#2
There was a posting started on 23 February, 2022 on this subject see link below;
All is off the shelf equipment, cost to do this in the USA is in the $4,000.00 range.
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