Caloric restriction

[Neo]

@DrFraser Agree that the aging clocks are still early. Was not anchoring to that specific result, but more around the overall health benefits they found in the Yale clinical trial (documented in several of the other papers).

Also def not saying it is CR vs rapa/molecules. It does not at all have to be an “or” but can be an “and”. Actually think some of the longevity molecules, eg Acarbose and SGLTi’s, can help achieve some amounts of CR with less difficulty.

[AnUser]

@DrFraser

#2 Get an initial whole body composition DEXA and repeat it in a few months, %body fat and visceral fat would be confirmatory.

@DrFraser

until at a steady state, at a body weight that is likely less than ideal (e.g. you are likely to live longer, but be a bit miserable)

@DrFraser

I’d however think the proof of CR is a body weight/composition that is significantly less than starting point, as it would be difficult to have CR that was effective without having these changes.

There is an error here as this is not CR for longevity as I understand it.

CR is reducing calorie intake so metabolic rate, calorie output or burn decreases so weight loss does not happen. Otherwise you would starve to death as you keep rebalancing the CR for the new weight.

[DrFraser]

I was talking about the transition from doing whatever one is doing now to having CR comparatively.
If you simply want to do an estimated calories based on IBW for a sensible body composition based on gender and height there are formulas for that - but also would need to modify for activity.
Measuring the effects, I’d favor DEXA, but you can increase body fat % if you primarily lose muscle and vice versa.

[AnUser]

I was wondering about markers of being in this CR longevity state where metabolic rate slows down. Body temperature could be one of those.

[DrFraser]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117452/
This one above shows decreased temperature.

The one below shows no consistent effect with BP or HR despite literature contrary suggesting on average both should go down.
https://pubmed.ncbi.nlm.nih.gov/29518898/

[desertshores]

FWIW: Several temperature readings were taken at my primary providers office and two at my dermatologist’s office (testing for Covid) in the last 18 months. They ranged from 97 to 97.6 degrees f.
That is a little below statistical averages, so if that is evidence of CR, maybe my calculations were correct.

[dwglinn]

Practicing a caloric restriction, but nutrient dense diet provided amazing results. After eight months, I started taking rapamycin and was quite impressed in the amount of energy, clarity and overall sense of well-being. I experienced only 10 weeks.
Bear in mind I am 69 years old having had double aortic valve replacements, two bouts of bacterial endocarditis requiring 12 weeks of antibiotic therapy twice. I have been in and out of the hospital over the last several years and in hospice twice. Practicing caloric restriction with intermittent fasting definitely improved my overall health, although I was still fighting, a chronic undiagnosed malady no doctor has described it as bacterial, viral or auto immune. Either way it seems that Rapp myosin is targeting this malady or it has improved my immune system enough that I can actually feel it targeting this unknown disease. I definitely believe my immune system And circulatory system have improved, even though I was physically active before.
I recommend anyone who is considering taking this medication to find a reputable telemedicine company. If they don’t request a blood test before prescribing this medication, I would not be too convinced of their credibility. I stumbled onto Ageless RX and the first thing they did after I paid my hundred dollars was to arrange an appointment for a blood test Close to my house. I expected to pay an additional charge, but it appears Ageless RX incorporates the cost of the blood test and the medication at $100 a month. That combined with their excellent customer service has made me a lifetime customer.

[Flooshy]

Valter Longo promotes fasting on his website so I don’t really know what you mean.

[mccoy]

I tried CRON for a year, here in the silicon valley when the trend first started. One of the CR mailing list members wife started a small business selling the premade meals from Walford’s book and for approximately six months I was eating about 30 percent fewer calories. I lost a lot of weight, had to wear a sweater even in the summer, and was constantly hungry. There are definitely some negative side effects.

I think the reason people/ researchers have given it up is it’s really hard, and likely appeals to a very small portion of the population in the USA.

By the way, -30% is probably way too much, Crers in the CR society forum, before it shut down, were discussing about t a -10 or 15% optimum, harder CR maybe causing excessive frailty, impairment of immune system, glucose intolerance.
My point about CR is that it may not be suited to everyone. CR is undoubtedly very good for overweight people who want to lose progressively weight, whereas some other people have problems not losing weight.
Like myself. And I hate to look too frail or slim, having a preference for a muscular phenotype.

By the way, Valter Longo, the eminent gerontologist, is against CR, whereas Luigi Fontana, another eminent gerontologist, is very much in favor of it. Go figure!

[RPS]

@RapAdmin

lost a lot of weight, had to wear a sweater even in the summer,

A good strategy if heat waves become worse if CR makes one feel colder than average.