#89

Hello @Dr.Bart What are they recommending for breaks and cycling?

#90

An interesting post from Twitter on dosing is the key:

Screenshot 2024-11-15 at 10.36.48 PM
Screenshot 2024-11-15 at 10.36.48 PM1202×580 108 KB

https://x.com/winslow_strong/status/1857388108351774929

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#91

In mice it is hepatic insulin resistance that is key. There may also be a beta cells thing.

It would be nice if someone could do the same experiments as me with similar testing we could then have a better idea of what happens at each stage in dosing.

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#92

The ideal age to start with rapamycin also depends on one’s gender. Women, who want to prevent menopause, might have to start earlyer then men. The whole longevity topic differs between men and women, because we aquire a lot of damage bc of menopause.

As there is and will be much more research for men’s longevity, we women will have to take what we know now and wait for news much longer than men.

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#93

New idea: do we believe BJ is stopping rapamycin? Maybe he isn’t, but sais so.

I was thinking that his supps are not outstanding and might not have any huge impact. Rapamycin could be the only thing thats working in his stack, but is hard to sell. So why not telling people that you stopped the chemical thats giving you the benefit and pointing to the stack you can easily sell?

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#94

@RapAdmin

Wish there was more info, but here is what I saw and posted a while back

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#95

They are also fundamentally different in key ways

  • Rapa is pro-hunker down, conserve, decrease growth pathways, recycle and a family of things that may be more “longevity” and less “short term health/feel/look good”

  • HGH is pro growth, pro expand, pro build and may feel and look good in the short/medium term, but is less likely to be pro long term longevity

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#96

I’m a medic with autoimmune myocarditis for 20 years on methotrexate with mild neutropenia.
Last 7 years taking longevity supplements: nad boosters, senolytics
16 months ago was able to stop methotrexate with weekly 6mg rapamycin but had 6x severe skin infections mostly treated with antibiotics. This did not happen while on methotrexate or on nad boosters and senolytics.
Finally 4 months ago stopped rapamycin and started peptides to boost immune system: kpv, thymosin alpha 1, Bpc157, tb500.
No more infections but early days for conclusion.
Started again 3mg rapamycin every 2 weeks when not exercising for 3 days off protein shakes, creatine etc.
As I am now autoimmune free for 16 months without methotrexate the infection episodes were worth it and I seem to have modified disease.

My plan is to cycle rapamycin 3 months on 3 months off with above regime to avoid autoimmune return and chance of longevity effect. It must be said that I take rapammune licensed, so proper strength.

I will also continue cyclical nad boosters, senolytics and subcut peptides.
Sugar and proccessed food free lifestyle has also coincided with this period so maybe all of above had neutral effect or additive effect.

My point and recommendation is to consider rapamycin as an ingredient in the cooking process that is longevity. I see no problem with starting and stopping and adjusting to unique circumstances.
My blood profile, lipids, HbA1C, CRP and others except neutrophils (left over from methotrexate) are all perfect so worth checking regularly as experimenting.

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#97

After going at this for a year, I suspect I am quite sensitive to Rapa in its effects on my immune system.

I tried 8 mg every week and got a lot of bad effects. Then took a break and am now at 4 mg every other week for three cycles, then two weeks off. I am very willing to lower even more.

I suppose there is a concern that it is not enough to trigger optimal autophagy, but its the best balance for my health IMHO.

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#98

Good insight. Got to stop for some time prior to any surgery I suppose.

Maybe one month before?

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#99

Mike Lustgarten gave Bryan Johnson some new data to question Rapa use it seems as he also had problem with resting HR.

Why does Kamil want Bryan Johnson to take rapamycin so badly? Seems dogmatic. It might work sure, but maybe it’s for future investigation, in a different form or mTOR inhibitor, dosing, or whatever.

Data is what we mostly have. You can argue that someone would want to take it despite a worsening in blood biomarkers or other stats.

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#100

These are all biomarkers. What do they mean? We know individually, but what in aggregate? What do we even measure? A bad glucose marker, we understand. But what of bad glucose control in mice, yet longer lifespan - do we take that deal, net outcome-wise? What about that RHR, in isolation vs net total effect? In humans? In you?

If all you had to go on is change in one or a handful of biomarkers would you continue with rapa for mice?

What do we do when we have no real way to measure the global net impact of rapa on health or lifespan, do we stick with single biomarkers like RHR? For some things, the decision is easy - if you have nasty infections indicating a compromised immune system, you adjust or quit rapa. But what about a more ambiguous elevation of RHR of a few beats per minute? How do you net that out?

I honestly don’t know, so I’m not going to question anyone’s decisions wrt. rapa either way. I intend to measure all I can, including how I feel subjectively and experiment.

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#101

It seems like I’m one that doesn’t experience any lipid, heart rate/ HRV or glucose (only a transient increase in the first 24 hrs. post dosing) issues from rapa. All of those have actually improved for me but I’ve also majorly cleaned up my diet since starting rapa. I probably wouldn’t have been able to improve my diet much though without the improvements to my gut from rapa. All I know is that for me personally I have chosen to continue it and would regardless for the gut benefits alone. 1-2 mg every 10 days seems like my sweet spot but I’m pretty small. I’m grateful for rapa even if it turns out to not have any anti-aging/longevity benefits because it’s improved my quality of life. I think it is quite possible it does though because I felt like I was getting old very fast before starting it and now my aging seems almost imperceptible.
I made a decision 3-4 years ago to not take influencers or people trying to sell me something too seriously. I greatly appreciate people here sharing the best science we have and their personal experiences though. We all have our own unique context to consider when making health choices after all. Having a dog who made such a remarkable turnaround also made quite a strong impression on me (and my husband) to give it a try even though we aren’t dogs! :rofl:
I respect Bryan’s choice but at the end of the day it doesn’t change mine.
I’m just aiming for healthspan=lifespan and hope to be doing human zoomies and go gently in the night like @drfawn’s doggy when it’s my time. I don’t even really care about looking young but just want to glow with health and vitality for as long as possible.

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#102

Just a thought…BJ takes a 100 supplements… has an incredible rigorous exercise routine, sleep monitoring… erection monitoring… blood injections from his son, all kinds of skin treatments… claims relationships with him are impossible, etc.

I have to think that… this one molecule - rapamycin - does as much or even more than his whole combined Blue Print.

Perhaps… throw the Blue Print out… and if you just took a little rapamycin weekly you would be competitive to live as long and as healthy as he does with all that intervention and then trying to live a typical normal life.

BJ certainly is doing more for longevity than it seems actually living… and enjoying life’s journey at times. I’m thinking I’ll probably outlive him… with strength and health to boot.

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#103

Exactly what I have been saying, Bryan Johnson takes over 100 supplements daily. Many supplements have anti-inflammatory effects and some like curcumin and gingerol directly inhibit m-tor.
His approach is far from scientific, it’s a kitchen sink approach.
Which is fine, he’s free to do what he wants but then having him create a blueprint for others to follow based on his million dollar see what sticks plan is preposterous.

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#104

Any overweight genX who’s been prescribed a statin will outlive BJ.

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#105

silicon valley and capitalism is always about adding and doing more and more, never about less unfortunately

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#106

Bezos, for one, is fully banking on the Yamanaka factors.

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#107

Bryan Johnson does too many purely cosmetic things to really know what is happening.

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#108

Look up Attia and Kaberlein’s protocols.

1 Like