#271

What?!
RAPAMYCIN CAUSES CAN CAUSE REAL BACTERIAL CUTANEOUS INFECTIONS = KNOWN RISK
RAPAMYCIN HAS NOT BEEN STUDIED IN YOUNG HUMAN BEINGS (AT ALL STOP SHOWING ME THE ANIMAL STUDIES) = UNKNOWN BENEFIT

REAL RISK>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>UNKNOWN BENEFIT for 20 year olds.

If you want to convince someone of your position, it always helps to not sound like an unhinged trainwreck…

2 Likes
#272

My resting HR as never been lower - now at 42 (was in the 50’s when I started) and my HRV has never been higher at 75 ( 3 years ago it was in single digits) after 5 years on rapa 10 mg every 10 days. I track my biometrics every day on a spreadsheet so no recency bias to my data.

10 Likes
#273

Thats really good information.

Do you see a bump in RHR (and decrease in HRV) in the hours and days immediately after dosing, or no movement in these numbers (or do you not track them on a regular basis day by day, hour by hour via Oura ring, or Whoop, etc.?

#274

Do you take Rapa with any enhancers (i.e. grape fruit, or EVOO) ?

1 Like
#275

“Also I’m planning on taking cat’s claw because of that study”

Could you point to that or say what the study said?

#277

Check out this study cited in OP’s post:

Keep in mind “AC11” is cat’s claw.

#278

Are there other things you’ve done to improve your HR and HRV?

Congrats!

#279

no I do not - just take it straight up
I’ve had it measured 90 minutes after ingestion and gotten quite high levels

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#280

Exercise, earlier to bed, reducing inflammation, listening to binaural beats before bed

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#281

Why not take 6mg per week for 60-90 days a year? Then none the rest of the year?

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#282

Everyone is welcome to try whatever they want. Generally, right now, the dominant theory in the scientific community seems to be that mTORC 2 inhibition is what causes many of the undesirable side effects people see with rapamycin; immune suppression, lipid and glucose dis regulation.

mTORC2 suppression happens with frequent and “high” dose of rapamycin; the more frequent and longer, the greater the probability of this inhibition. There is no simple clinical way to measure this, so you’re sort of driving in the dark with this right now.

So, generally, its better to spread out the dosing and with do “lower dosing” - of course the big issue we all struggle with is dosing is also individual (responses vary by person), and its complex.

Anyway - read up here: Evidence that mTORC2 inhibition is detrimental, by Dudley Lamming

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#283

The inhibition of cell division whether by complex 1 or 2 would generally be unhelpful unless the objective is inhibiting the immune system.

I was planning another high dose yesterday, but have held back for now. I want to see a few markers move before taking another high dose (particularly GGT, but also track quality of sleep).

#284

Interesting, maybe I’ll try that.

#285

@RapMet
I wish I could agree but it seems my body likes a constant dose of rapamycin to function properly… hence for now I will stick to weekly 2mg. I was doing 20mg weekly before for about 6-8 weeks earlier…

@RapAdmin
I am sure I had mTORC 2 inhibition before, I remembered my 24 hour blood test was like 40ng/mL. I can’t say anything bad about it as I did not really notice anything weird.

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#286

Thx for this,

From what you gathered at your latest longevity conference, or other sources, do most people still seem to be thinking aprox 6mg once per week is the most common approach? Or are people now more commonly leaning towards every two weeks?

I’m 105lbs and taking 6 once per week.

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#287

We are similar as I too have psoriasis, which is a disease caused by an overactive immune system.

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#288

Is using AD HOMINEN a better way?

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#289

Thanks Paul. Any suggestion on good source for this? What protocol do you use?

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#290

Just search YOuTube for the term binaural beats and you will find many videos

#291

Hi again @Paul That would lead me (and others here) to just randomly selecting what to listen to. So I was hoping you might share what has been best in your experience - given your success on the heart rate and variability data.

(No worries though, with this current list I just wanted to provide color on why I think the question was valuable - for me to ask, and perhaps/likely for others on the forum to see the answer to.)