These programs are aimed at people with very high financial resources who need very little additional utility for the considerable dollars spent. Actually the programs are mostly about recommending excellent nutrition and exercise programs to the participants. I believe many people on this forum provide themselves with 99% of the benefit of these programs on a do it yourself basis.
7 Likes
I am not sure the programmes provide that much benefit.
OTOH if you have an income of say USD10m pa, then you might as well try some of these.
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RapMet
#265
I am tempted to believe these programs are for people who have never heard of Google or YouTube lol.
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adriank
#266
I guess it depends what your goal is. I just want to stay independent without pain and suffering. I’m not concern if I drop dead tomorrow. So far rapamycin has helped me a lot. However since reducing my dosage, I notice certain reversal. It makes me wonder if the optimum dosage for everyone is different. I’m going to stay on a low 2mg a week with GFJ for the next 3 months and reassess the situation. I would have preferred a fortnightly regiment but weekly seems to give me better relief from allergies. May be my immune system is fried by something and needs a bit of help calming down. At one stage I was getting over 40ng/mL @ 24 hours which is very high for weekly dosage. Now I’m targeting 3-4ng/mL after 48 hours. I’ll document my experience and if it is not satisfactory I’ll double it for the next 3 months.
My typical meal with GFJ 3 hours before my dose.
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@Beth, I didn’t move forward to the next step, but it does require visits to Seattle. They mention it “includes quarterly retesting,” and from the description, it seems like a rather tailored approach based on the individual’s goals and results.
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I think we see the reason for the reductions in HRV see with rapamycin here:
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Randy
#269
Have any users of Galantamine observed positive effect on HRV. Will taking it along with rapa dose counteract the Hrv side effect.
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jnorm
#271
What?!
RAPAMYCIN CAUSES CAN CAUSE REAL BACTERIAL CUTANEOUS INFECTIONS = KNOWN RISK
RAPAMYCIN HAS NOT BEEN STUDIED IN YOUNG HUMAN BEINGS (AT ALL STOP SHOWING ME THE ANIMAL STUDIES) = UNKNOWN BENEFIT
REAL RISK>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>UNKNOWN BENEFIT for 20 year olds.
If you want to convince someone of your position, it always helps to not sound like an unhinged trainwreck…
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Paul
#272
My resting HR as never been lower - now at 42 (was in the 50’s when I started) and my HRV has never been higher at 75 ( 3 years ago it was in single digits) after 5 years on rapa 10 mg every 10 days. I track my biometrics every day on a spreadsheet so no recency bias to my data.
10 Likes
Thats really good information.
Do you see a bump in RHR (and decrease in HRV) in the hours and days immediately after dosing, or no movement in these numbers (or do you not track them on a regular basis day by day, hour by hour via Oura ring, or Whoop, etc.?
RapMet
#274
Do you take Rapa with any enhancers (i.e. grape fruit, or EVOO) ?
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Ulf
#275
“Also I’m planning on taking cat’s claw because of that study”
Could you point to that or say what the study said?
Check out this study cited in OP’s post:
Keep in mind “AC11” is cat’s claw.
Neo
#278
Are there other things you’ve done to improve your HR and HRV?
Congrats!
Paul
#279
no I do not - just take it straight up
I’ve had it measured 90 minutes after ingestion and gotten quite high levels
1 Like
Paul
#280
Exercise, earlier to bed, reducing inflammation, listening to binaural beats before bed
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Denet
#281
Why not take 6mg per week for 60-90 days a year? Then none the rest of the year?
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Everyone is welcome to try whatever they want. Generally, right now, the dominant theory in the scientific community seems to be that mTORC 2 inhibition is what causes many of the undesirable side effects people see with rapamycin; immune suppression, lipid and glucose dis regulation.
mTORC2 suppression happens with frequent and “high” dose of rapamycin; the more frequent and longer, the greater the probability of this inhibition. There is no simple clinical way to measure this, so you’re sort of driving in the dark with this right now.
So, generally, its better to spread out the dosing and with do “lower dosing” - of course the big issue we all struggle with is dosing is also individual (responses vary by person), and its complex.
Anyway - read up here: Evidence that mTORC2 inhibition is detrimental, by Dudley Lamming
6 Likes
The inhibition of cell division whether by complex 1 or 2 would generally be unhelpful unless the objective is inhibiting the immune system.
I was planning another high dose yesterday, but have held back for now. I want to see a few markers move before taking another high dose (particularly GGT, but also track quality of sleep).
RapMet
#284
Interesting, maybe I’ll try that.
