#474

no, that was two scans plus advanced AI analysis

2 Likes
#475

The idea that COG should determine the retail price is absurd.

1 Like
#476

And now this…

I’m 47 years old chronologically; my heart is 37

https://indianexpress.com/article/lifestyle/health/bryan-johnson-reverse-ageing-different-organs-physical-health-9791291/

Byran… you can then say, now we have a situation where the heart is 37, can we get the heart to be 36 or 35?

Got you there buddy…

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According to two Coronary Calcium Scans… at almost 67 years… my heart is that of someone less than the age of 35.

I think my ears are younger than his too… lol.

8 Likes
#477

Finasteride or something made you heart disease free, this should last until chronological age 90+ or something.
Did you do any scans to look at soft plaque so there’s nothing dangerous there?

3 Likes
#478

Yes, I have taken a daily dose of finasteride since about 33 years old… we are just seeing its benefits in reduced prostate… keeping one’s hair… and in latest studies… it manages cholesterol in the blood. Win…win… win.

Just had my finasteride… tadalafil and minoxidil - my before bed medications.

I want to do a Cleery for soft plaque… right now takes multiple visits to a center… then a doctor… and the cost… not making it really practical. Maybe in a few years.

4 Likes
#479

VO2max of 64.29 is pretty insane, especially at his age. He must be doing something right, at least his consistent exercise.

https://x.com/bryan_johnson/status/1892287231521673528?s=46

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1 Like
#480

For what reason did he target increasing it further? Or was this a byproduct of another optimal exercise protocol, for example?

What does this mean from his post?

5x higher survival rate being in the top 2.5% of VO2 max in your age bracket

#481

Yeah, not to pile on but what if everyone in his age bracket finds out about this and they all improve by 24%? Does he need to try harder and still be in the top 2.5% of that new group in order to get the benefit? Doesn’t make sense.

1 Like
#482

Bryan Johnson, the American entrepreneur renowned for his anti-ageing endeavours, has disclosed the details of his latest self-experiment. Building on his previous experiences with plasma exchanges and stem cell injections, Mr Johnson took an unusual step by injecting himself with ketamine, a horse tranquillizer, and monitored his brain activity for 15 days to investigate its effects. The entrepreneur described the effects of the anaesthetic on his brain activity, stating that the patterns became “completely scrambled” after administration.

“I injected the horse tranquilizer Ketamine and tracked my brain data for 15 days. It completely scrambled my brain. In a world-first, we answered the question ‘What happens to the brain before, during, and after ketamine treatment?’ We also discovered how long it took for my brain to return to ‘normal’. The results surprised me,” the tweet read.

2 Likes
#483

Is that a scientific description? what is the definition? is a scrambled brain desirable? 15 days to unscrabmle ? LoL!

So many questions…

1 Like
#484

Scrambled is actually somewhat accurate, as drugs like ketamine temporarily interrupt deeply ingrained activity patterns, allowing new pathways to activate and others to quiet down. This can be good or bad - I think it all comes down to what one is doing alongside the psychedelic intervention.

I wish Bryan would talk more openly about his use of psychedelics. He is clearly enthusiastic - he has a tattoo of the 5-MeO-DMT molecule and a former girlfriend has spoken to reporters about their shared use of psychedelics. Have they been helpful? Does he consider them an important part of his longevity stack?

5 Likes
#485

I’m somewhat familiar with psychedelics, my comments were mostly tongue in cheek :slight_smile:

In the 70’s LSD was my psychedelic of choice :slight_smile: many, many, many trips… the things I’ve seen!! LoL!

Been micro-dosing golden teacher a couple times a year for the past 5 years and have a good routine around that…

I don’t really consider THC a psychedelic but I do take 3mg in an oral oil product every evening to help with sleep. Don’t get much from CBD so I stick with 99% THC

3 Likes
#488

This was a reply to a post that has been deleted and I don’t know any other way to get rid of it.

#490

I really don’t care about Bryan Johnson’s social life; it really has nothing to do with longevity science, and here is not the best place to discuss it.

5 Likes
#491

I respect what Bryan is doing, but honestly I suspect he gets a lot of shitty advice. He always talks about the large team of experts, but I don’t think he’s shared who they are. The only public facing one is the British guy who appeared in the documentary, and that guy has barely just finished medical training.

I also have to strongly suspect he’s using some medications which he doesn’t fully disclose. He claims an Apo(a) of 3 mg/dl, and ApoB of ~30. I don’t see either of those numbers as achievable without pharmacological intervention- especially when they have not always been that low, so he’s presumably not some genetic freak.

VO2max of 60+ is quite incredible though IMO, which reflects how hard he works at this.

As always, be careful of any influencers. And when Bryan starts selling supplements it makes me even more cautious in some way.

6 Likes
#492

ApoA of 3 is incredibly low - is this correct?

#493

If it’s apolipoprotein(a) that’s common to be low in 70% of the population

#494

I share the same reservations about his testosterone levels. Given his resting body temperature due to CR, his hypothalamus must be impacted. I can’t reconcile that with a testosterone level of 1000. I wish he would share his LH/FSH levels, and I wonder if he doesn’t because they’re low which would be an indication that he’s using something to boost testosterone (whether that’s HCG or Testosterone).

I suspect there’s a reason he only chooses to share ~20 biomarkers when he’s the “most tested person on earth”

5 Likes
#495

That’s really interesting. Do you have a link to anything? All I can find is vague reference ranges saying < 30 is “normal”, which isn’t very helpful. Does that imply that this is a biomarker which is not normally distributed? i.e. 70% of people have super low levels, and ~20% have levels (over 30) which put them at risk?

In this behemoth summary from the AHA I can’t find any sort of population distribution numbers. But the graphical abstract seems to show a very low mean?

(FWIW, I am seemingly cursed, and my Lp(a) was 65 mg/dl on the last test, urgh

Yeah, that too. Every time I cut calories, my total testosterone falls.

2 Likes
#496

My Lp(a) is 9, which is low and is associated with reduced risk of CVD. However my CAC score is very high, which is associated with elevated risk of CVD. How to interpret such contradiction? Asked my cardiologist but it seems he doesn’t know.