Excellent post tong! Might be post of the year. I mean that seriously. In fact it can be an useful resource to link for beginners and those of us who need reminders.

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If you are over 30yrs.old, a sure way to make yourself look older is to get below 10% body fat, especially if you have ever been significantly overweight.

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Beating the average hedge fund is easy. So is making lots of money on biotech stocks. This year has been fantastic for that already as was last. You can trade options around significant events using leverage to create significant returns. I wont go into it more than that as I dont want too many novice traders to lose their shirts. Unless they look like Bryan Johnson. :wink:

I had to tie the topic in somehow.

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Over testing
Over diagnosing
Overreacting

But I do have a good pill for OCD!

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I gotta say…At first (and second!) glance Bryan’s regimen is A LOT. But, the description of his Why and the discussion about the journey so far (from Blueprint website) is endearing. And, although I personally wouldn’t have opted for a Vegan diet, it’s hard to argue with his current labs and diagnostics. They are excellent.

Also, if you haven’t had an IPL treatment you may not appreciate how very uncomfortable doing it to your entire body every week would be! Yikes!

Keep us updated @Oliver_Zolman_MD !

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So, i am assuming this is what Bryan is using. I learn something new every day here…

Or

Effect of aging on quality of nocturnal erections: evaluation with NPTR testing

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Paper: Effect of aging on quality of nocturnal erections: evaluation with NPTR testing | International Journal of Impotence Research

Nocturnal penile erections: the diagnostic value of tumescence and rigidity activity units

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Paper: Nocturnal penile erections: the diagnostic value of tumescence and rigidity activity units | International Journal of Impotence Research

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It’s cool/crazy tech for sure. FirmTech has only been available for about a year but it’s a neat little device. If we’re quantifying everything else … Why not erections?

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Are there different kinds of IPL laser? Aren’t they usually used for hair removal? Does that mean that Bryan is sans hair on the areas he’s treated.

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There are a few ways to use them but he’s using IPL to get rid of sun damage and keep the skin youthful. It feels zippy, like zapping your skin with a rubber band over and over again. Definitely not fun in sensitive body areas!

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I would love to see the reasoning behind each of the supplements he takes

Some data on IPL and its uses and costs:

An IPL device works by delivering an arc of light energy that penetrates all levels of the skin, without harming the surface (the epidermis), so there’s little to no downtime afterward.

This light treatment can be performed on the face, hands, neck, chest, and legs. The size of the head of the IPL device is usually larger than most laser spot sizes, which allows for rapid treatment of large body areas.

Most people need a series of IPL photofacial treatments to see optimal results. They’re typically performed three to four weeks apart

More information and pricing:

https://www.realself.com/nonsurgical/ipl

Yes, and different settings on the device depending on what you’re treating.

I would donate 400K to this trial to finally see Rapa effect on humans

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Great to hear - we need a lot more clinical trials on rapamycin, and I hope this is a good start!

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I would love to sign my Dad up for this trial

There are a few things mentioned in the Bryan Johnson protocol that I’ve not heard about and know nothing about. If someone who knows what he’s talking about, or knows more about the therapy or testing, please post.

Specifically:

  • fat injected into his face… a series of injections to build a “fat scaffolding” in his face that would produce genuine, young-person fat cells. (What is the official name for this treatment procedure?)
  • I inserted my arm into a cardiac health monitor on Johnson’s kitchen island. The machine buzzed and whirred for a few seconds, then reported back that my ticker—at least by one measure—wasn’t that far off Johnson’s. (What is this “cardiac health monitor”?)
  • Threshold Sound Conditioning - is this something that people can do themselves?
    (study referenced: Randomized Controlled Trial Evaluating Threshold Sound Conditioning in the treatment of Sensorineural Hearing Loss (S26.006) | Neurology
  • Anyone know what brand this device is below and what it does? It looks like some sort of LED device.

Ah - I think the above device might be this: Dermalux Flex MD LED Light Therapy Device, About $2,500 but I’m sure lots of lower costs alternatives out there. The technology seems pretty basic.

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This is a “standard” used cosmetic surgery procedure.

Has been used for quite some time.

Review link;

Facial Fat Grafting | Cosmetic Surgery | Stanford Medicine.

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Ah - I think I’ve found it - thanks! Never heard of it.

Facial Fat Transfer

Facial fat transfer is a minimally invasive plastic surgery procedure that uses your own body fat from your hips, thighs, or stomach to add or restore volume to your face.

Also known as facial fat grafting, fat injections, or lipofilling, the procedure can restore cheek volume, plump thin lips, and smooth deep nasolabial folds and marionette lines. It can also improve the appearance of pitted acne scars.

This multistep outpatient procedure involves extracting fat from one area of the body via liposuction, processing the fat cells with a centrifuge or filter, and then injecting it into the treatment area in tiny droplets (often called “microdroplets”) to plump, lift, smooth, and reduce signs of aging like volume loss.

When the fat is further filtered and refined, it becomes “nanofat” that can rejuvenate thin, crepey skin or fill in tear troughs and under-eye hollows.

Fat is one of the best sources of stem cells, so autologous (“from the same person”) fat transfer can also provide additional facial rejuvenation and anti-aging benefits, thanks to its growth factors and their ability to stimulate collagen growth beyond the area where fat is transferred.

https://www.realself.com/surgical/facial-fat-transfer

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One criticism of his website that I have (and have made directly to Bryan Johnson and Oliver Zolman, but not had a response but I made the point today so perhaps some patience is warranted) is that they don’t quote the units used.

If we take hsCRP 0.46mg/dL is 4.6mg/L. It is difficult to tell from that what units they are using. The normal range people use under 0.5 or 5 (depending upon whether it is per litre or per decilitre). They say optimal is under 0.55 which might imply they are using decilitres.

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What is the monitor measuring?