Watermelon is a good source of citrulline (and lycopene). That’s why I eat a cup of it every morning with breakfast. Citrulline is also frequently included in pre workout supplements.

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LOL, good snark, JL, keeps me on my toes! But in this particular case, the explanation is remarkably simple. That which is more important is the thing that appeared first in evolution, and has been preserved in each and every single case of a nasal passage occurance. Pretty obvious really. In each and every instance of nasal passages, we have a sense of smell. From the earliest examples. That is not true for many of the other functions, such as connected to lungs, since nasal passages exist even when there are no lungs present - such as in fish. Which I already highlighted, thus showing my work. That said, you are absolutely right, in different animals, the different functions of nasal passages are emphasized, possibly even surpassing the sense of smell(?). Thus in human beings, maybe other functions are more important than the sense of smell - I don’t know, though the sense of smell seems key even here, as the paper below states. But that wasn’t my point. My point was strictly focused on evolution - the claim that the nose evolution preserved those other functions preferetially - that obviously is not the case, as the most important function evolutionarily has been the sense of smell, as I showed above (being first, and present always).

Here is an interesting paper looking at the interplay of these very issues, and the olfactory aspect even in the human nose looks pretty robust, so my confidence in this is boosted (not that I have a deficit of self-confidence, as you note, lol):

https://journals.biologists.com/jeb/article/222/Suppl_1/jeb186924/2802/The-navigational-nose-a-new-hypothesis-for-the

Quote:

" If nose shape is under positive selection, then, barring the hypothesis of Dr Pangloss that the human nose evolved to hold up spectacles (Gould and Lewontin, 1979), we must consider the hypothesis that it could function in olfaction. Subtle changes in nasal anatomy can be associated with significant differences in olfactory function (Zhao, 2004). For example, the shape of the tissue immediately past the nostrils (i.e. nasal vestibule) can have a significant effect on the flow of air to the olfactory epithelium (Zhao and Jiang, 2014). There are large individual differences in this area, with some individuals showing a distinctive notch (Ramprasad and Frank-Ito, 2016). Because the perception of intensity for soluble odorants increases when airflow is lower (Sobel et al., 1999), Li et al. (2018) hypothesized that the notch would produce a vortex that would increase sensitivity to more soluble odors, which their results confirmed. Moreover, narrower noses had larger notches, more intense vortices and higher sensitivity to soluble odorants (Li et al., 2018). Thus, there may be local turbulence in specific regions in the nasal chamber that can influence olfactory as well as respiratory function (Zhao and Jiang, 2014).

An olfactory hypothesis

If structure influences sensory function, then this structure may be adapted to a specific use. In humans, the shape of the external ear can be predicted from the statistics of the auditory landscape (Parise et al., 2014). The relative size of the eye in birds and mammals scales with the speed of movement (Heard-Booth and Kirk, 2012). If human nose shape has an olfactory function, it may have been similarly shaped by its olfactory landscape.

One reason why there should be a relationship between olfaction, nose morphology and climate is that the conditions supporting olfaction are also climactic. Odorants may become easier to detect with increased absolute humidity because water molecules compete with odorant molecules for substrate positions (Igue et al., 1972; Vander Wall, 2003), although the exact relationship between humidity and the behavior of molecules can vary in complex ways (Emanuelsson et al., 2013). Laboratory studies of olfactory threshold in humans confirm that odors are easier to detect in conditions of higher humidity and temperature and lower barometric pressure (Kuehn et al., 2008). Thus, one might predict that using olfaction would be favored in hot, humid climates but not in climates that are cold, dry or found at high altitude. In fact, there is a positive association between nasal breadth and absolute humidity (Zaidi et al., 2017; Maddux et al., 2016).

The observation that nasal breadth associates with a climate conducive to olfaction may be a clue to an olfactory function for the human external nose: the use of odors in spatial orientation. The reason is that the use of olfaction in orientation makes specific demands on the external morphology of the olfactory sensors. This is because olfactory navigation is enhanced by using stereo olfaction, where paired olfactory sensors (antennae, nares) that can compare independent samples increase the accuracy of orientation to an odor source, as I will review below. Perhaps the evolution of the external pyramid in Homo is an adaptation for spatial olfaction and hence is another contribution to the integrated suite of adaptations for efficient long-distance travel that has been characteristic of the genus since Homo erectus."

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There is no doubt sense of smell is important. The decline in brain function with age accelerates with a loss of smell sense, and can be recovered somewhat with the use of scents to exercise the brain. Scent is tied into memory like music. I find music is the easiest way to time travel…but scent is like that also. Grandma’s perfume, a pine scented Christmas tree (from a can for the artificial tree people), the smell of lit birthday candles, baby breath, a new car smell, the alcohol wipe before the needle, the expensive whiskey.

Time to play my favorite hits of the 70’s on Spotify….to be a teenager again.

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Yeah, loss of sense of smell is scary, often presaging dementia AD and all sorts of morbidities. I didn’t know you could exercise the sense of smell though, that’s wild! It’s interesting how the loss or impairments of the senses are tied to neurological pathologies. Loss of hearing and impairments of vision are also correlated with dementia. Understandable, as the brain areas that correspond to the various senses deteriorate and are a canary in the coal mine. In general, the senses dull with age, like famously, people tend to oversalt their food as they grow old, because they need stronger taste signals, the sense of taste deteriorates. Balance, coordination, you could go down the list. The brain just keeps trying to adjust, compensating, shifting areas, but at some point, there is just no more spare capacity left. This is one reason why maintaining brain health is so important, preserving spare capacity. Blood flow to the brain is super important, and exercise greatly enhances that. Nutrients need to reach, waste needs to be removed. There are so many metabolites in the brain tissue that are poorly characterized, avoiding neurotoxins - with age it gets harder as the blood brain barrier weakens. And the brain is all you have, totally irreplaceable, you can swap organs, and if your body is in poor shape, you can still keep on going, but once your brain deteriorates, it’s game over. Take care of your senses - I have many posts here about vision protection, nutrition, lutein etc. - as when these go downhill, so does your brain. That’s my holiday message😁.

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I would love to try BPC 157 but do not know where to get it.

I’ve looked through the forums and found a lot of discussion around improving nitric oxide production via various supplements like citrulline, beetroot, to name a couple. Has anyone tried prescription medications? Ie Nitroglycerin (short/fast-acting) or Isosorbide Mononitrate/Isosorbide Dinitrate (long acting). Given this forum’s general propensity for trying prescription medications, I’m surprised to see much more discussion around unregulated and largely untested OTC supplements compared to well understood medications for increasing NO.

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PDE5’s like Cialis and Viagra

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Hahaha… was my exact thinking too.

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These guys seem to have it. I’ve been going to try some also…a little hesitant to start jabbing myself. I wonder how much worse the nasal spray is. If it could help my elbows I’d probably go for it.

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I’ve become hugely bullish about Sauna after the VEGF mice study.

Heat therapy promotes the expression of angiogenic regulators in human skeletal muscle

https://pmc.ncbi.nlm.nih.gov/articles/PMC5008657/

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The researchers compared the lifespans of mice living at normal atmospheric oxygen levels (about 21%) to the lifespans of mice that, at 4 weeks of age, had been moved to a living environment with a lower proportion of oxygen (11%—similar to that experienced at an altitude of 5000 meters).

They found that the mice in the oxygen-restricted environment lived about 50% longer than the mice in normal oxygen levels, with a median lifespan of 23.6 weeks compared to 15.7 weeks. The oxygen-restricted mice also had delayed onset of aging-associated neurological deficits.
Reduced Oxygen Intake Linked to Extended Lifespan - Neuroscience News

(Higher altitude living mice presumably upregulated VEGF, EPO etc)

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This might relate a tiny bit to people permanently living high above sea level.

The oxygen content in the air remains constant at approximately 21% regardless of altitude above sea level. What changes with altitude is the air pressure, which affects the amount of oxygen reaching the lungs per breath. I have listed the relative oxygen content in the air for cities located on a very high high altitude above sea level. if they were living dramatically longer than the average person in the same country, we should have known it by now.

La Rinconada, Peru (5,100 m): About 50% of the oxygen content at sea level
El Alto, Bolivia (4,000 m): About 60-65% of the oxygen content at sea level
Potosí, Bolivia (3,700 m): About 65-70% of the oxygen content at sea level
La Paz, Bolivia (3,600 m): About 68% of the oxygen content at sea level
Shigatse, China (3,800 m): About 65% of the oxygen content at sea level
Lhasa, China (3,650 m): About 67% of the oxygen content at sea level
Juliaca, Peru (3,825 m): About 65% of the oxygen content at sea level
Oruro, Bolivia (3,700 m): About 65-70% of the oxygen content at sea level
Cusco, Peru (3,400 m): About 70% of the oxygen content at sea level

It is important to note that these percentages represent the relative amount of oxygen available for the body to absorb, not the actual percentage of oxygen in the air.

"There’s also data to suggest a 20% lower mortality for people who can exercise to a certain metabolic equivalent (MET). Dr. Shapiro explained, “An activity that has a value of 4 METs means you’re exerting four times the energy than you would if you were sitting still. Living at higher elevation may promote a relatively high fitness level since 5-7 METs are required even for slow uphill walking.”

“The point being,” he said, “is that even just walking for exercise can be enough when you when you live in this area to really improve your risk of mortality.”

On the other hand, while higher altitude may be protective against development of some diseases, it could increase mortality as a disease progresses. There is higher mortality from, chronic obstructive pulmonary disease (COPD) or emphysema, lower respiratory illnesses.

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Wow! Thanks for the study. I just want to point out that those mice were aging way faster than normal. The effect will surely be there in normal mice but maybe the “50% lifespan” increase will be lower.

Those mice only lived for 15.7 weeks? That’s about 100 days. That’s a really unfortunate breed. 900 days is more typical for most experimental mice.

Here is a website selling NO supplements

Celery salt and tadalafil.{both male and female]

Will supply NO that your body uses for pennies a day.

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Interesting information. I like Dr Nathan Bryan’s approach to caring for the endothelium of the blood vessels. I am sure others here are familiar with this. Here is a good talk with Dr Perlmutter and Dr Bryan. I do also take 1/2 of one of the N1O1 lozenges a day with lots of arugula in my salad.

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I started taking Manganese about a year ago.

We take 5mg, 5 days a week and none on the weekend.

My PWV has improved and that is an indicator of arterial elasticity. And when I say “improved”, my “number” has not changed much but I’m one year older and it’s still a bit lower than it was last year. So I call that a win :slight_smile:

My BP has also dropped significantly in the past 18 months but that is most likely due to the weight loss. BP is not as good an indicator of arterial health as PWV though, it’s just the more common measurement.

Just don’t, as in DO NOT, exceed the RDA as there are risks associated with Manganese

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this was my thought exactly. I’m taking this combo now for a climbing injury and wondered if longevity might be a side effect. have there been any murine longevity studies looking at BPc 157 and TB500?

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I don’t know of any, it would be interesting to see studies like that on some of the “popular” peptides