#15

OMG @AnUser please just stop and let’s agree that we disagree on this topic. But if you want I can use your argument, statins are dirt cheap and generic, so they should have plenty access.

This is just one of the studies on centenarians and blood markers and if you check some, you will find that higher levels of cholesterol are not detrimental, sometimes they are preferable to live to really old age… I don’t know why is it so, maybe centenarians are just people who are genetically better equipped to deal with higher levels or maybe higher is better or there is some other answer for that…

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#16

It literally mentions a region in your link where 50% of countries do not have CVD drugs in pharmacies etc.
And education and doctor access is important as well.
Do you read what you link and seek to gain clarity / a world model on this topic or are you just arguing for the sake of arguing?

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#17

I don’t buy that crap. Cholesterol is not detrimental to heart health. I wouldn’t give a shit if my cholesterol was at 500 lol. It is all but debunked. my dad as mentioned had it very high, my sister also and she loves her pecorino and Manchego. LOL

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#19

No clue what you are trying to say, and no I don’t trust Russians at all, nor anyone else with a vested interest in lying and then profiting from it. As for the vax I’d have to be a moron to take it if CDC itself had it in their website initially (then removed it later) that for me and my age group the regular flu virus was about twice more lethal. I NEVER had covid, I NEVER get/got the flu (last 15 years) and that is a 100% non-issue for me. Wish everything else was as concerning to me as covid.

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#22

@kansel are you ok? Little worried.

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#23

I saw that also, that goes against a lot of things I’ve seen that iron is pro-oxidative and damages tissues… the only thing I could guess is maybe it was correlated with anemia and/or heart failure? People with heart failure have super low iron levels, and so maybe that was where the correlation could’ve come from…

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Blood markers of Centenarians
#24

The article shows that cancer is decreasing in spite of an aging population. So, there seems to be some progress there.
It also shows neurological diseases increasing. That is because of the aging population.

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#25

Possibly true, but more interestingly to me is that even fairly high iron levels had no significant effect on mortality,

#26

So far so good. Thanks for being a good Samaritan though :smile:

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#27

Agree that is strange, would think that high iron/ferritin would’ve affected mortality in a negative manner…I wonder what the UK biobank says on high iron? I may look that up when I get time soon….

#28

A new article by one of the researchers:

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#29
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#30

low glucose, uric acid, creatinine, TG, TC and HDL in a Supercentenarian

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#31

May have to do with immunity. Iron is required for immunity, which is why, the Mayo Clinic has modified its suggested donation frequency from eight to twelve weeks.

https://www.mayoclinic.org/documents/blood-donor-frequency-change-pdf/doc-20079397

  • If iron is not allowed to build up, your immunity is lower, increasing your likelihood of becoming ill

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#32

Higher iron levels increase epigenetic age.

The results of present investigation unveiled the causality of iron overload on acceleration of epigenetic clocks. Researches are warranted to illuminate the underlying mechanisms and formulate strategies for potential interventions.

#33

Did you just read the title? Did you read the conclusion at least?

Conclusions

In a nutshell, our results demonstrated the potential causal relationship of iron overload to accelerate epigenetic clocks.

Between the epigenetic predictions, and the actual age and biomarkers of the centenarians, I’d go with the actual data.

The centenarians already won the race. So reverse engineering their genetic gifts seems to me, to be the better approach.

This may be the U shaped curve again. The centenarians were tested at age 75. So, maybe, increased iron is needed beyond that age, because the killer for most seniors are infections, not effectively parried by a healthy immune system.

#34

Yes, I think the key thing is probably a U-shaped curve. " the potential causal relationship of iron overload to accelerate epigenetic clocks.
Many older people, including myself, often fight iron deficiency.

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#35

That’d be like reverse engineering the genetics of lottery winners to gain their luck. As of now we simply don’t know whether they reached 100 due to sheer luck or other cofounding factors.

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#36

I just wanted to get this thread back on the main findings of the study, because im really interested in the findings you’ve highlighted.

Uric acid was the biggest association. Do we know what the mechanism of association would be. And how we might go about lowering it if were causative?

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#37

Uric acid. Think “gout”

Dr Rick Johnson (kidney doc) says:
Avoid high sugar, especially sugary drinks
Avoid alcohol, especially beer
Avoid purines (shellfish, sardines, gravy, etc)
Take 500mg vit C everyday
Avoid dehydration
Take SLGT2 inhibitors

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