I’m on both finasteride (1mg daily)and DUTASTERIDE (0.5 mg bi weekly) and I believe it’s the best decision i made for my skin hair prostate brain and heart health I’m 29 and people mistaken me for 24/25 always.
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Which email newsletter - source please?
AnUser
#23
Michael Lustgarten believes that youthful hormone levels might be keeping youthful appearance in check. Since finasteride affects DHT this might be the case.
Low DHT levels seems youthful?
Women also have low DHT levels, and finasteride prevents prostate cancer and DHT-related hair loss. It seems good.
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AnUser
#24
This came to mind:
A circle of eunuch men watching over a computer, channeling something, they are digital beings, no reproduction, only memetic reproduction.
DHT is higher in older men? Isn’t DHT like the active form of T?
is DHT important for muscle growth?
AnUser
#26
It seems to be stable from 20 yrs old and forward, this was in Czech men.
Both forms are active forms. Only DHT is disabled in the muscles by 3α-hydroxysteroid.
5α-Reductase inhibition does not adversely affect muscle mass | Nature Reviews Urology
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It’s interesting how DHT stays roughly constant even when testosterone levels fall with age. Doesn’t this suggest that 5ar activity increaes as one ages?
AnUser
#29
Free DHT levels peak and decline at the same time as free testosterone:
The Free DHT / Free testosterone levels are stable it seems with age.
Does that still mean there’s a difference in 5ar activity?
10.1016@j.jsbmb.2009.05.008.pdf (290.5 KB)
Does the free DHT/Testosterone graph imply higher 5ar activity in young age (low testosterone but higher DHT)?
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I once got a finasteride Rx for gender dysphoria, I should try that again (idk if new people are less liberal than old people on this)
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mccoy
#32
@AlexKChen , If I may ask, I wonder what was the nature of such pure misery?
A new dissertation on this topic:
Sex Differences in Aging and Longevity: The Impact of Castration and Potential Castration Mimetics
TYSM for this. can someone summarize the main findings?
FYI chatgpt thinks “spiro bodies” aren’t a concern (and don’t last long-term).
I have serious trauma over this but I cannot give details yet. It would do so much good for the world to resolve this, but I don’t know how yet (TMS, tFUS could help).
I don’t know what to do over this. I don’t know about transgender culture - I have some similarities, but believe more in gender-neutering than transitioning
Generally, shifting resources from reproduction to life preservation/extension seems to be a theme. Look at one of the side effects of very high dose rapamycin, testicular shrinkage and sperm production suppression. Severe CR results in the suppression of reproductive behavior, loss of menstruation etc.
Evolutionarily it makes sense. If an organism is in an environment of scarcity, it would be suboptimal to spawn the young into this circumstance.
AnUser
#37
There’s probably many clinical trials on different aspects of this, I don’t know enough about it
If the goddamn organ can be shrunk by >50%, that would do a lot alone…
mccoy
#39
OK, I missed the exact definition, I had to look it up to be sure. I also understand the neutrality = asexuality status you would like to achieve.
But I wonder, that’s a niche for endocrinologists, is it wise to mess with these subtle mechanisms on one’s own? Are you unsatisfied with the solutions proposed by specialists?
mccoy
#40
Perhaps you might develop some degree of acceptance about the physical garb you’ve been assigned at birth. Sometimes it’s better to embrace the suck, as they say in the military jargon, rather than fight it in a war of attrition that you will probably lose.
I wonder if psychopharmacological treatment would help, modulating neural networks and the flow of neurotransmitters can often achieve some results, like in depression states, stressful conditions and so on.
Also, pure mental desire or libido can be often abated by epigenetic signalings, like CR+exercise, or low-carb diet which increases SHBG.
