Because of your posts and some reading I have done, I have been taking 60 - 80mg of melatonin every day. I take 60mg before bedtime and take another 20 if I wake up during the night. Because I consume large amounts of fluids during the day this happens occasionally.
The main surprise to me is that it did not cause any daytime drowsiness. I only get blood tests 2 - 4 times a year so I don’t know yet if it will have any effect on my biomarkers.
I think the full potential of melatonin as a life-extension supplement has yet to be realized.
10 Likes
I just finished up my series of 6 plasmapheresis treatments in 3 months as part of the Lyfspan clinical study, as mentioned here: Plasmapheresis Startup Looking for Clinical Trial Participants SF Bay Area
Sadly, I’m rather conflicted about it right now… because I haven’t noticed any difference over the past few months… if anything I feel less well than I did when I was on rapamycin (I stopped prior to the trial, and have not yet started up again). I will post a longer writeup in another thread.
16 Likes
So, they haven’t told you if you were on the placebo?
2 Likes
Not yet - maybe the next time I go in…
2 Likes
If it acts to reduce senescent cell load slightly then the effects will depend upon your initial senescent cell load. CRP at the lowest level tends to indicate the level of IL-6 particularly from SASP so it gives an idea of your senescent cell load. Can you say what your CRP level is?
2 Likes
I’ve ingested c60 in olive oil before. Not the smartest thing I’ve done, eating buckyballs.
7 Likes
DMac
#13
@John_Hemming do you have any before and after data to share at all about the impacts of this protocol?
Also, where did you start in terms of dose and what led you to the point you are at now?
DMac
#14
@GoldenCB i’m interested to know your thought processes here - what made you consider doing this?
This has failed to replicate multiple times since. But man, I swear I felt something from it haha.
2 Likes
DMac
#17
@RapAdmin have your numbers changed (either good or bad) since the trial?
When you resume Rapa will you go straight to 6-8mgs or ease into it 1mg a week?
I don’t know yet - need to get a blood test next week to find out. When I relaunch rapamycin it would probably be something like a 2/4/8 mg per week ramp. After using rapamycin for 3 years, I’m really finding how that its almost like taking an aspirin - I don’t notice any effects, whatever the dose is. Anywhere from 2 to 28mg / week has no obvious effect that I can determine without a blood test. I wonder if this is a common scenario for people - a sort of “acclimatization” to rapamycin over time?
4 Likes
DMac
#19
I’m up to 8mg a week and in a similar situation in that I’ve noticed no real effects apart from in the bloods (slightly raised lipids and ALT, slightly decreased WBC)….
I’ve just booked in for Echocardiogram and CAC next week. Then bloods in another few weeks time (going to see what the addition of Acarbose has done….been taking this for a week now).
Really interested to see if there are any changes in the Echo as I had one last year (before Rapa) that showed some slight functional declines……let’s see what 6 months of Rapa has done!
3 Likes
DMac
#21
Has anyone used or have insights into:
Stem cell therapy
Exosome therapy
Peptide therapy
???
When you do blood tests what is it specifically you are measuring, testing?
I’ve tried peptides, and bio-regulators. I’ve taken BP157 and TB4 orally and injected it to try and help heal some chronic tendon injuries.
I can’t say that it made any noticeable difference at least not in the short time. Both of my injuries have healed, but it didn’t happen immediately. So it’s really hard to say whether or not it made a difference. I had long standing ankle pain from an old climbing injury and it’s completely cleared up, but again, I can’t specially attribute it to the peptides. BPC157 as an oral supplement did help my stomach. I’ve had dysbiosis since taking a couple of rounds of CIPRO a few years back, but it the relief didn’t last all that long.
TB4 is anecdotally thought to improve thymic function, however it hasn’t been substantiated. I recently read a report from a self experimenter on the Fight Aging website who found that their thymus reduced after taking it, so buyer beware.
3 Likes
I did an c60 protocoll some years ago. It really increased my phycical performane (running 5k)
1 Like
RapAdmin, did I read your post correctly, that you have taken up to 28mg of rapamycin a week with no side effects?
