#61

Anyone have opinions on weekly selegiline dosing? Since MAO-B activity takes 2 weeks to get back to baseline after a 10mg dose I don’t see the need to take it daily like you would if treating parkinson’s.

#62

Any issues with sleep taking Modafinil in the afternoon?

#63

I take 200 mg of modafinil when I get up and then I have a 100 mg at noon. I don’t have any problems sleeping. But I do have problems staying awake so I actually use modafinil as indicated. I also take a lot of tyrosine which is a dopamine Agonist so when I get up and at noon. I also take a little bit of macuna which is a faster dopamine agonist at the same times.

I have overactive MAOa Snps which breakdown dopamine is fast as I can make it. If I don’t take the agonists and modafinil, I walk around in a haze.

So the things I do to have a normal amount of neurotransmitters will probably make way too many for people with normal neurotransmitter genetics.

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#64

I take 5 mg of selegilene every morning and I’ve been doing that for over 20 years. I started taking it when it was believed to be a dopamine agonist. And I’ve continued because it’s sort of acts like a dopamine agonist as it is an antagonist for subcortical GABA. A friend gave me a popular ant-aging book about in the 90’s which got me to read the science about it.

My history of toxic exposure made me even more interested.

It protects the brain from MPTP and other neurotoxicants which damage the substantial nigra. Enough of it can destroy the substantial nigra and give you Parkinson’s overnight. Many people got exposed to it in the '80s from a bad batch of synthetic heroin.

MPTP can also take out the substantiania nigra gradually gradually from pesticides. It is a byproduct of the manufacturing and considered an ingredient. I don’t know if the government has forced the pharmaceutical companies to remove that or not. There’s an interesting documentary on NOVA from the '80s called The Case of the Frozen addict that helped us learn a lot about the relationship between neurotoxicants and the substantial nigra Parkinson’s and dopamine.

An interesting review
https://sci-hub.se/10.1038/mp.2016.127

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#65

Where do you get it from. Do you have a prescription?

#66

How did you find out? What dna analysis tool did you use?

#67

No sleep problems. 200 mg very earlynmorning an 100 mg at noon. Bed time around 9:00 Pm

#68

I have a prescription. My primary care provider is a goddess.

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#69

I used 23andme raw data. I have used GeneticGenie, Nutrahack, and Promethiease. 23andme analyzies about 15% of the genome. have an Dante labs kit that does 100% I will send back soon.

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#70

I take 5mg every other day as it removes anxiety and depression somewhat - enough to lift low grade sadness.

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#71

Just a reminder about dosage as discussed earlier:

The Life Extension Foundation (LEF) recommends daily dosing totaling 10 mg per week.

Researcher Joseph Knoll recommended 1 mg per day.

This is for Deprenyl that is swallowed and not taken sublingually.

Deprenyl was found to work synergistically with Polyscias Fruticosa in mice and rats to extend lifespan. Polyscias fruticosa is available as loose leaf tea.

I remove larger stem pieces and then pack one of these tea infusers.

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#72

Joseph Knoll is the doctor who created Deprenyl/Selegiline in the 1960s,

If you did not see in the other thread, or at the very top area of this thread.

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#73

Could you share a list of SNP ids that you think are important to check?

#74

First, like rapamycin for longevity, neutrigenomics is also relatively new and still at the pre-scientific stage.

I’m returning to this thread after some time. I was asked where I found out about the SNPs. I got them from re-analysis of 23andMe raw data. 23andMe only analyzes about 15% of the genome so I wouldn’t recommend them. I’ve got a kit ordered from Dante. Periodically they have a $199 full genome analysis sales.

With the full genome, there will be a lot of problematic SNPs. The re-analysis programs will alert you to problem mutations.

Promethiase should have all the problematic mutations. I’m going to say mutations because my Android dictation does better with that word then using the acronym. It seems to be compiled for professionals so it can go into more detail than then I can understand. On the other hand, it won’t go into enough detail for us to understand if we’re not well educated in molecular biology. And maybe evolutionary biology too.

A previous post listed the reanalysis services that I used.

I found this website when we got started 10 or 12 years ago. It’s a great overview and it’s been extended quite a bit since last time I looked at it. It is from a for-profit medical practice so you’re not going to get the best deal on supplements from them. That said, they’ve been doing neutrogenomics for a long time and might be helpful.

There is a big learning curve, even for a professionals, so if you can find somebody with a lot of experience and you have money, it might be faster to work with a person like that then hacking it yourself. The hacking is fun but it can be slow and there may be some uncomfortable mistakes. It might depend upon how young you are and how much time you have.

https://heartfixer.com/AMRI-Nutrigenomics.htm

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#75

I started selegiline June '23 at 1.25mg in the morning and ran out in April '24. While taking it I found more “clarity” of thought and more motivation. Re-ordered and started back at the same dose this week.

Have already noticed the motivation aspect has returned, pretty happy with that :slight_smile:

Our youngest son is 40 and was diagnosed with ADHD when he was 13. The Psychologist said it was “too late” to do much as he had already “adapted”. Quit school at 16, got a good union job in construction and bought his first house at 19. Then got lost/obsessed with an online game and quit work, eventually had to sell his house. He has struggled with a variety of interpersonal issues and could not hold down a job for very long. Smarter than the average bear, memory like a steel trap, incredibly ambitious, one of the hardest working men I’ve met, at least physically. Organized? not a chance but oddly, always finds the most efficient way to do what he needs to do. Authority? not into being told what to do LoL! and thus the job issues. May '22 he started his own junk removal and metal recycling business. And it’s going very well, getting lots of commercial business and enjoying being his own boss. Gets up at 4am to work out and then out making it happen by 5:30am. He’s a monster physically and loving all the peptides LoL!

He started on selegiline at 2.5mg in the morning the same time I did and ran out the same time and started back the same time. Last year, about 3 months in we were all out for dinner with some friends and without prompting he started talking about how much better he felt and how he was more able to organize his thoughts. He attributed this to the selegiline.

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#76

I ask Liner AI if Selegiline increases lifespan. Here was the answer.

The effects of low-dose selegiline on lifespan have been explored in various studies, indicating potential benefits in longevity.

Background on Selegiline

Selegiline, also known as (-)-deprenyl, is primarily recognized as a monoamine oxidase-B (MAO-B) inhibitor that is used in the treatment of Parkinson’s disease. Its mechanism relates to the enhancement of dopaminergic activity, which has sparked interest in its potential effects on aging and longevity .

Longevity Studies in Animals

Experiments have demonstrated that low doses of selegiline can lead to increased lifespan in certain animal models. A significant study published in 1988 reported that rats treated with MAO-B inhibitory doses of (-)-deprenyl lived significantly longer than their saline-treated counterparts . This finding has been corroborated by various subsequent studies, which consistently indicate a lifespan-extending effect.

Mechanism of Action

The proposed mechanism for the lifespan-extending effects of selegiline involves enhancing catecholaminergic activity. Research has shown that selegiline’s effects are dose-dependent, exhibiting both “specific” and “non-specific” enhancer effects at different dosages . The enhancement in learning ability in aged rats treated with low doses corroborates the notion that selegiline may positively influence age-related decline .

Comparative Potency

In comparative studies, it has been found that other enhancer substances, such as BPAP, may be more potent than selegiline in extending lifespan. Specifically, BPAP in lower doses achieved significant results in promoting longevity, suggesting that while selegiline has positive effects, its efficacy may not be as pronounced as that of certain newer substances .

Conclusion

The collective evidence suggests that low-dose selegiline may increase lifespan, particularly in laboratory animals, by enhancing dopaminergic function and mitigating age-related cognitive decline . However, further research is needed to explore the translation of these findings to human subjects and to fully elucidate the mechanisms involved.

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#77

Parkinson’s patients on selegiline don’t appear to live longer unfortunately. I still hope selegiline will succeed in the ITP…

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#78

So it is being tested in the ITP? I hope it does well since I’ve been taking 1.25mg for like 5 years now. The Parkinson’s patients might be using very high doses that aren’t ideal for life extension.

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#79

Yes selegiline = deprenyl: Suggestions for ITP drugs to test - #172 by LVareilles

Parkinson’s patients use 5 mg per day oral or 1.25 mg per day sublingual. So five times more than you.

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#80

lol, that was my own post from August but had forgotten all about it. Thanks

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