#21

Thank you for this topic. I have been taking 5 mg sirolimus weekly, and I thought it was a medium/low dose! Was planning on cutting down to 3 mg due to ringing-in-ears side effect, but after reading these posts, I’ll try cutting down to 2 mg first.

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#22

I have a shot glass and fill it up with EVOO. I drop the pills in the EVOO so it coats the pills and then down it.

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#23

I wrote:

You wrote:

Not sure what you’re trying to say here, but I made no argument advocating Dr. B’s beliefs. Perhaps you consider even asking the question, an argument. Was just trying to tease out what you expect to be the, presumably negative, outcome of his strategy.

Summarizer
The ad hominem appeal to authority is a logical fallacy in which a claim is asserted to be true simply because a valid authority or expert on the issue said it was true, without any other supporting evidence offered.0 It is a form of logical fallacy in which the opinion of an authority on a topic is used as evidence to support an argument. While some consider it to be a cogent form if all sides of a discussion agree on the reliability of the authority in the given context, it is a fallacy to cite the views of an authority on the discussed topic as a means of supporting an argument. The faulty appeal to authority is the opposite of the ad hominem fallacy, which endorses a claim simply based on the person making it. The intentional use of the ad hominem fallacy is a tactic used by all dictators and authoritarian leaders.2

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#24

I did explain my reasoning. I don’t think we should have too continuous an inhibition of mTOR.

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#25

Well, I just took my first dose. I dropped the pills into a shot glass of EVOO. My gosh was that disgusting!

I decided to start with 2mg. I’ll bump that up to 3 or 4mg next week. I’ll be having another knee surgery probably in 2-3 months so I’m likely going to have to pause the rapa. So I want to get going with it for a bit beforehand at least.

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#26

No, no., yes, disgusting. You don’t want a mouthful of EVOO. I am not saying that this is the best way to take rapamycin, only the way that I take it.
Get a small 2 oz paper cup or shot glass.
Put approx 1 oz water in the bottom
Put in approx 1 oz olive oil. The EVOO will float on the water.
Drop your rapamycin tablets into the EVOO all at once.
Immediately, toss the contents of the container into the back of your mouth and swallow. Follow it with a little water. Timing is important to get the rapa tablets down in one try. This works fine for me up to about 5 or 6 tablets
I take it you have never taken tequila shots You must toss it into the back of your mouth, therefore bypassing the taste buds. (Well, yeah, I am not fond of tequila and not interested in tasting it much)

image

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#27

Haha, this is essentially what I did. And I’ve had my fair share of shots (Tequila or other!). Still… pretty gross. I may look for alternatives like a high fat yogurt or something. But hey, week 1 is in the books! lol

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#28

I take a shot of EVOO every day. I don’t add the water. I guess it’s an acquired taste, as I enjoy it. However, I also add freshly ground black pepper (piperine) which helps the absorption of Rapa and NMN and cuts the taste of the EVOO. On non-dosing of Rapa days, I add turmeric (it prevents Rapa absorption). I also add 750 mg of NMN to the mixture which also adds a pleasant taste.

Also, different EVOOs have different tastes. Some are incredibly better than others. Find the one that tastes best to you (Unfortunately, for me it’s usually the most expensive)

These are the brands I use:

#29

I want to report my first 2 wks of R
I’m 77 , started with 2mg of Biocon Rapacan with a fatty breakfast , lots of EVOO on toast
no negative side effects at all , in fact very quickly the pain in a couple of arthritic fingers went away as did the mostly chronic lower back pain , in general I felt good , my daily exercise routine was solid.
I really did question whether what I felt was the placebo effect as it seemed too fast to my logical mind for R to work
Tuesday I increased to 3mg with the same breakfast …very quickly I developed a nasty clamping headache that lasted all day not debilitating but front and center till I went to bed , as well I had a general malaise with some brain fog .
wondered what I was in for the next day , well things swung back into the feeling pretty good zone , the arthritic and back pain still at bay , head clear , a good resistance session that afternoon,
yesterday was kind of neutral
today I did my weight lift routine and it was tough compared to the other day , but in general feel good
not sure whether to up another mg next week or stick to 3 …?
Many have told me that I need to get the dosage up according to my age

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#30

Hey Larry, I’m not an expert. I’ll only be on week #2 here of my rapa journey.

That said, I’d recommend sticking to 3mg this week. See if that headache flares up again or not.

I did 2mg my first week and really didn’t notice anything. I’m tempted to pop it to 4mg this next week but will probably just bring it to 3mg and see how that goes.

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#31

TBiz thanks for that good advice , stabilize at 3mg then onward …
do you enhance w anything GF etc ?
keep us posted w your experiences ,
this forum is important IMHO as we are pioneers of a sort :wink:

#32

Glad I could help. I may start a thread of my own just for m journey if it’s beneficial.

I have no done any GFJ based on comments in this thread. It seems there are too many variables to really know how much rapa absorption you’re getting with it. So I’m holding off on that for now.

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#33

right , I’m just doing the R in the morning w EVOO and toast :wink:

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