Anti-aging Benefits of Rapamycin, Personal Experiences (part 2)

[Agetron]

I think you are spot on.

At 62 years, I was already having a variety of issues… visceral fat, dysphagia, memory issues, strength diminished, loss of skin elasticity, eye issues.

These and more were greatly improved by 3 + years of rapamycin.

[Arhu]

I’m 49 and that is indeed what I voted

[RapAdmin]

I am just finishing (as a subject) the year-long PEARL clinical trial using Rapamycin, where one of the principal endpoints is visceral fat, as measured in a DXA scan. I have seen a 30% drop in total-body visceral fat, from about 3.3 lb to 2.3 lb.

Source: “TahoeDenizen” here

[Alpha]

Approximately 18 months on Rapamycin. First 3 months a 6mg once per week. Then off for some 3 months (detailed elsewhere). Then restarted at 12mg once per week.

After 3 months on following my restart, I effortlessly dropped from a peak pf 206 lbs / 24% body fat to 194 lbs / 21% bf.

About six week ago I started another loss of weight. Note: I had upped my physical activity quite at bit.

This morning I weighed in at 177 lbs / 17% body fat.

Blood work great. Interesting journey.

[RapAdmin]

Immune system age after 9 months using Rapa: -17 years (from -10)

I wanted to measure if rapa was useful for my N of 1 and it does! I took a TruDiagnostic test in February before stating rapa and another one in November. Before rapa my immune system age was 10 years younger than the chronological age. Now, after 9 months of 6mg weekly rapamycin it’s 17 years younger. I didn’t really change anything else during that period except I added acarbose (50mg/meal) a few months ago. My glucose is still too high though. My DunedinPACE of aging was 0.84 and is now 0.769. As a reference Brian Johnson current score is 0.69 which is better but I’m sure my slow_aging/cost ratio is incredibly better. Basically almost all the markers have improved even though I’m 9 months older. [image]

[RapAdmin]

Newly posted:

Reverse Gray Hair, Hair Repigmentation

I got my first grey hair at age 19 and by 27 I was mostly grey. At 35, there was not a black hair to be found on the top of my head. I started taking rapamycin for four months ago (age 67) and much to my surprise, after six weeks, I noticed a few black hairs sprouting. Now, it is more than a few! I might have to dye my hair white soon- what’s a guy to do? [NewBlackHairs]

[Agetron]

Exactly. New growth comes in solid black… lol.

[RapAdmin]

another benefit:

Treating Arthritis with Rapamycin-Releasing Nanoparticles

I needed no nano particles. Rapa cleared up my arthritic rt. hip. No longer painful, Have no arthritis anywhere in my body at 77 yo.

[RapAdmin]

Another possible benefit:

Cataracts Gone after a Few Months on Rapamycin

My wife’s previous visit to her eye doctor told her that she would probably have her cataracts done in a couple plus years. Her last visit she was told that there were no sigh of cataracts. She has been on rapa for about 3 months. Could be the rapa or I don’t know.

[RapAdmin]

another potential benefit:

Here’s where it gets really interesting again! My partner dipped into menopause and then rocketed back out!

Source:

My DOG, My PARTNER, and ME: A Week by Week Rapalogue

Month 14 - Rapamycin Hello again! When I started this journey I read several other people’s write-ups about their experience with Rapamycin. In every case I was disappointed when the narrative just stopped. “What happened next?” I wanted to know. Did you die?? Did you transfigure?? Were you in the ER for three weeks or had you moved to Fiji to live your best life? So I started this rapalogue mostly for the sake of others who might be interested in beginning a similar journey. At the time I made three implicit promises: 1) I would always be honest, although to be fair I have a strong emotional desire for rapamycin to work well. 2) I would keep writing so the narrative would not fall off. 2) I would only write when there was something interesting to say. So here we are in Month 14 and I have some hopefully interesting updates! My Rapa Experience So Far When I started up rapa again in the late summer/ early fall, I determined to run the marathon and not the sprint. Yes, I went whole …

[RapAdmin]

Possible nose, skin, facial benefits from rapamycin in this thread:

Can rapamycin improve sinus tissue and nose health in the elderly?

@desertshores made a reply about a year and a half ago on “The Age of Adaline” post that had me thinking… will my nose and ears look bigger as I age??? WebMD: Noses and ears are made of cartilage, a flexible tissue that’s harder than skin but softer than bone. It wears down over time and doesn’t give as much support to the skin on top of it. Your skin also loses elasticity and firmness over time, and it tends to sag. Loose or [sagging skin].(Healthy Beauty: Skin, Hair, Nails, Anti-Aging, and Cosmetic Surgery Tips) over a weaker cartilage frame makes ears and noses look longer. I have been noticing facial changes with the rapamycin (now 3.5 years of weekly use no breaks) and my face is not getting more saggy (actually fuller - just as the “crepey skin” has gone away, on arms and neck. My eyesight is better, hearing is better and my dentists (two) say my gums and teeth are incredible at my age - no periodontal issues. My sinus seems to be rejuvenating or repairing at least. My nose i…

[hitch]

Rapamycin and Periodontal Disease

I went to the dentist for a cleaning yesterday. For several years, I’ve had inflamed gums- based on measurments taken by the hygenist. I have used a waterpik and Sonicare toothbrush for many years, but no improvement.

I have now been on rapamycin for seven months and have read the mouse studies that show rapamycin combats periodontal disease. I had high hopes/expectations that I would show significant improvement. And rapamycin delivered!

On average, the teeth where the gums had shown the most inflammation had an average improvement near 40%. Happy about that!!!

[hitch]

Rapamycin and Prostate Health

I’m 68 and I retired six years ago. I remember a few “aging” conversations I had with some work buddies while standing around the shuffleboard table. They were all much younger than me- 30’s to early forties. I specifically recall telling then about how my “stream” was weakening (not that they were really interested, but I always liked to share).

More recently, about two years ago, I started to get sudden urges where I had to immediately head to the bathroom. I felt I’d pee my pants if I didn’t hurry.

Both of these (weaker stream and sudden urges) are hallmarks of aging.
Your prostrate grows larger as you age, resulting in a narrowing of the space for your urethra.

After seven months on rapa, I can’t say I’m peeing like a horse as I’m not really endowed as such. But, the strong stream has returned!! My wife even commented on it from the other room. And I almost never get the strong urge anymore.

This is certainly an N=1 with no data to back it up. Has my prostate grown smaller? Maybe it’s an anti-inflammatory thing? I don’t know…

[DrT]

These experiences are interesting to read, but I would urge contributors to also include the dose and timing of your rapamycin, please.

[hitch]

I take 8mg (Biocon Rapacan from Shreeji/Impex @ .60 per mg) every Friday morning on an empty stomach.
I’m 6’1 and 210 lbs.

[Virilius]

The only pathway I can think of is rapamycin somehow lowering your testosterone which also lead to less 5ar activity in your prostate, resulting in your prostate shrinking.

[L_H]

This looks interesting

Rapamycin and Low-dose IL-2 Mediate an Immunosuppressive Microenvironment to...

[Goran]

This is great information for us with BPH

[ng0rge]

The linked study says that Rapamycin stops the progression of BPH but doesn’t shrink the prostate. From other threads here I thought that Rapamycin doesn’t decrease testosterone levels. However there were reports that Rapamycin reduced the need to get up and pee during the night (in men). Should prostate enlargement be include as a biomarker of aging? (50-80% of men over 50)