#31

Think there seem to be a lot going for that best in class probiotics (like eg Pendulum) seem to be achieving that too. (Better gut lining, more butyrate, digestive health in addition to all the glucose spike modulation and average glucose/HbA1c lowering).

2 Likes
#32

Haven’t listed to it yet, but this seems to have a load of valuable context:

In this episode, Colleen delves into the complexity of the microbiome, how it is tested, and how it changes over time. She explores how probiotics, prebiotics, and postbiotics affect the gut and makes a compelling case that well-developed products have the potential not only to enhance gut health but also to positively influence overall metabolic well-being. Colleen emphasizes the significance of a high-fiber diet in sustaining a thriving gut microbiome, shares insights on minimizing microbiome damage during antibiotic use, provides tips for fostering and preserving a healthy gut, and much more.

More detail with time stamps
• Colleen’s background and current focus [4:15];
• The basics of the microbiome [6:45];
• The study of the human microbiome [14:45];
• Categories of bacteria, and the implications on health of the rapid evolution of bacteria [19:15];
• Methods for measuring and understanding the microbiome, and key indicators of microbiome health [28:00];
• The important role of fiber for promoting gut health through the production of butyrate [38:00];
• The case for manipulating gut bacteria via fecal microbiota transplant (FMT) [44:30];
• Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome’s diversity and function [49:45];
• Factors that influence the vaginal microbiome [54:45];
• The effect of gut microbes on obesity and challenges with fecal transplants in people [58:15];
• Beneficial strains of gut bacteria and strains commonly found in probiotics [1:00:45];
• The difference between a probiotic and prebiotic, and how CFUs are a measure of the “active ingredient” [1:09:15];
• Considerations about how probiotic strains are produced, and more on the meaning of CFU [1:13:45];
• Mitigating the effect of antibiotics on the microbiome [1:22:00];
• What do we know about the effect of artificial sweeteners on the gut microbiome? [1:29:30];
• Why Akkermansia is a keystone strain with implications for metabolic health and an individual’s response to dietary interventions [1:35:45];
• The essential steps necessary to develop a robust probiotic for optimal health support [1:45:15];
• How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more [1:48:15];
• Pendulum Therapeutics’ commitment to rigorous product develop [2:06:00];
• Details about the probiotic “Glucose Control” and other probiotics developed by Pendulum Therapeutics [2:12:30];
• Further studies of Akkermansia that have been proposed or are underway [2:20:00]; and
• More.

2 Likes
#33

Taking acarbose, I believe Pendulum on top of this would be overkill sice they seem to have similar effects.

#34

I’ve heard that Acar is may be good for microbiome beyond smoothing out the sugars, but don’t know in what specific ways that is/is supposed to be the case - do you know the specific ways?

#35

I recall an increase in beneficial short-chain fatty acids. Probably more details in the lengthy thread on acarbose.

1 Like
#36

@Ulf The information on adding vinegar to reduce AGEs came from my podcast with the leaders of the Anti-AGEs Foundation

Here’s the thread in this forum with link to episode.

Here are some papers that are interesting. One is a review of fruit vinegars but not balsamic (grape). It is clear from the papers that cooking with vinegar reduces formation of AGEs. Adding vinegar to already cooked food may not have the same effect (cannot find a source), but is mentioned in the fruit vinegar paper as a way to gain certain phytonutrients that inhibit AGEs absorption.

https://www.sciencedirect.com/science/article/pii/S0925443918303296

4 Likes
#37

https://www.sciencedirect.com/science/article/pii/S0753332221003802#:~:text=Berberine%20is%20a%20potent%20prebiotic,mucin%20secretion%20in%20host%20intestine.

This paper says to take berberine to boost akkermansia in the gut. I have already been using berberine. My experience with akkermansia has been good. The next question is will the akkermansia stay in my gut after I stop supplementing…which I will do.

2 Likes
#39

Nearly all probiotics are unlikely to establish a permanent presence in the gut. You can check out reviews of Pendulum’s Akk probiotic on Reddit, where many users have reported testing Akk for three months with no detectable changes

2 Likes
#40

@sml491010 Yes but as a counterpoint, if you look at the rapamycin surveys you see that most people don’t notice any benefit from rapamycin. Does it not do anything good? I don’t know for certain but I think rapa has helped me in several ways.

Akkermansia has certainly been doing something to me. We’ll see if it is overall good and if it lasts.

I am willing to gamble on good bets. I just try to avoid big risks (big downside: injections, messing with hormones, chronic antibiotics, cancer meds, etc), too many simultaneous bets (10 chemicals a week is my limit), and wasting money for too long on poor bets (no way to tell if it helped) and unnecessary supplements (get in food). And I always use blood and physical biomarkers to monitor what is happening.

4 Likes
#41

Additional benefits of rhubarb.

Table 2, page 2

Results: The mean systolic blood pressure and diastolic blood pressure in the rhubarb group before and after the intervention were 144.87 ± 8.73 and 95.75 ± 7.72, respectively, after intervention, to 133.95 ± 10.98 and 83.73 ± 25.28% decrease. Paired t-test and Wilcoxon showed a significant decrease in systolic and diastolic blood pressure and diastolic blood pressure with rhubarb intervention (p <0.05), but no significant changes were observed in intervention and weight oss control groups (p <0.05).

FBS (fasting blood sugar?) 288 to 226
HBA1C 9 to 7 [page 2, table 2]

Sample population was 80 individuals, randomly assigned to rhubarb versus placebo.
Dosage was 400 mg rhubarb extract 3x/day

2 Likes
#42

What has the experience been?

1 Like
#43

For unknown reasons, I started experiencing stomach upset when I ate dinner (gas, bloating). I eat a high fiber diet but hadn’t changed anything so I was waiting it out. And waiting. I started on akkermansia. At first I had loose bowels but on day 2 settled down. After a few days I was back to normal but with better, faster transit time and zero constipation (I have had a tendency to it forever). If I can keep this state without supplementation I will be happy.

4 Likes
#44

I bought two bottles on iherb, i dont se why this one wont colonise the gut since it eats and renevs gutmucus and lives in it… unless you go on another antibiotic cure it should have all the feed it wants to reproduce and continue life etc

3 Likes
#45

Sorry, which product is this if my ask, sorry if I missed it.

#46

Not sure if links are allowed, this one i ordered: https://www.iherb.com/pal/referral/pdp/JOX200?productId=124047&rcode=JOX200&utm_medium=appshare . Bit pricy, but curiosity got to me :sweat_smile:

2 Likes
#47

If I were to try Akkermansia, that’s the product I would try. Let us know how well it works! :slight_smile:

2 Likes
#48

Well, I decided to buy some Akkermansia from Pendulum on iHerb. I also bought the polyphenol booster. @约瑟夫_拉维尔 Are you supposed to take this with a meal, after a meal, before a meal or on an empty stomach? Just trying to give these little guys the best chance I can. :slight_smile:

1 Like
#49

You can find out your akkermansia level, relative to a healthy adult population, as a line item in a Thorne gut health report.

akker
akker1235×597 27.2 KB

The two red dots are at 8%, and then 14%, three months later. Was targeting other things during that period.

I’m one month into a three month trial of Glucose Control. Will do another Thorne report at the end of March and see what changed.

6 Likes
#50

@DeStrider I take with my breakfast of steelcut oatmeal, wheat bran, and berries to provide food for the bugs. I am only doing Akkermansia for 3 months…I hope it takes. I eat about 50g of fiber a day from 30 different plants a week (fiber and phytonutrients) so I am providing as welcoming an environment as possible.

2 Likes
#51

My pendulum Akkermansia arrived today. I bought the polyphenol booster. I’ll try it for a month. I’m hoping to see some weight loss before I buy another month.

3 Likes