#403

The gastro issues might signal efficacy if the gut microbiome is involved in as per the 2020 Michael Lustgarten video above. Of course it’s not worth it if someone gets that side effect, just saying it works in general. It makes me question if blood glucose reduction is involved at all, but there is that diabetes drug canagliflozin that works on that, which does improve lifespan?

#404

Are you talking about the Monch Monch or the Pendulum?

Pendulum did at least one a real clinical trial that seemed legit.

Have a vague memory that they might have done a trial for the Monch Monch too, but haven’t seen.

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#405

All probiotics, in general. See the video of increasing death and the funnel plot showing publication bias.

#406

Ok, thx for color. (Note that Monch Monch is not a probiotic if I understand it correctly)

#407

Perhaps, and any noxious fumes we create while on acarbose … we can tell our family members that its helping Them live longer (humor):

5 Likes
#408

Very interesting. I think it goes on to show that introduction of adversity (in many forms, but this case in harmful gases) activates our own protective mechanisms, which in return translates in healthier and longer lives. That’s why I try to do the following as often as i can:

  1. fasting
  2. cold showers
  3. heavy lifting
  4. 100-200 yard sprints (running as fast as i can)
  5. yoga (but need it more often)
    As far as adverse smell haven’t decided on it yet, but most likely will not try lol
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#409

It’s a joke that Pendulum’s Akkermansia doesn’t settle in the gut at all.

#410

I haven’t tried the product yet. There’s too much hype on probiotics these days. I’m sure the right one will help, but which is right?

#411

I believe the only thing you can try is Florastor, a type of Saccharomyces boulardii yeast. Additionally, you can supplement with Butyricoccus to increase short-chain fatty acids in the gut, such as butyric acid, which can help reduce intestinal permeability

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#412

Seems to also be an area where the world’s knowledge base really has and is developing a lot.

Was just seeing this yesterday that was interesting in The Lancet. Ht Eric Topol.

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Quite impressive:

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https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00685-0/fulltext?utm_source=substack&utm_medium=email

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#413

Amazing. I’m also struck by the incredible placebo effect or perhaps regression to mean.

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#414

Yeah, but part of probably that in 6 months the body does to some meaningful extent heal and improve key things on its own.

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#415

Right. “Regression to mean” covers a lot of ground. No doubt some placebo effect as well since it is everywhere.

I wonder if the placebo effect is an unconscious mechanism of the body to heal itself or if it is a lowering of the body’s sensitivity to the symptoms of the disfunction/ illness. Or something else entirely…

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#416

Great point, can’t trust this study. 6 months for a disease that would most likely be cured on it own in such period (by our immune system). Meaningless to me. Had they said in one month that would have been something.

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#417

Study seems legit. In a top journal. Clearly many people across dozens of other credible studies have problems after more than six months.

#418

Hong Kong studies are usually legit. It’s not like the rest of China.

That being said, it’s true that some people probably healed with time.

#419

I am not questioning the study itself. I’m sure it is legit, but I’m questioning validity of the finding. 6 months is a bit too long of a period and the results could as have been as result other drivers (ie immune system) in other words the premise may be a bit flawed not necessarily the study itself.

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#420

What dose of Acarbose is everyone taking? I’m on 50mg morning and 50mg evening with meals. Sometimes I’ll take more if I have a heavy carb meal in the afternoon.

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#421

I’m taking 25 mg once a day from time to time if I have a meal with a lot of grains or pasta.

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#422

Yes, I wait until I’m having a meal with some carbs and I take 100. Sometimes it’s only once a week…

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