Do you mind clarifying what you mean by ‘I am chunky’ despite doing regular exercise? Are you saying taking rapamycin has brought this on? Also how much Rapamycin are you taking weekly and why not take Berberine on the days your not taking Rap?
1 Like
I haven’t taken the plunge yet, so my suggestion doesn’t come from experience.
You said earlier you would start with 1mg and work up to 5mg. Couldn’t you just lower the dose and retest later?
AnUser
#23
Total cholesterol is not a good biomarker. You’d want either the non-HDL-c by substracting HDL from it, LDL, or for the best measurement apoB.
umi
#24
I take it once a week, at 6mg. The only reason I do it this way is from reading a lot on this website. How do you mean intermittent? Less frequently? More breaks? Thanks 
umi
#25
@Kidalondon No Rapamycin definitely did not bring this on. I’m a 61 year old woman, I’d say abdominal fat came on very slowly during peri and post menopause. I weigh 172 ish pounds, height 5’4". To be fair to myself, weightlifting has given me a fair bit of muscle, so not all of this weight is fat. I can still deadlift around 180 - though I should do more, I’m lifting more cautiously now because my knees are not great. I also row on an erg a couple of times a week, and swim regularly in the winter.
Yes, I’m back on the Berberine as of yesterday - I wondered if it was in fact the Berberine that brought it down in the first place, so I stopped for two months to see.
Also I’ve been off Rapamycin for around a month because I was sick, now I don’t know what to do… How long does it take for Rapamycin to elevate the lipid profile, and how long does it stay elevated? Does anyone know?
@AnUser LDL up from around 134 to 155.
1 Like
umi
#26
@mondagai I could, it’s all pretty confusing as we all know - hard to know what to do.
nikney
#27
Berberine and astaxanthin are on my longevity plan once or twice a week and they are two great supplements. Berberine is an AMP activator like metformin. Astaxanthin is a great free radical scavenger. Why are you so negative about it?
umi
#28
@nikney I’m not negative, and I take both of those again as of yesterday. I upped the cardio and at the same time I started berberine and bergamot, and I wanted to know if the big drop in the lipid numbers were due to supplements or cardio or both, so I stopped the supplements, and the numbers jumped up. I had some fantasy that cardio alone would be enough Supplements=$€, cardio is free, that’s all. Back to supplements 
1 Like
L_H
#29
Interested to hear what happens to your ldl-c now you’re back on the berberine. Please keep us updated
And good luck!
2 Likes
