#21

Mg supplements will bring it up… it is dose and formulation. Irrespective, these drugs (PPIs) are harmful, and wildly overused. Never indicated, beyond 4 weeks.
Mess up B12 and endogenous NO, increase risk of dementia and osteoporosis.
Not on my list of things to take unless I’m trying to expedite my wife collecting on my life insurance!
In regard to the clomid, monitor, you are in the minority in your age group that this works for, but this is superior for several reasons when it works over giving testosterone.

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#22

( dose and formulation). I did not get into the normal range on supplements. Close but not normal. Initially I was told to use oxide which is the cheapest but it didn’t budge my numbers. I then tried a few different types as I found that most have lousy uptake. (You may make take 1000mg but only uptake 10mg). I ended up using a combo that had magnesium glycinate, magnesium malate, magnesium taurate & magnesium citrate for uptake and bioavailability. This was the one that brought it close to normal. But it was expensive so I ended up quiting the PPI. (and then the Mg suppl as my Mg went into normal range after stopping PPI use.)

#23

Good thing to be off the PPI in general. As an aside, magnesium oxide has ~4% absorption … so cheap — but not a good source.

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#24

Yes. I believe the best forms of magnesium are Magnesium glycinate, threonate, or citrate depending on your needs… :wink:

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#25

I suppose but then my stomach acid wasn’t being controlled. I already had barrett’s stage 3 when I went on the PPI. I have had a number of times the past 9 months where I had food getting stuck on the way down. The last time about 3 weeks ago it hurt so bad I thought I was having a heart attack! I have an EGD this friday to see what’s up… (then my colonoscopy the following week). That’s why in an earlier Post I was asking about stopping my sirolimus dosing. My Gastro said there’s a new medicine out that shut’s down acid production like a PPI but doesn’t have the side effects. We’ll have to put in paperwork for my insurance to pay for it because it’s Non-Formulary??; (depending on what the EGD looks like.)

#26

New video here where it’s mentioned at the 25:30 mark. He says they don’t really see insulin resistance with people using 6mg per week but they do see A1C increase, which might have something to do with the red blood cells but not actual insulin resistance.

To add my personal anecdote to the pile, I was a bit alarmed to see my A1C increase to 5.4 when I have seen it as low as 4.8 in the past.

#27

Last monday i took 22mg with gfj and a bit of pomegranate. Since then the cgm charts have been really interesting. Average glucose has gone up and reading papers it appears to be hepatic insulin resistance.

At the end of july i took 16mg plus gfj. However, i was not wearing a CGM. HbA1c is vulnerable to a large number of factors.

I am expecting my insulin resistance to fade with the systemic half life of rapa. I have at least 20 more days of CGM so should be able to follow this in full.

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#28

This is something I’m very interested in hearing updates for. It doesn’t look like we have good human evidence of elevated A1C from intermittent Rapamycin so anecdotes are going to be more important here. I might take 8 weeks off Rapamycin and see if my A1C goes back down.

Another thought is how important is a few decimal points of increased A1C if it still increases lifespan? Are there good animal studies on A1C for Rapamycin use?

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#29

a) I think there is good evidence of Rapamycin causing higher glucose levels. I do have my own CGM charts for this, but I think in a broader sense there is already this data.
b) I think there is a problem with particularly high levels of glucose (over 8 mmol/l) driving higher levels of ROS which causes more damage to mtDNA (and hence a key element of aging, perhaps the key one even though senescence may be more significant.
c) Improving mitochondrial efficency is a key positive and there will be a balance between this and b).

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#30

I’ve decided to try a combo of low dose Metformin and Berberine to see if that will significantly impact my HBA1C.

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#31

I can see from my single large dose last Monday a material effect on blood glucose. I will post the charts some time over the next couple of weeks. It will take me some effort to prepare them for posting.

Sadly my blood draw for friday was cancelled, but I will have one on Tuesday and had one last Tuesday.

Because HbA1c measures over a period of time (although glycation is not irreversible as well) then I don’t know how much the values will actually shift.

There is an interesting question as to how much it matters. I think it matters where it pushes glucose over 8 mmol/l 144 mg/dl as that drives a different pathway. I wonder if it increases metabolism as well.

The last time I took a large dose I was not wearing a CGM so I only have the HbA1c measurements which I have previously posted about.

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#32

I would be thrilled to see 4.8. Mine usually is 5.4 or 5.6 and I excercise 6-7 days a week for a hr each day and watch my food intake.

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#33

My lowest was 4.18. My CGM says currently an average of 5 mmol/l which is 4.8%. About a week after my serious, but not mega, dose of Rapamycin it was about 6%, but importantly it was an increase in the base level rather tham the peaks.

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#34

Interestingly a few hours later the average has dropped to 4.8 mmol/L which equates to 4.6% HbA1c. I think my systems changed to generate more insulin after the rapamycin dose and the high insulin is still running and perhaps over reacting to glucose. This seems to be the case from the blood tests, but I still have some to go (including one today).

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#35

Hi,
it’s been awhile since i visited the website. what would I be monitoring for? (Clomi use)

#36

I’m presuming you are a male. I’d monitor FSH/LH, free testosterone, and estradiol as the primary items, and for side effects. You’d expect FSH/LH to increase. I currently prefer enclomiphene.

#37

yes, male @66 yrs old
thx.

#38

You’d expect elevation in FSH/LH which should then generate more testosterone (and as a side product estradiol) as expected effects of clomiphene/enclomiphene.

#39

I’m going to do some more reading on enclomiphene. as i suffer from depression. PTSD and anxiety it appears it might be better for me than clomi.

1 Like