That’s in mg/dL. Many tests have that as the minimum threshold. I use one lab which has a 0.016mg/dL minimum threshold.
it would be intressting to see a statisik, a table or something like that.
Maybe one can put a database online. I could do that, but I have no time at the moment.
I am working on this with my son, but we have not got there yet.
约瑟夫
#128
Would you know/could you find out what analyzer/test kit is being used?
Where do they{the lab] get there reference?
Do you have any other data sources to triangulate with those from the watch to check for accuracy? I have heard that the glucose levels are not accurate.
约瑟夫
#130
You calibrate the watch software “H Band”{the app] to a blood glucose monitor reading
You also calibrate the blood pressure portion of the software to a blood pressure monitor reading.
You are aware that “FDA” approved glucose monitor’s are + or - up to 30% and that was acceptable to approve them.
In my view for my use the watch works fine.
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One option is to use https://biomarkeroptimizers.com/ to collect biological age statistic. I created it 2 months ago with Michael Lustgarten’s input.
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Hi all. I am new to the site and just starting down the journey. Have ordered Rapa from Oddway international (super easy and convenient). I plan to start with 1 mg per week and go upto 6 mg as many have done. Before I start I decided to do a bloodtest (at Labcorp). Very convenient - I ordered the CBC and CRP test (could not find them together). The results came back today, however the CRP only says <1 - the exact value is not shared. It seems like the longevity advantage calculator is sensitive to this number. I used both .5 and .3 (default) and it gave me a lot of variation. My chrono/phone age on the first is 41/37 and on second is 35/20. Not sure how to get the lab to give me actual results. Also I’m 55, so not sure of these results as they are way off. I am uploading my test to get some suggestions or tell me what I may be doing wrong. Thanks in advance.
amitaug2023.pdf (6.1 KB)
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Two different CRP tests at labcorp, you want ‘high sensitivity’.
Don’t know how you order your tests, but it you do it through Marek Labs, they only offer the HS version.
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Different labs have different measurable minima two labs i use go down to 0.16 and 0.15. I believe labcorps minimum is 0.3 (all mg/l) watch the units some use mg/dl.
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Though my own CRP readings are always reasonably low and I continue to get them, I have yet to be convinced to put any stock in them except over a long period of time.
“As mentioned above, mild elevations in CRP can be seen without any systemic or inflammatory disease. Females and elderly patients have higher levels of CRP. Obesity, insomnia, depression, smoking, and diabetes can all contribute to mild elevations in CRP, and the results shall be interpreted with caution in individuals with these comorbidities.”
Conversely: “Certain medications, such as non-steroidal anti-inflammatory drugs
(NSAIDs), will falsely decrease CRP levels. Statins, as well, have been known to reduce CRP levels falsely.”
This would leave one to believe that you should discontinue, NSAIDS, magnesium, statins, and any other anti-inflammatory supplements that you are taking for a reasonable amount of time before testing. If you do not, how sure of the results are you?
C Reactive Protein - StatPearls - NCBI Bookshelf.
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CRP, however, is stimulated by IL-6. There are two main sources for this
a) Recent infection
b) SASP
If you track CRP over a period of time you will see it go up for periods and then come back to the base state. The base state indicates the burden of senescent cells.
Because I do weekly tests I can see this happening and link the temporary increases to infection.
It should be noted that Morgan Levine’s phenoage uses the natural logarithm of CRP to guide the calculation. That is because even at relatively low levels changes are significant for mortality (I would argue because it is linked to SASP).
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We will just have to disagree. The Aging.ai test does not use CRP in its calculations.
CRP is never a standard wellness test with any of my providers.
Also. do you stop taking NSAIDs, magnesium, and other anti-inflammatories before your tests? If not, you do not know the underlying inflammation.
I don’t like to take NSAIDs. Perhaps once this year I took some aspirin. I do take Magnesium. I also test for serum magnesium with some labs. I would not see Magnesium in the same role.
We don’t have to agree on everything anyway.
The reason I mentioned magnesium supplementation was because I have come across several mentions that supplementation reduces CRP. I have not come across any that mentions how immediate the effect is, or how long you would have to stop before taking a CRP. Since magnesium has a very long half-life it might take some time.
“The biologic half-life of Mg in the body is about 1000 hours (42 days) [11].”
Since I take magnesium in the form of magnesium glycinate, I now wonder if this invalidates my “native” (without supplementation) levels. If so, I would rather not get my CRP level checked than give up my magnesium supplement and other anti-inflammatory supplements.
Not to get too far down in the weeds in this discussion, but I think maybe I need to find out what optimal levels of magnesium are and get my magnesium levels checked. It is not included in my standard wellness tests, meaning insurance pays for it. The magnesium test from the lab I use is $19.
I take a magnesium supplement because of the constant blather: “Most people are deficient in magnesium”
“In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, , in particular, serum CRP and NO levels.”
“This meta-analysis suggests that Mg supplementation significantly reduces serum CRP level”
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zazim
#141
Before I started my rapamycin journey one year ago, I was -13 years on both of the Levine markers. Today I am -5 and -4.
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Adequate magnesium is required for the body to function well. A sign of the body not functioning well is a persistently high CRP. Hence if you are deficient taking Magnesium will constrain and possibly reduce CRP. However, that does not mean that Magnesium results in a misleading CRP.
CRP is driven by IL-6 which can be induced by prostaglandins. Cox inhibitors artificially constrain prostaglandin production. Hence taking an NSAID like Aspirin will artificially drive down CRP and arguably give a misleading result. However, I would suggest that we are looking for the CRP driven by senescence that Cyclooxegenase inhibitors have no effect on.
However, personally I don’t like COX-1 inhibitors and I am not sure about COX-2 inhibitors so that is not really an issue.
约瑟夫
#143
Was this from the paper you post?
Which lab?
Are you measuring serum level or inside{intracellular] RBC level?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637834/#:~:text=The%20biologic%20half-life%20of,42%20days)%20%5B11%5D.
“The biologic half-life of Mg in the body is about 1000 hours (42 days) [11].”
I use Quest Labs and normally get a script from Ulta Labs.
I have never had a magnesium test, but I may get one in the future for curiosity’s sake.
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