There is supposed to be 7-tablet versions available (rather than 30). I haven’t been able to find a supplier yet. This would make storage / preventing waste a little easier…
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Are his prices for real? $4us for 100x 5mg tadalafil? That’s crazy!
Yes, and on my first order from another vendor, the vendor threw in an extra 100 as a bonus.
A recent quote from Maulik:
Please find the quote as below
Tadalafil 5 mg - 15$ / 300 tablets
Dutasteride 0.5 mg - 15$ / 300 tablets
Shipping to USA - 20$
Total - 50$
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Are they legit? This price almost seems too good to be true.
They are legit. I’ve ordered from them as well a couple of times. Maulik is my source for Galantamine.
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Hell yea man. This changes everything. I made a small order to test it out.
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This earlier posted Open Access paper is now available:
The lifespan-extending MEK1 inhibitor trametinib promotes regulation of de novo lipogenesis enzymes by chaperone-mediated autophagy
In this paper we show that inhibition of the MEK/ERK cascade, by Tram, diminishes at least five enzymes involved in hepatic de novo lipogenesis (DNL), and does so via a non-transcriptional process. We show that Tram treatment enhances CMA in mouse liver and cultured cells, and that augmented CMA is sufficient to explain transcription-independent downregulation of DNL enzymes. Levels of these DNL enzymes are also downregulated in young adult mice by Aca, Cana, and the CR diet. CMA-mediated alteration in protein levels may be an important non-transcriptional regulator shared by several models of slower aging in mice, and may play a role in lifespan extension induced by Tram on its own or in combination with Rapa.
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