#62

This morning, I slept in. My cat named Caruso (because he’s vocal) started meowing right at 9AM. Why? Because he was starving—his food bowl was empty.

Ok, he really wasn’t starving but he was in a state which affected his behavior, and I think that can be the same for keto, or caloric reduction diets. One is not going to fast for a few days and poof malignant, invasive tumors *gonzo.” But still, there are tons of evidence that high blood glucose = higher morbidity and mortality. Interfere with cancer cells metabolism and things happen. Indeed, they might not “starve,” to death, but there is evidence that in some of them you may turn back on apoptosis, which the cell has stifled, it’s not death, but in that case, it’s the end of that abhorrent cell.

I’ll agree, you can remove glucose and tumors will use glutamine. Effectively remove both and you may not kill every cancer cell but you’ll have a very + effect via a very negative effect on the cancer cells.

“The press-pulse therapeutic strategy is designed to target availability of glucose and glutamine thus starving tumor cells of their most important fuels and increasing their vulnerability to oxidative stress and apoptotic death. Low-carbohydrate, high fat-ketogenic diets coupled with glycolysis inhibitors will reduce metabolic flux through the glycolytic and pentose phosphate pathways needed for synthesis of ATP, lipids, glutathione, and nucleotides. DON and other similar glutamine inhibitors will deprive proliferating tumor cells of the glutamine needed for TCA cycle anaplerosis, and synthesis of glutathione, nucleotides, and proteins.” From: Press-pulse: a novel therapeutic strategy for the metabolic management of cancer

I like this article that I think fairly looks at the concept:

How Far Are We from Prescribing Fasting as Anticancer Medicine?

#63

This is where Thomas Seyfried’s perspective of cancer being a metabolic disease (really bad mitochondria) comes in. An interesting thing to me is that there is evidence of macrophages swapping around mitochondria and that this potentially drives metastasis as the macrophages get bad mitochondria that they cannot cope with.

2 Likes
#64

Somehow doxycycline keeps the cancer from switching fuels. I don’t understand it, but the integrative guy my daughter sees has her taking it before the IV vitamin C. She has a K-RAS cancer and it is especially susceptable to vitamin C. The cancer thinks vitamin C is glucose. The molecules are similar enough. When it eats the vitamin C it dies. To keep it from switching fuels, they give the doxycycline.

2 Likes
#65

Definitely. I believe in doxy, to get all the nasties out of your system.

I take one hundred mg once a week.And have for a couple years now.

No infections or illnesses, despite regular rapamycin with no breaks.

5 Likes
#66

Two questions: Doesn’t it mess with your gut biome? And, might you, over time create resistant bugs?

3 Likes
#67

Hey Justin.
I’ve been following your challenges with prostate cancer. My thoughts are with you buddy. Looks like you’re getting good medical information to consider on the site… , it’s a difficult row to hoe. Hang in there.

I definitely find no issues with Doxycycline and my gut biome. Stool… digestion excellent.

I also take kefir pretty regularly… 1/2 mixed with milk to extend it. That helps.

Doxycycline pep is now seen as a prophylaxis for STD’s… for those not knowing. 200 mg within 3 days of being active prevents most bacteria STDs.

Been on Doxycycline for 2 years. No resistance issues.

It’s considered a minor antibiotic, so for that reason, if you really have something bad there’s being bigger guns to pull out that will not be affected.

Teens have been on 100 mg a day for years to get rid of their acne. So it’s been tested pretty safe.

.

4 Likes
#68

I don’t think 2mg + GFJ will do much more than roughly 7mg equivelent from what I have read here; which isn’t much more than what your taking now. It multiply’s the dose by about 3.5. I was dosing 6mg weekly but I just went to 5mg + GFJ every 10 days based on reading other info. here and will likely go to 6mg + GFJ if the side effects aren’t too bad (glucose mostly). The only side effect I have noticed on either dosing is a few neck pimples and/or small boils. I’m 65 yrs old.

6 Likes