You are correct. I was surprised how little is left considering such a high dose. Even though on average, the pineal gland secretes about 0.1 to 0.8 milligrams (mg) of melatonin per day. The remainder is very small. Unfortunately, I hadn’t done my homework on this. I have taken it in the past in the morning on awakening. It did not cause any drowsiness. John takes a second dose during the night if he wakes up.
“To determine how much melatonin remains in the body after a certain time, given its half-life, we can use the formula for exponential decay. The formula is:
N(t)=N0(12)tT1/2N(t) = N_0 \left(\frac{1}{2}\right)^{\frac{t}{T_{1/2}}}N(t)=N0(21)T1/2t
where:
N(t)N(t)N(t) is the remaining amount of the substance after time ttt,
N0N_0N0 is the initial amount of the substance,
ttt is the elapsed time,
T1/2T_{1/2}T1/2 is the half-life of the substance.
In this case:
N0=500N_0 = 500N0=500 mg (initial amount of melatonin),
T1/2=42.5T_{1/2} = 42.5T1/2=42.5 minutes,
t=24×60t = 24 \times 60t=24×60 minutes (since we need the time in minutes to match the half-life units).
Let’s calculate this step-by-step.
First, convert 24 hours to minutes:
t=24×60=1440 minutest = 24 \times 60 = 1440 \text{ minutes}t=24×60=1440 minutes
Now, use the exponential decay formula:
N(1440)=500(12)144042.5N(1440) = 500 \left(\frac{1}{2}\right)^{\frac{1440}{42.5}}N(1440)=500(21)42.51440
Let’s compute the exponent:
144042.5≈33.882\frac{1440}{42.5} \approx 33.88242.51440≈33.882
Now, calculate the remaining amount:
N(1440)=500(12)33.882N(1440) = 500 \left(\frac{1}{2}\right)^{33.882}N(1440)=500(21)33.882
Let’s solve this.
After 24 hours, the amount of melatonin left in the body would be approximately 3.16×10−83.16 \times 10^{-8}3.16×10−8 mg, which is an extremely small amount, effectively negligible.”
After 12 hours, the amount of melatonin left in the body would be approximately 0.00397 mg, which is still a very small amount"
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Bicep
#16
My daughter ( in her 30’s with 2 little boys) got mucinous ovarian cancer a few years ago and they couldn’t treat with any chemo, so used lots of alternatives instead. There are companys that specialize and work on this. She is currently no evidence of disease. Here is a page for prostate cancer from one of the companies:
It looks like they like metformin, doxycycline (I would take with IV vitamin C), and mebendazole (I’d probably use fenbendazole (my daughter did)). Also use Pectasol, it’s a no brainer.
Good Luck,
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Melatonin in serum Is part metabolised and part absorbed into cells. That absorbed end up iin the mitochondria. I dont know how quickly the mitochondria use it. However, i dont see a reason for frequent daily dosing although it would be an interesting experiment
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No advice, but wanted to commend you on your amazing attitude! Very resilient
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I thought you wanted to bathe your spinal fluid with melatonin.
If that is the case, wouldn’t more frequent dosing be beneficial?
Or, do you think the melatonin remains in the spinal fluid for a longer time?
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My father had prostate cancer and had it removed surgically. It did spread to the bladder and lymph nodes, but they treated it successfully with radiation. It’s now been 3 years after surgery and his PSA is zero and there are no signs of cancer anywhere. He switched to a Pesco-vegetarian diet as he didn’t want growth hormones from meat and animal products feeding the cancer. He was 74 yo at the time of the surgery.
If your cancer has not metastisized, I’d consider surgery and radiation therapy for the cure.
Also, you should check if there are any immunotherapies available. They can do a DNA test to see if you match. If you do, the cancer can usually be cured easily and quickly. IMHO, this is the best option.
The Rapamycin doses for cancer seems to be 5 mg daily based on my research for my father in law who has pancreatic cancer.
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It was Cerebrospinal fluid rather than spinal fluid (the same thing, but to emphasise it goes into the brain). The pineal melatonin is injected into the CSF. I think some of that melatonin (which washes into the brain when the blood pressure goes down as people go to sleep) is metabolised, but as an anti-oxidant rather than the way the liver clears melatonin out of blood.
When you take melatonin into the blood some goes into CSF, some gets metabolised by the liver and some goes into other cells. I don’t think the melatonin that goes into other cells is metabolised per se. I think it ends up in the mitochondria acting as an anti-oxidant. Hence it will have a reducing effect until it is used up. I have no idea of the rate at which it is used up.
There is an argument to take melatonin during the day. I have only done this when drinking, however. I may try it more when not drinking.
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I would not presume to offer clinical advice @Justin but your wait time makes me wonder if it is worth pursuing other options to get a MRI to see if the tumor is isolated. Treatments are very good now, even with advanced PC.
In my view, the USPSTF is unethical and incompetent, They should be disbanded and in the meantime ignored. In the US, they seem to serve only the insurance industry. Their latest stupidity is to recommend against screening for vitamin D levels on the basis – wait for it – that it has no demonstrated benefit in assessing bone integrity. The USPSTF continues to be directly responsible for human suffering.
On PSA screening, switching to the PSA Total+% Free test significantly increases the usefulness of your findings. If they did not run this test on you Justin, you may want to do it on your own. The cost at Life Extension is minimal.
Several years ago, my PSA had crept up to a little above 3.0. Because my father died of metastasized PC at age 86, I began researching interventions to reduce it and switched to the more comprehensive PSA test designed for people who had prostatectomies. I now conduct this test annually. Below is my latest test result from blood drawn this Tuesday.
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For those recommending radiation or contemplating it for themselves, I recommend investigating Proton Beam treatment rather than the ubiquitous ionizing radiation that does so much collateral damage. Unfortunately, there are only a handful of proton treatment centers in the US.
If ionizing radiation was my best practical choice for some reason, I would follow up aggressively to reduce all of my inflammatory markers to basement levels. Even though the PC treatment was “successful,” residual post-radiation vascular inflammation caused a massive blood clot that broke free and killed a good friend of mine. His physicians didn’t even mention the risk to him.
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I don’t give medical advice to others, but here is what i did when I had a high PSA. I had a 4kscore blood test. Developed in Sweden, this is a much better test than standard PSA test and gives an accurate measure of your Gleason score. I also had two tests: a three dimensional Doppler ultrasound and an MRI of the pelvis. These two tests can show where Prostate cancer is exactly (standard biopsies only see one side of the prostate). I also went on a keto diet with very low carbs and high fat though I did eat salads with broccoli sprouts (high in cancer inhibiting sulphurophane). The goal is to reduce insulin, which is the trigger to cancer cells to absorb glucose (even if you stop all carbs your liver will produce glucose by gluconeogenesis).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444768/
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@Uppereast69 I couldn’t tell if your intervention helped or not.
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It is impossible to use ionizing radiation to get rid of tumor cells without extensive collateral damage.
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That’s what I said, “. . . rather than the ubiquitous ionizing radiation that does so much collateral damage.”
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I agree that it is much better, but there is still significant collateral damage with any kind of beam-forming ionizing radiation.
“Compared with traditional radiation, protons have unique properties that allow doctors to better target radiation to the size and shape of the tumor. The proton beam kills the tumor cells and spares more of the surrounding healthy tissue.”
Based on what I could find, there is no clear consensus on the most effective treatment for prostate cancer. There are just too many variables.
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I don’t know what the exact percentages are, they likely vary with context, but proton treatment ionization is relatively de minimis when compared with x-ray treatment. Protons are delivered as particles and therefore can be focused into a much narrower beam (less collateral damage) which can be targeted by depth (minimal collateral damage in transit), stop when they hit the cancer cell (less downstream collateral damage), have a greater chance of killing the cancer cell cf. damaging it as x-ray does, and are molecularly stable (no exchanges). X-rays are delivered as waves in a wide beam. Best case, they damage a large area before, broadly around, and beyond the tumor site. Beyond that, I guess one would have to define what they mean by ‘significant’ but if you were to compare notes with people who have had proton and x-ray treatment in the same area for the same disease, you would not likely to come to the conclusion that both caused significant collateral damage. I think it likely that x-ray treatments are defended in some combination because a proton machine is not available and/or the institution wants to retain the revenue.
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After practicing Calorie restriction for six months and receiving incredible benefits, decided to try Rapamycin. The one thing I noticed immediately within a month was at times an overwhelming sense of well-being and also just a general better mood.
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I’ve listened to your excellent podcasts so I know you are far too clever to think that what I described above is any kind of intervention like Niraparib to deal with prostate cancer. My only point is what I did when I had a high initial PSA score as described by the OP. The result was that I probably didn’t have PC (can’t ever completely rule these things out at my age). I stayed on the diet for about a year. At my next PSA test it was normal (for me). I still eat salads with broccoli sprouts as often as I can.
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KarlT
#33
What did the U/S and MRI show?
As I said, no evident PC was seen in either test.
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Look again at DAV therapy on this site. Rapa + DAV periodically should be a good barrier against cancer.
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