#61

This just came out:

https://www.nature.com/articles/s41586-022-04649-6

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#62

This woman is impressive… Ultramarathon runner at 72.

72-Year-Old Runner Will Not Let This Endurance Race Go

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#63

She is impressive, but I wonder whether she is lengthening her life or shortening it through periodic damage via the marathons.

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#64

I suspect the answer is “shortening” - at least it would be for me. That said, I do think that the bodies of most ultramarathoners is quite different than the average person’s body. The ability to run 100 miles+ is a small sliver of the population. I wonder what their longevity statistics look like.

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#65

No Evidence of an UpperThreshold for Mortality Benefit at High Levels of Cardiorespiratory Fitness (2015)
https://www.jacc.org/doi/epdf/10.1016/j.jacc.2014.11.030

“Although more research is needed on the cardiovascular effects of EEE (extreme endurance exercise), our data caution against any public health message that might dissuade patients from routine vigorous physical activity with the goal of reaching the highest levels of cardiorespiratory fitness”

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#66

a recent news story on this general theme, but largely devoid of any coverage of the advancements in geroscience that are going to make this the new norm (or the norm will be even better):

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#67

The Exercise Boom of the 1970’s resulted in the adoption of habitual exercise in a significant portion of the population. Many of these individuals are defying the cultural norms by remaining physically active and competing at a high level in their later years. The juxtaposition between masters athletes and non-exercisers demonstrate the importance of remaining physically active throughout the lifespan on physiological systems related to healthspan (years of healthy living). This includes ~50% improved maximal aerobic capacity (VO2max) and enhanced skeletal muscle health (size, function, as well as metabolic and communicative properties) compared to non-exercisers at a similar age. By taking a reductionist approach to VO2max and skeletal muscle health, we can gain insight into how aging and habitual exercise affects the aging process. Collectively, this review provides a physiological basis for the elite performances seen in masters athletes, as well as the health implications of lifelong exercise with a focus on VO2max, skeletal muscle metabolic fitness, whole muscle size and function, single muscle fiber physiology, and communicative properties of skeletal muscle. This review has significant public health implications due to the potent health benefits of habitual exercise across the lifespan.

Conclusion

Aging results in numerous physiological detriments that deteriorate overall health and quality of life. Lifelong exercise, as seen in masters athletes, results in ~50% greater VO2max than elderly non-exercisers. This results in lifelong exercisers in their 70’s to have VO2max values similar to the 50th percentile of individuals ~30 y younger and a key factor in these athletes performances and overall healthspan. Their ~50% higher VO2max compared to elderly non-exercisers appears to be mostly due to enhanced stroke volume, while the effect of habitual exercise on HRmax and a-vO2diff remains debated.

Lifelong aerobic exercise in masters athletes also benefits skeletal muscle health as they have significant adaptations to optimize endurance performance. These adaptations include a full preservation of capillarization and oxidative enzyme capacity, a slight shift to slow fiber type distribution and an attenuated accumulation of IMAT. Mode specific adaptations occur within the skeletal muscle based on cycling and running that affect size and function, which likely results in performance benefits in the respective mode. While lifelong aerobic exercise appears beneficial for metabolic health, there remains ambiguity on its effect on whole muscle size and function, including the fast fibers, suggesting the need for additionally explosive training (i. e., strength training, plyometrics, high intensity interval training).

To illustrate the benefits of lifelong aerobic exercise in cardiovascular and skeletal muscle health, [Fig. 7] represents a graphical image of a comprehensive investigation recently completed by the Human Performance Laboratory at Ball State University. As these athletes continue to produce impressive performances, the data collectively suggest that lifelong exercise globally preserves numerous physiological systems associated with aging. Although lifelong exercise does not fully maintain indices of the cardiovascular system and skeletal muscle, these athletes appear to extend their healthspan, decrease their risk of morbidities and mortality, and produce high-level of performances in their advanced age.

Paper: The Aging Athlete: Paradigm of Healthy Aging

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#68
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#69

Well like starting rapamycin 2-years ago on my gut instincts (thought I was one of a few - lol) - glad Matt Kaeberlein directed me to the Rapamycin.news site. I started weight resistance exercising almost 7-years ago… day on - day break, I don’t like the work - hahaha, but cannot deny the overall great feeling day to day and looking good. I can not advocate resistance training enough to those who take rapamycin - it takes both to get the benefits.

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Taken yesterday - 64 is the new 40’s???

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#70

I don’t even know why you keep posting about exercise, should be a closed thread. There’s nothing new about exercise promoting healthspan and lifespan, there a literally thousands of studies already confirming, especially endurance.

A big fat yawn. :wink:

Just kidding of course…maybe you will inspire some to boost their exercise!

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#71

I probably do it for myself to keep myself motivated. I continue to be amazed by the real benefits of exercise, but I do find it hard sometimes to get out and spend the time that I need to doing it.

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#72

Saw this in my twitter feed today - timely to motivate me on my workout program:

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#73
#74

Mick Jagger is great for his age, but his father was well into his 90’s when he died so he might just have a good set of genes.

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#75

I understand that avocados have been shown to be beneficial in the diet of those with cancer.
Avocados are the only fruit (I think) that has a 7-carbon sugar: heptomannulose.
Cancer is unable to utilise this type of sugar. That may explain the benefit of avocados.

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#76

Re PA exercise podcast:

  1. No surprise, PA is a HUGE believer in exercise and healthspan/lifespan expansion. He’s super knowledgeable on the science. He does 100 MET-hrs/week.
  2. They take apart the “J curve” studies on exercise and mortality.
  3. I had never done a V02 max baseline test…I booked one to add to my tracking markers.
  4. PA claims he targets his patients to get to at least 30 ml/min/kg VO2 max.

Exercise is like breathing to me now…cannot do without it. If I miss a day of my exercise routine, I am stressed. Diet-Sleep-Exercise are my 3 foundational pillars.

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The Kipchoge Challenge

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#77

Interesting…glucose starvation cancer axis. Or just a confounder…eating an avocado means you’re perhaps eating less animal protein. I’ve been eating one a day for years.

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#78
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#79

I have been plant-based for 7 years now. Tried low carb before that, but my lipids got too scary. I do take a small amount (600mg) of Bhb daily as a supplement. The abstract implies that eating or injecting it may be useful. Have you seen anything indicating or refuting that eating a bunch of it each day might be as beneficial as a keto diet?

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#80

Blessed are those who find exercise fun.
Blessed are those who can eat an avocado every day.
Blessed are those who can stomach supplements in their coffee.
Blessed are those who enjoy flatulence.
Yada, yadda…
Please feel free to add to the list.

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