Me too! I’ve been with 23nme since 2009! I’ve found it very useful. Recently, I updated the testing since most of what I did long ago needed to be updated. Definitely worth it.
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I think the most useful thing for me was the discovery I have both gene variants for hemochromatosis. Prior to that I was taking massive amounts of vitamin C and B12 which I discovered after testing was driving up my iron levels.
I still recommend Sequencing dot com above other options because of better reviews. They were very fast for me. Nebula and Dante aren’t as reliable overall.
1 Like
Tim
#24
Like others, I gleaned a few nuggets of information from 23andMe, such as no trace of the APOE4 gene. The test also informed that I probably have the genes of a sprinter, which transformed my running style overnight. On the other side of the ledger, they said I don’t have dimples, but I do.
And mine said not likely to be balding. Well, that was inaccurate. 
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If you get genetic analysis, what will you do differently after receiving this information? You should already have the most healthy habits of diet and exercise that you can. Perhaps there are diseases where there are very specific things you can do if you find out you are genetically predisposed to have them?
The 23&Me business model… after everyone has a genetic test who wants to have one, then what? There is no need to get re-tested periodically - your genetics will not change. I’m wondering if they’ve already tested everyone who is interested in being tested.
It looks like Anne Wojcicki is buying the company, as we expected:
23andMe CEO Anne Wojcicki files proposal to take company private as stock craters
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I found the neutrogenomic information from reanalyzing the ancestry consumer genetics to be very useful both through myself and my family. First, if you’re thinking of getting a consumer genetic analysis don’t use 23andMe. And second ignore every thing you get from them and download the raw genome and realize it with promethease or something like that.
Ancestry and 23andme sequence something like 15% of the Genome. Dante and Nebula do the whole thing. I found their reports useless but you can download the rajidome and reanalyze it in Promethiase. Although the FDA has limited Promethease some in order to protect us.
I discovered that I have a homozygous overactive MAOa which means I disolve dopamine as fast as I can make it. People with ths SNP often have poor outcomes due to severe depression.
Fortunately, I had already got started on dopamine precursors because I was involved in an experiment about this.
I have a single APOe4 and that’s good to know about.
My sweetheart and her sisters can’t absorb the standard vitamin B12 used in supplements and I bet is also used in B12 shots. We put them on methylated B12 and it made a big difference.
I recently discovered I have homozygous overactive oxytocin SNPs. I work in the tech field so a significant portion of my male friends are Asperger’s. They keep saying I am too but I’m don’t officially meet diagnostic criteria because I lack social discomfort. That may be because of my homozygous overactive oxytocin SNPs . Oxytocin is the love groovy snuggling mommy nurse you hormone. It can be also involved with the connected loving emotion between adults too.
I also have at least eight overactive cortisol stress hormone homozygous SNPs. That explains why I figured out how to meditate when I was in high school. I need regular meditation not to get stressed out. The recommendation for each of those overactive SNPs was theanine. This is an amino acid that’s in green tea. It’s calming- it brings up GABA which is inhibitory neurotransmitter. It’s why green tea feels different from coffee. Especially good green tea the shade grown. Or you can buy it from Amazon in a bag and take a quarter a teaspoon. There’s interesting research showing that if you couple theanine with caffeine you have better cognitive performance than doing one of them individually.
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Neo
#30
Think you are discussing the sister?
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hamtaro
#31
I actually had the APOE4 (3/4) show up for the Autosomal test, but NOT the full nebula test… who knows why. I’d say, make sure to minimize head injuries, keep blood pressure low, and maintain and healthy blood sugar… and you will likely be fine well into your 80s. My mom is just as sharp as ever at 82, and she’s got the APOE4.
As far as the Oxytocin, I assume you are talking about the OXTR? If so, I do envy you. I was born with the AG variant, and its definitely taking a toll on me.
AnUser
#32
No this is not possible @hamtaro @lawson415, brain traits are highly polygenic, they are hundreds if not thousands of genes with very small effects. You need to look at polygenic risk scores that summate all of these genes and give a percentile score. Nebula does this.
I took a look at this OXTR SNP, and it looks like fake to me, just another candidate gene that probably is false like all the others. It needs to be found via GWAS (genome wide assosciation) study, where the entire genome is scanned without any hypothesis of which gene does what, to find matches.
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hamtaro
#33
Like almost everything else, there are multiple genes at play dealing with social anxiety… .and even Nebula’s attempt to summarize this is still limited.
But the OXTR is a biggie… and the most well-studied common variant of cognitive genes. I’m not suggesting its debilitating… not at all…in fact, the majority of the population has the AA or AG variant. But I’m saying it is a huge factor in social anxiety, and there is a lot of evidence supporting this.
But for those with severe social anxiety… its a far more complicated picture.
AnUser
#34
So tell me then, how did they find this gene? I think it’s a candidate gene. Those do not replicate usually.
Genetics is interesting as an example of a science that overcame a diseased paradigm. For years, basically all candidate gene studies were fake. “How come we can’t find genes for anything?” was never as popular as “where’s my flying car?” as a symbol of how science never advances in the way we optimistically feel like it should. But it could have been.
The Omnigenic Model As Metaphor For Life | Slate Star Codex
Complex traits are usually so many genes. That gene even if true might affect only 0.1% of genetic social anxiety, for example.
Promethease / SNPedia is basically astrology.
Tim
#35
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adssx
#36
Attorney General Bonta Urgently Issues Consumer Alert for 23andMe Customers
Due to the trove of sensitive consumer data 23andMe has amassed, Attorney General Bonta reminds Californians of their right to direct the deletion of their genetic data under the Genetic Information Privacy Act (GIPA) and California Consumer Privacy Act (CCPA).
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AnUser
#38
Ancestry.com works well, where you can upload that DNA for analysis is another question.
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Delete your DNA from 23andMe right now
The genetic information company declared bankruptcy on Sunday, and California’s attorney general has issued a privacy “consumer alert.”
If you’re one of the 15 million people who shared your DNA with 23andMe, it’s time to delete your data.
The genetic information company, best known for its saliva test kits, announced Sunday that it is headed to bankruptcy court to sell its assets. And 23andMe’s financial distress prompted California Attorney General Rob Bonta to issue an unusual privacy “consumer alert” about it Friday.
“I remind Californians to consider invoking their rights and directing 23andMe to delete their data and destroy any samples of genetic material held by the company,” he said in a statement.
Read the full story: Delete your DNA from 23andMe right now (WaPo)
